A kind of binuclear magnesium metal catalyst and its preparation method and application

Abstract

The invention provides a binuclear magnesium metal catalyst as well as its preparation method and application. Catalyst preparation method: under inert gas protection and ice-water bath conditions, first react with N-pyrromethene tert-butylamine ligand with equivalent di-n-butyl magnesium, react the gained solution at room temperature for 2-3 hours, and then add One times the amount of o-methoxybenzaldehyde was added dropwise, and after the reaction was completed, the reaction solution was concentrated in vacuo, extracted with ether, and the extract was filtered and concentrated to separate out colorless transparent crystals. The catalyst has high selectivity and catalytic activity for the cross-coupling Tishchenko reaction, and the preparation method is simple, the raw materials are easily obtained, the reaction conditions are mild, and the catalyst has good industrial application prospects.

Description

technical field

[0001] The invention relates to an organometallic magnesium compound catalyst, in particular to a binuclear magnesium metal catalyst and a preparation method and application thereof. Background technique

[0002] The synthesis of organic esters is an important transformation process in the fields of organic synthesis, pharmaceuticals and food flavor industries. Among them, the Tishchenko reaction has become one of the important reactions for the chemical synthesis of organic esters because it does not generate any by-products and has an atom economy of 100%. However, the Tishchenko reaction has never been a practical method for the synthesis of a large number of ester compounds. Its biggest limitation is that it can only be used to couple two molecules of the same aldehyde, and the resulting ester compounds are of a single type.

[0003] Although, the Stephen J. Connon group has reported the highly selective cross-coupling Tishchenko reaction between differe...

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