Bionic antimicrobial abdominal wall repair material

A technology for repairing material and abdominal wall, applied in the field of bionic antibacterial abdominal wall repair material, can solve the problems of health economy, social labor loss, prolonging treatment time, etc., and achieves the effect of improving treatment effect, solving technical bottleneck, and being beneficial to tissue regeneration.

Active Publication Date: 2019-01-29
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Abdominal wall defects caused by pollution and infection are very common in the cases of war trauma, traffic injuries, and simultaneous bowel operations. At present, most of these abdominal wall defects are debridement in the first stage, followed by definitive abdominal wall repair with materials in the second stage. It not only prolongs the treatment time, causes long-term pain to the patient, but also causes the loss of health economy and social labor force.

Method used

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  • Bionic antimicrobial abdominal wall repair material
  • Bionic antimicrobial abdominal wall repair material
  • Bionic antimicrobial abdominal wall repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A bionic antibacterial abdominal wall repair material, such as figure 1 As shown, it includes the porcine small intestinal submucosa and the chitosan-elastin fiber network layer covering one side of the porcine small intestinal submucosa.

[0021] The thickness of the above-mentioned chitosan-elastin fiber net layer is 50 microns, the fiber diameter of the nanoscale chitosan-elastin fiber is 100 nanometers, and the nanoscale chitosan-elastin fiber net is prepared by electrospinning And get. Such as figure 2 with image 3 , the above porcine small intestinal submucosa is a 4-layer decellularized porcine small intestinal submucosa material.

[0022] Such as Figure 4 with Figure 5 As shown, the scanning electron micrograph of the prepared bionic antibacterial abdominal wall repair material was obtained by Figure 4 It can be seen that the chitosan-elastin fiber in the bionic antibacterial abdominal wall repair material has a smooth surface, and the fiber diameter ...

Embodiment 2

[0024] A bionic antibacterial abdominal wall repair material, comprising porcine small intestinal submucosa and a chitosan-elastin fiber mesh layer covering one side of the porcine small intestinal submucosa

[0025] The thickness of the nanoscale chitosan-elastin fiber net layer in the present embodiment is 100 microns, and the fiber diameter of the nanoscale chitosan-elastin fiber is 150 nanometers, and the nanoscale chitosan-elastin fiber net Prepared by electrospinning. The porcine small intestinal submucosa in this embodiment is a 4-layer decellularized porcine small intestinal submucosa material.

Embodiment 3

[0027] A bionic and antibacterial abdominal wall repair material comprises pig small intestinal submucosa and a nanoscale chitosan-elastin fiber mesh layer coated on one side of the pig small intestinal submucosa.

[0028] The thickness of the nanoscale chitosan-elastin fiber net layer in the present embodiment is 150 microns, and the fiber diameter of the nanoscale chitosan-elastin fiber is 200 nanometers, and the nanoscale chitosan-elastin fiber net Prepared by electrospinning. The porcine small intestinal submucosa in this embodiment is a 4-layer decellularized porcine small intestinal submucosa material.

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Abstract

The invention discloses a bionic antimicrobial abdominal wall repair material. The bionic antimicrobial abdominal wall repair material includes a pig small intestine submucosa and a chitosan-elastin fiber mesh layer laminating on one side of the pig small intestine submucosa; and the chitosan-elastin fiber mesh layer is an electrostatic spinning nanoscale chitosan- elastin fiber mesh. According tothe bionic antimicrobial abdominal wall repair material, the laminating combination of the chitosan-elastin fiber mesh layer and the pig small intestine submucosa, so that the antimicrobial ability of the prepared abdominal wall repair material is improved effectively; meanwhile, the mechanical strength and degradation performance of the abdominal wall repair material meet the requirement of abdominal wall repair, angiogenesis can further be facilitated, tissue regeneration is facilitated, the existing technical bottleneck of the abdominal wall repair material is solved conveniently, and thetreatment effect of abdominal wall coloboma repair is effectively improved.

Description

technical field [0001] The invention belongs to the technical field of medical consumables, and in particular relates to a bionic antibacterial abdominal wall repair material. Background technique [0002] The development and application of abdominal wall repair materials is an important direction in the current research on hernia and abdominal wall surgery. There are still some problems that need to be solved urgently in the current abdominal wall repair patch. Their major drawback remains low bioactivity, leading to poor vascularization and uneven cellularization of the implant itself, ultimately resulting in lack of integration with surrounding tissues and tissue regeneration. The recent use of acellular matrices in abdominal wall repair represents an effort to develop biomimetic grafts characterized by higher biocompatibility and improved in vivo performance. After implantation, the graft undergoes one of the following fates: (i) neovascularization and new ECM depositi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/36A61L27/20A61L27/22A61L27/54
CPCA61L27/20A61L27/227A61L27/3629A61L27/54A61L2300/252A61L2300/404A61L2300/606C08L89/00C08L5/08
Inventor 李晓明曹广秀牛旭锋樊瑜波
Owner BEIHANG UNIV
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