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A kind of composition and composite calibrator and application thereof

A technology of composition and calibrator, which is applied in the direction of chemical change-inhibiting composition, biological test, material inspection product, etc., and can solve the problems of easy deterioration and poor storage stability

Active Publication Date: 2021-08-10
深圳天辰医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above technical problems, the main purpose of the embodiments of the present invention is to provide a composition as a folic acid protection preparation, aiming to solve the technical problems of existing folic acid calibration products that are easy to deteriorate and have poor storage stability.

Method used

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  • A kind of composition and composite calibrator and application thereof
  • A kind of composition and composite calibrator and application thereof
  • A kind of composition and composite calibrator and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The present embodiment provides a folic acid protection preparation, comprising the following components by weight:

[0055]

[0056] In this embodiment, the synergist is selected as citric acid, the surfactant is selected as Tetronic 1307; the preservative is selected as potassium sorbate; the buffer is selected as phosphate buffer, and its phosphoric acid concentration is 100 mM.

[0057] When in use, mix folic acid and the folic acid protection preparation of the embodiment of the present invention at a mass ratio of 0.005:1 to obtain a composite calibrator, and store it in the dark at 2-8°C.

Embodiment 2

[0059] The present embodiment provides a folic acid protection preparation, comprising the following components by weight:

[0060]

[0061] In this embodiment, the synergist is selected as disodium citrate, the surfactant is selected as fatty alcohol polyoxyethylene ether sodium sulfate; the preservative is selected as sodium benzoate; the buffer is selected as Tris-HCl buffer, wherein the concentration of Tris 150mM.

[0062] When in use, mix folic acid and the folic acid protection preparation of the embodiment of the present invention at a mass ratio of 0.05:1 to obtain a composite calibrator, and store it in the dark at 2-8°C.

Embodiment 3

[0064] The present embodiment provides a folic acid protection preparation, comprising the following components by weight:

[0065]

[0066] In this embodiment, the synergist is selected as citric acid monohydrate, the surfactant is selected as the mixture of fatty alcohol polyoxyethylene ether sodium sulfate and Tetronic 1307; the preservative is selected as biological preservative; the buffer is selected as MES buffer , MES concentration was 70 mM.

[0067] When in use, mix folic acid and the folic acid protection preparation of the embodiment of the present invention at a mass ratio of 0.2:1 to obtain a composite calibrator, and store it in the dark at 2-8°C.

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Abstract

The invention belongs to the technical field of biomolecular in vitro diagnosis, and specifically relates to a composition, a compound calibrator and applications thereof. The composition provided by the invention comprises the following components by weight: 0.5-10 parts of glycerin; 0.01-3 parts of dibutyl hydroxytoluene; 0.01-1 part of synergist; and 0.01-2 parts of surfactant. Glycerol is a stabilizer, which has the function of protective liquid and dehydration protective liquid, and can play a very good protective effect on folic acid antigen; dibutyl hydroxytoluene is an antioxidant, which can react with chain growth free radicals generated in the process of autooxidation, Eliminate free radicals and avoid the oxidation of folic acid; surfactants can replace water and form hydrogen bonds with the hydrophilic groups of folic acid, maintain the stability of the spatial structure of folic acid and avoid aggregation; synergists and antioxidants can be used in combination to increase the antioxidant effect , to better prevent or delay folic acid oxidation. The components work synergistically to increase the stability and shelf life of folic acid.

Description

technical field [0001] The invention belongs to the technical field of biomolecular in vitro diagnosis, and specifically relates to a composition, a compound calibrator and applications thereof. Background technique [0002] Folic acid (folic acid), also known as vitamin B9, is a water-soluble B vitamin. It is an important and essential vitamin for normal cell growth and DNA synthesis in the body. Many foods contain folic acid. After entering the human body, folic acid in food is reduced to physiological functions. The active form of action is tetrahydrofolic acid (THFA), which is a carrier of one-carbon groups in biochemical reactions in vivo. Folic acid carries a carbon group to form N5-methyl THFA, methylene THFA, etc. to participate in the synthesis of purine and thymine, and further synthesize DNA and RNA. Participate in the mutual transformation between glycine and serine, between histidine and glutamic acid, between cysteine ​​and methionine, and participate in the s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N21/76G01N30/72G01N33/53G01N33/82G01N1/28C07D475/04C09K15/08
CPCC07D475/04C09K15/08G01N1/28G01N21/76G01N30/02G01N30/72G01N33/53G01N33/82G01N2001/2893
Inventor 阳云唐灿
Owner 深圳天辰医疗科技有限公司