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Fabrication method and application of cobalt-nickel oxide-based nitrofuran antibiotics sensor

A cobalt nickel oxide, nitrofuran technology, applied in chemiluminescence/bioluminescence, analysis by chemical reaction of materials, instruments, etc., can solve the problem of reduced sensitivity, stability and reproducibility of electrochemical sensors, Limiting the application of molecularly imprinted membranes and other issues, to achieve the effects of excellent electron transfer ability, convenient operation, and lower detection costs

Active Publication Date: 2019-01-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electroanalytical chemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • Fabrication method and application of cobalt-nickel oxide-based nitrofuran antibiotics sensor
  • Fabrication method and application of cobalt-nickel oxide-based nitrofuran antibiotics sensor
  • Fabrication method and application of cobalt-nickel oxide-based nitrofuran antibiotics sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of CoNiO-nanoarray

[0031] (1) Use dilute hydrochloric acid, anhydrous ethanol and deionization to clean the disposable disposable electrodes with ultrasonic cleaning to remove the oxide layer and surface impurities of disposable disposable electrodes;

[0032] (2) Weigh 1 mmol Ni(NO 3 ) 2 And Co(NO 3 ) 2 And 3 mmol urea CO(NH 2 ) 2 , Put it into a 50mL beaker, add 30mL deionized water and stir until it is clear, then transfer it to a 50mL PTFE reactor;

[0033] (3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), react at 100°C for 12 hours, then take it out and dry it at 300°C Lower annealing treatment for 3 hours to prepare a cobalt-nickel bimetal oxide nanosheet array precursor electrode;

[0034] (4) Insert the cobalt-nickel bimetal oxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine and ammonium persulfate, and react...

Embodiment 2

[0036] Example 2 Preparation of CoNiO-nanoarray

[0037] (1) Use dilute hydrochloric acid, anhydrous ethanol and deionization to clean the disposable disposable electrodes with ultrasonic cleaning to remove the oxide layer and surface impurities of disposable disposable electrodes;

[0038] (2) Weigh 2 mmol Ni(NO 3 ) 2 And Co(NO 3 ) 2 And 6 mmol urea CO(NH 2 ) 2 , Put it into a 50mL beaker, add 30mL deionized water and stir until it is clear, then transfer it to a 50mL PTFE reactor;

[0039] (3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), react at 110°C for 11 hours, then take it out and dry it at 350°C Lower annealing treatment for 2 hours to prepare a cobalt-nickel bimetal oxide nanosheet array precursor electrode;

[0040] (4) Insert the cobalt-nickel bimetal oxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine and ammonium persulfate, and react...

Embodiment 3

[0042] Example 3 Preparation of CoNiO-nanoarray

[0043] (1) Use dilute hydrochloric acid, anhydrous ethanol and deionization to clean the disposable disposable electrodes with ultrasonic cleaning to remove the oxide layer and surface impurities of disposable disposable electrodes;

[0044] (2) Weigh 3 mmol Ni(NO 3 ) 2 And Co(NO 3 ) 2 And 9 mmol urea CO(NH 2 ) 2 , Put it into a 50mL beaker, add 30mL deionized water and stir until it is clear, then transfer it to a 50mL PTFE reactor;

[0045] (3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), react at 130°C for 9 hours, then take it out and dry it at 400°C Lower annealing treatment for 1 hour to prepare a cobalt-nickel bimetal oxide nanosheet array precursor electrode;

[0046] (4) Insert the cobalt-nickel bimetal oxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine and ammonium persulfate, and react...

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PUM

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Abstract

The invention discloses a fabrication method of a cobalt-nickel oxide-based nitrofuran antibiotics sensor, and belongs to the technical field of novel nanometer functional material and biological sensing analysis. A cobalt-nickel thermometal oxide nanosheet array is fabricated on a disposable throwable electrode, a polydopamine thin film and a molecular imprinting polymer are directly and sequentially fabricated on the cobalt-nickel thermometal oxide nanosheet array by an in-situ growth method according to large specific area, and the molecular imprinting polymer is coated with luminal in an in-situ way and takes nitrofuran antibiotics as a template molecule. After the template molecule is eluted, the original position of the template molecule is changed to holes, and the molecular imprinting molecule of the template molecule is eluted. Therefore, the cobalt-nickel oxide-based nitrofuran antibiotics sensor is fabricated and completed.

Description

Technical field [0001] The invention relates to a preparation method and application of an electrochemiluminescence sensor. It belongs to the field of new nano-functional materials and biosensing analysis technology. Background technique [0002] Nitrofuran antibiotics are a class of 5-nitro-2 substituted furan derivatives, which were once an important class of anti-infective drugs. Such drugs mainly include furazolidone, nitrofurantoin, nitrofurazone, etc., which are mainly used to treat urinary tract infections, intestinal bacterial infections, skin wound infections and as food additives to prevent poultry intestinal infectious diseases. However, due to the genotoxicity and carcinogenic effects of furazolidone, the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) have banned its use in humans and animals in 2005. In addition, nitroheterocyclic compounds have cell mutagenicity and animal carcinogenic toxicity, which has attracted clinical attention. T...

Claims

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Application Information

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IPC IPC(8): G01N27/26G01N27/30G01N27/327G01N21/76
CPCG01N21/76G01N27/26G01N27/30G01N27/3278
Inventor 张勇程荣琦魏琴
Owner UNIV OF JINAN
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