1/2 water citicoline sodium compound

Abstract

The invention relates to a 1 / 2 water citicoline sodium compound and a preparation method of the 1 / 2 water citicoline sodium compound, wherein each molar of citicoline sodium contains 1 / 2 molar of water. Specifically, the preparation method is as follows: adding a crude product of citicoline sodium, sodium calcium edetate and sodium sulfite into a mixed solution of purified water and acetone, stirring and dissolving; adding activated carbon, stirring, adsorbing, filtering; using an acid to regulate the pH of a filtrate, stirring evenly; slowing adding isopropanol dropwise into the above solution, standing, crystalizing, filtering, washing a filtered material, and drying to obtain the 1 / 2 water citicoline sodium compound. The 1 / 2 water citicoline sodium compound is good in flowability, low in impurity content and hygroscopicity, fast in dissolution and good in stability, and has a broader application prospect.

Description

Technical field

[0001] The invention belongs to the technical field of chemical engineering medicine crystallization, and relates to a 1 / 2 water citicoline sodium compound and a preparation method thereof. Background technique

[0002] Citicoline Sodium is the precursor of phospholipid phosphatidylcholine, and is an essential coenzyme for the synthesis of lecithin. Its molecular formula is C 14 H 25 N 4 NaO 11 P 2 , The molecular weight is 510.31, the CAS number is 33818-15-4, and the structural formula is:

[0003]

[0004] The current methods for preparing citicoline sodium include: (1) Chemical synthesis: using CMP (5'-cytidine acid) and phosphoric acid choline as reactants, p-toluenesulfonyl chloride as a condensing agent, in N-dimethyl Condensation preparation in the presence of formamide, 717 (Cl-) anion exchange column and 711 (Cl-) concentrated column separation liquid alcohol precipitation preparation of citicoline sodium, the disadvantage is that it is difficult to separ...

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