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Gradient 3D printing ti-pda-bmp-2 bone defect repair scaffold and its preparation method

A ti-pda-bmp-2, 3D printing technology, applied in 3D printing, manufacturing tools, additive manufacturing, etc., can solve the problems of unguaranteed biological safety, high price, allergic reactions, etc., and achieve good bone length Introducing characteristics and biological safety, improving hydrophilicity and biocompatibility, and improving carrying efficiency

Inactive Publication Date: 2020-12-08
NANJING FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, biologically active factors have the possibility of immune rejection, pathogen transmission, allergic reaction, potential tumorigenicity, and teratogenicity, and biological safety cannot be guaranteed, and clinical-grade biological factors such as rhBMP-2 and TGF-β often need to be imported, and The price is expensive, and the purchase price per milligram reaches nearly a thousand dollars

Method used

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  • Gradient 3D printing ti-pda-bmp-2 bone defect repair scaffold and its preparation method
  • Gradient 3D printing ti-pda-bmp-2 bone defect repair scaffold and its preparation method
  • Gradient 3D printing ti-pda-bmp-2 bone defect repair scaffold and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Preparation of gradient 3D printing Ti support

[0033] Ti6Al4V powder is sintered by laser to form a shaped fiber bundle, and 3D printing products are obtained through the splicing structure of different layers and angles of the fiber bundle. Its shape can be customized by 3D printing according to the shape of bone defect in different areas to be repaired, or it can be manufactured as scaffold material with fixed shape through SLM technology, and filled according to the requirements of actual bone defect during operation. Its initial pore is 500 microns, and 100 microns are added layer by layer, such as Figure 2 As shown in.

[0034] 2. Prepare gradient 3D printing Ti PDA support

[0035] After the scaffold structure is constructed by 3D printing, the surface is decorated with PDA. The specific steps include:

[0036]1) Prepare hydrochloric acid (HCl) solution with concentration of 0.5mol / l;

[0037] 2) Weigh 0.61g Tris and add it into 500ml water for dissolution. After...

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Abstract

The invention discloses a gradient 3D printing Ti-PDA-BMP-2 bone defect repair bracket and a preparation method thereof. The gradient 3D printing Ti-PDA-BMP-2 bone defect repair bracket of the present invention is prepared from Ti6Al4V powder through 3D printing technology into a gradient 3D printing Ti bracket with a fiber grid structure with gradual pores, and is equipped with polydopamine adhesion on the fiber surface. BMP‑2, a biological factor of bone repair ability, can be used for the repair and treatment of bone defects. The invention has the advantages of simple and reliable structure, controllable shape and microstructure, simple and efficient surface modification, reliable mechanical properties, high biological activity and safety, convenient implantation, less trauma and low cost.

Description

technical field [0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a gradient 3D printing ti-pda-bmp-2 bone defect repair scaffold and a preparation method thereof. Background technology [0002] The repair and reconstruction of bone defect is one of the clinical problems in orthopedics. As we all know, autologous bone is considered to be the gold standard of bone transplantation, but its source is limited and may lead to complications such as necrosis of the supply site, postoperative chronic pain, allergic reaction and infection. Allogeneic bone and xenogeneic bone are widely used because they come from a wide range of sources and do not need additional surgical procedures, but there are also complications such as slow integration and remodeling, immune rejection and disease transmission, especially reducing the bone induction and bone conductivity of the graft. [0003] At present, scaffold materials include bioactive calcium pho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/06A61L27/54A61L27/56A61F2/28A61F2/30B22F3/105B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/06A61L27/34A61L27/54A61L27/56A61F2/28A61F2/30767A61F2/30771B33Y10/00B33Y70/00B33Y80/00A61F2002/30948A61F2002/3097A61F2002/30968A61F2002/30985A61F2002/3079A61F2310/00976A61F2310/00023A61L2300/252A61L2300/414A61L2430/02B22F10/00B22F10/28C08L79/04Y02P10/25
Inventor 姚庆强王黎明徐燕于一帆
Owner NANJING FIRST HOSPITAL
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