A blood purification membrane with anticoagulant performance and its preparation method
A technology for blood purification and performance, applied in the field of surface modification of blood purification membranes, which can solve the problems of harsh reaction conditions, poor anticoagulation effect of blood purification membranes, and limited application range.
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example 1
[0037] A blood purification membrane with anticoagulant properties and a preparation method thereof, adopting the following steps:
[0038] 1) Weigh 1.784g of polyethersulfone (PES) raw material, dissolve it in 10ml of dimethylacetamide (DMAC), at room temperature, and magnetically stir to obtain a light yellow casting solution, let it stand overnight for defoaming, and dissolve it in pure water at 4°C Prepare the membrane according to the liquid-liquid phase conversion method to obtain the PES substrate, soak in double distilled water for 3 days, and set aside;
[0039] 2) Weigh 0.2436g of tris (tris) and dissolve it in double-distilled water, add concentrated hydrochloric acid, adjust the pH to 8.5, and dilute the solution to 200ml to make a pH=8.5 10mmol / L tris solution. PES matrix with smooth surface and uniform thickness was placed in the prepared tris solution, and then 0.4g dopamine was weighed and dissolved in 200ml tris solution, protected from light, and shaken on a ...
example 2
[0043] A blood purification membrane with anticoagulant properties and a preparation method thereof, adopting the following steps:
[0044] 1) Weigh 1.784g of PES raw material, dissolve it in 10ml of DMAC, and stir it with magnetic force at room temperature to obtain a light yellow casting liquid, let it stand overnight to defoam, and make a film in pure water at 4°C according to the liquid-liquid phase conversion method to obtain a PES matrix , after soaking in double distilled water for 3 days, set aside;
[0045] 2) Weigh 0.2436g of tris (tris) and dissolve it in double-distilled water, add concentrated hydrochloric acid, adjust the pH to 8.5, and dilute the solution to 200ml to prepare a pH=8.5 10mmol / L tris solution. Several PES substrates with smooth surface and uniform thickness were placed in the prepared tris solution, then weighed 0.4g of dopamine and dissolved in the tris solution, protected from light, and shaken on a shaker for 8 hours (30°C, 173r / min) to obtain a...
example 3
[0049] A blood purification membrane with anticoagulant properties and a preparation method thereof, adopting the following steps:
[0050] 1) Weigh 1.784g of PES raw material, dissolve it in 10ml of DMAC, and stir it with magnetic force at room temperature to obtain a light yellow casting liquid, let it stand overnight to defoam, and make a film in pure water at 4°C according to the liquid-liquid phase conversion method to obtain a PES matrix , after soaking in double distilled water for 3 days, set aside;
[0051] 2) Weigh 0.2436g of tris (tris) and dissolve it in double-distilled water, add concentrated hydrochloric acid, adjust the pH to 8.5, and dilute the solution to 200ml to prepare a pH=8.5 10mmol / L tris solution. Several PES substrates with smooth surface and uniform thickness were placed in the prepared tris solution, then weighed 0.4g of dopamine and dissolved in the tris solution, protected from light, and shaken on a shaker for 8 hours (30°C, 173r / min) to obtain a...
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