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Application of hirudin for repairing skin red blood filament or hormone face, composition and preparation method

A technology for repairing skin and redness, which is used in skin care preparations, cosmetic preparations, pharmaceutical formulations, etc. to neutralize inflammatory factors, inhibit secretion and diffusion, and improve facial redness and hormones.

Inactive Publication Date: 2019-01-25
重庆雅素生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the field of cosmetics, hirudin has been widely used in freckle removal, acne removal, moisturizing, skin rejuvenation, whitening, skin aging prevention, skin elasticity enhancement, skin cleaning, and dark circle removal; patent CN102178635B uses leech extract, natural hirudin Or recombinant hirudin is used as an active ingredient, and conventional cosmetic raw materials are added to prepare facial cleansing cosmetics, which can clean the skin; patent CN102188360A adopts hirudin or recombinant hirudin as the main active substance to form a composition, which can remove dark circles , but so far, it has not been reported to use hirudin to treat skin redness and hormone face

Method used

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  • Application of hirudin for repairing skin red blood filament or hormone face, composition and preparation method
  • Application of hirudin for repairing skin red blood filament or hormone face, composition and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The gel for repairing skin redness or hormone face, the parts by weight of each component are as follows:

[0027] 1.0 parts of carbo thickener, 0.1 parts of EDTA-2Na, 2.0 parts of glycerin, 4.0 parts of propylene glycol, 2.0 parts of trehalose, 0.1 parts of methylparaben, 2.0 parts of sodium hydroxide, 0.5 parts of recombinant hirudin, rhubarb extract 1 part, 0.1 part of allantoin, appropriate amount of deionized water, wherein recombinant hirudin, rhubarb extract and allantoin account for 2% of the gel mass.

Embodiment 2

[0029] The face cream for repairing skin redness or hormonal face, the parts by weight of each ingredient are as follows:

[0030] 3 parts of isopropyl myristate, 2.5 parts of cetearyl alcohol, 3 parts of jojoba oil, 1 part of mango butter, 1 part of vitamin E, 2.8 parts of pure natural organic olive oil emulsifying wax, glycoside monostearate 1.5 parts of mixture with polyethylene glycol stearate, 0.1 part of propyl p-hydroxybenzoate, 0.5 part of menthol, 5 parts of aloe extract, 4 parts of angelica extract, 2 parts of green tea extract, 1 part of instant pearl powder , 0.3 parts of xanthan gum, 0.2 parts of methyl paraben, 2 parts of BHA, 5 parts of 1,3-butanediol, appropriate amount of TEA, 5 parts of SF-945 silicone oil, 0.2 parts of GPL, appropriate amount of fragrance, 0.3 parts of recombinant hirudin part, 0.8 part of rhubarb extract, 0.07 part of allantoin, appropriate amount of deionized water, wherein recombinant hirudin, rhubarb extract and allantoin account for 1.8...

Embodiment 3

[0032] The face cream for repairing skin redness or hormonal face, the parts by weight of each ingredient are as follows:

[0033] 3 parts of isopropyl myristate, 2.5 parts of cetearyl alcohol, 3 parts of jojoba oil, 1 part of mango butter, 1 part of vitamin E, 2.8 parts of pure natural organic olive oil emulsifying wax, glycoside monostearate 1.5 parts of mixture with polyethylene glycol stearate, 0.1 part of propyl p-hydroxybenzoate, 0.5 part of menthol, 5 parts of aloe extract, 4 parts of angelica extract, 2 parts of green tea extract, 1 part of instant pearl powder , 0.3 parts of xanthan gum, 0.2 parts of methyl p-hydroxybenzoate, 2 parts of BHA, 5 parts of 1,3-butanediol, appropriate amount of TEA, 5 parts of SF-945 silicone oil, 0.2 parts of GPL, appropriate amount of fragrance, the content of the above ingredients is the same as Same as Example 2, 0.3 part of natural hirudin, 0.8 part of rhubarb extract, 0.07 part of allantoin, appropriate amount of deionized water, whe...

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PUM

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Abstract

The invention provides an application of hirudin for repairing skin red blood filament or hormone face, a composition and a preparation method thereof, natural hirudin or recombinant hirudin are takenas main active ingredients, and one or two of rhubarb extract and allantoin are taken as active ingredients together for repairing skin red blood filament or hormone face problems. The invention hasthe beneficial effects that hirudin is the main active ingredient, emodin and allantoin are combined to neutralize inflammatory factors, inhibit the secretion and diffusion of inflammatory factors, rebuild skin barrier, and improve the problems of red blood filament and hormonal face.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to the application, composition and preparation method of hirudin for repairing skin redness or hormone face. Background technique [0002] Hirudin is isolated from the salivary glands on the head of leeches. It is recorded in "Shen Nong's Materia Medica" that it has the effects of breaking blood, removing blood stasis, and stimulating menstruation. Natural hirudin is extracted from the secretion of salivary glands of medical leeches. The single-chain polypeptide composed of 66 amino acid residues has a molecular weight of 7Ku, and its N-terminus contains an active center, which can recognize and bind to the substrate-thrombin basic amino acid enrichment site. The C-terminus is rich in acidic amino acid residues, which can block the recognition site of thrombin and fibrinogen and produce anticoagulant effect. There is also a special sequence composed of Pro-Lys-Pro in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/64A61K8/9789A61Q19/02
CPCA61K8/4946A61K8/64A61Q19/02A61K8/9789
Inventor 周朝强张俊刚
Owner 重庆雅素生物科技有限公司
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