Method for manufacturing antibacterial medical dressing through using electrostatic spinning

A technology of electrospinning and antibacterial medicine, applied in the field of medical dressings, can solve the problems such as the inability to quickly heal wounds and provide a moist environment, and achieve the effects of good adsorption, large specific surface area and good antibacterial performance.

Inactive Publication Date: 2019-01-04
武汉军嘉特商贸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Historically, flax, honey, animal fat, etc. have been used as wound dressings. These conventional wound dressings are relatively easy to dry, and only provide mechanical protection for the wound, and cannot provide a moist environment for the rapid healing of the wound.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of method adopting electrospinning to prepare antibacterial medical dressing is characterized in that, comprises the following steps:

[0028] (1) dissolving chlorogenic acid in acetic acid to prepare a chlorogenic acid solution with a mass concentration of 5%;

[0029] (2) adding expanded graphite to a mass concentration of 13% N,N-dimethylformamide aqueous solution, then adding nano-titanium oxide, ultrasonic treatment for 1h at a power of 500W, filtering, and drying to obtain nano-titanium oxide / Graphene intercalation composite material; Wherein, the mass ratio of described expanded graphite, nano-titanium oxide is 3:1;

[0030] (3) the nano-titanium oxide / graphene intercalation composite material obtained above is dispersed in absolute ethanol to obtain a dispersion; wherein, the consumption ratio of nano-titanium oxide / graphene intercalation composite material and absolute ethanol is 1g: 40mL;

[0031] (4) Dissolving the gelatin in deionized water at 35-4...

Embodiment 2

[0035] A kind of method adopting electrospinning to prepare antibacterial medical dressing is characterized in that, comprises the following steps:

[0036] (1) Dissolving chlorogenic acid in acetic acid to prepare a chlorogenic acid solution with a mass concentration of 10%;

[0037] (2) adding expanded graphite to a mass concentration of 13% N,N-dimethylformamide aqueous solution, then adding nano-titanium oxide, ultrasonic treatment for 3h at a power of 1000W, filtering, and drying to obtain nano-titanium oxide / Graphene intercalation composite material; Wherein, the mass ratio of described expanded graphite, nano-titanium oxide is 7:1;

[0038] (3) the nano-titanium oxide / graphene intercalation composite material obtained above is dispersed in absolute ethanol to obtain a dispersion; wherein, the consumption ratio of nano-titanium oxide / graphene intercalation composite material and absolute ethanol is 1g: 50mL;

[0039] (4) Dissolving the gelatin in deionized water at 35...

Embodiment 3

[0043] A kind of method adopting electrospinning to prepare antibacterial medical dressing is characterized in that, comprises the following steps:

[0044] (1) Dissolving chlorogenic acid in acetic acid to prepare a chlorogenic acid solution with a mass concentration of 6%;

[0045] (2) adding expanded graphite to the N,N-dimethylformamide aqueous solution with a mass concentration of 13%, then adding nano-titanium oxide, ultrasonic treatment for 1.5h at a power of 600W, filtering, and drying to obtain nano-titanium oxide / Graphene intercalation composite material; Wherein, the mass ratio of described expanded graphite, nano-titanium oxide is 4:1;

[0046] (3) the nano-titanium oxide / graphene intercalation composite material obtained above is dispersed in absolute ethanol to obtain a dispersion; wherein, the consumption ratio of nano-titanium oxide / graphene intercalation composite material and absolute ethanol is 1g: 40mL;

[0047] (4) Dissolving the gelatin in deionized wa...

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Abstract

The invention discloses a method for manufacturing an antibacterial medical dressing through using electrostatic spinning. The method comprises the following steps of firstly, manufacturing a chlorogenic acid solution, and then using a solvent stripping method to manufacture a nano titanium oxide / graphene intercalation composite material, and dispersing in absolute ethyl alcohol to manufacture a dispersion liquid; manufacturing a gelatin water solution, dissolving a polylactic acid fiber in dichloromethane, and then successively adding the gelatin water solution, the dispersion liquid and thechlorogenic acid solution, stirring and mixing uniformly, and then acquiring a spinning solution; and finally, for the acquired spinning solution, using a classical spinning method to prepare a fibermembrane, then filtering, carrying out freeze drying, and then acquiring a medical dressing. In the method, operation is simple, and the acquired medical dressing has good breathability and moisture permeability and has an excellent antibacterial performance, which can effectively promote wound healing.

Description

Technical field: [0001] The invention relates to the field of medical dressings, in particular to a method for preparing antibacterial medical dressings by electrospinning. Background technique: [0002] Wound dressing is a kind of medical material used to cover the surface of the wound and temporarily protect the damaged skin. It can control or avoid wound infection and provide an environment conducive to the rapid healing of the wound. Historically, flax, honey, animal fat, etc. have been used as wound dressings. These conventional wound dressings are relatively easy to dry, and only provide mechanical protection for the wound, and cannot provide a moist environment for the rapid healing of the wound. An ideal wound dressing should have features that accelerate wound healing, prevent infection, and restore skin structure and performance. [0003] Electrospinning technology is an important method of preparing nanofibers that has developed rapidly in recent years. This meth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4382D01F8/14D01F8/02D01F1/10A61F13/02
CPCA61F13/0276D01F1/10D01F8/02D01F8/14D04H1/4382D04H1/728
Inventor 徐亚维
Owner 武汉军嘉特商贸有限公司
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