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Gradient 3D (three-dimensional) printing Ti-PDA-BMP-2 bone defect repairing stent and preparation method thereof

A BMP-2, ti-pda-bmp-2 technology, applied in the field of bone tissue repair and reconstruction, can solve the problems of unguaranteed biological safety, high price, allergic reactions, etc., and achieve good bone ingrowth characteristics and Effects of biosafety, improved hydrophilicity and biocompatibility, and improved carrying efficiency

Inactive Publication Date: 2019-01-11
NANJING FIRST HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, biologically active factors have the possibility of immune rejection, pathogen transmission, allergic reaction, potential tumorigenicity, and teratogenicity, and biological safety cannot be guaranteed, and clinical-grade biological factors such as rhBMP-2 and TGF-β often need to be imported, and The price is expensive, and the purchase price per milligram reaches nearly a thousand dollars

Method used

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  • Gradient 3D (three-dimensional) printing Ti-PDA-BMP-2 bone defect repairing stent and preparation method thereof
  • Gradient 3D (three-dimensional) printing Ti-PDA-BMP-2 bone defect repairing stent and preparation method thereof
  • Gradient 3D (three-dimensional) printing Ti-PDA-BMP-2 bone defect repairing stent and preparation method thereof

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Effect test

Embodiment 1

[0032] 1. Preparation of gradient 3D printed Ti scaffolds

[0033] The Ti6Al4V powder is sintered by laser to form a molded fiber bundle, and the 3D printing product is obtained through the splicing structure of different layers and angles of the fiber bundle. Its shape can be 3D printed and personalized according to the shape of the bone defect in the area to be repaired. It can also be manufactured as a scaffold material with a fixed shape by SLM technology, and filled according to the actual bone defect requirements during the operation. The initial pores are 500 microns, increasing 100 microns layer by layer, such as figure 2 shown.

[0034] 2. Preparation of gradient 3D printed Ti-PDA scaffolds

[0035] After the stent structure is constructed by 3D printing, the surface is modified using PDA. The specific steps include:

[0036] 1) preparation concentration is the hydrochloric acid (HCL) solution of 0.5mol / L;

[0037] 2) Weigh 0.61g Tris and add it into 500ml water ...

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Abstract

The invention discloses a gradient 3D (three-dimensional) printing Ti-PDA-BMP-2 bone defect repairing stent and a preparation method thereof. A gradient 3D printing Ti stent being of a gradient pore fiber latticed structure is prepared from Ti6Al4V powder by a 3D printing technique, and biological factors BMP-2 having the bone repairing capability are adhered to the gradient 3D printing Ti stent through polydopamine on the surfaces of fibers, so that the gradient 3D printing Ti-PDA-BMP-2 bone defect repairing stent can be used for the reparative therapy of bone repair. The gradient 3D printingTi-PDA-BMP-2 bone defect repairing stent has the advantages of simple and reliable structure, controllable appearance and microstructure, simple and efficient surface modification, reliable mechanical property, high biological activity and safety, convenient implantation, small trauma and low cost.

Description

technical field [0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a gradient 3D printing Ti-PDA-BMP-2 bone defect repair bracket and a preparation method thereof. Background technique [0002] The repair and reconstruction of bone defects is one of the clinical problems in orthopedics. It is well known that autogenous bone is considered the gold standard for bone grafting, but its source is limited and may lead to complications such as necrosis of the supply site, postoperative chronic pain, allergic reaction, and infection. While allograft bone and xenograft bone are widely used because they come from a wide range of sources and do not require additional surgical operations, but there are also complications such as slow integration and remodeling, immune rejection, and disease transmission, especially reducing the osteoinductive and osteoconductive. [0003] At present, scaffold materials include bioactive calcium phosphate...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06A61L27/54A61L27/56A61F2/28A61F2/30B22F3/105B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/06A61L27/34A61L27/54A61L27/56A61F2/28A61F2/30767A61F2/30771B33Y10/00B33Y70/00B33Y80/00A61F2002/30948A61F2002/3097A61F2002/30968A61F2002/30985A61F2002/3079A61F2310/00976A61F2310/00023A61L2300/252A61L2300/414A61L2430/02B22F10/00B22F10/28C08L79/04Y02P10/25
Inventor 姚庆强王黎明徐燕于一帆
Owner NANJING FIRST HOSPITAL
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