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Preparation method for benzhexol molecular imprinting electrochemical sensor

A technology of molecular imprinting and trihexyphenidyl, applied in the direction of material electrochemical variables, etc., can solve the problems of inappropriate matching between functional monomers and template molecules, poor toughness and rigidity of cross-linked films, and low sensitivity, achieving excellent sensitivity, The effect of simple equipment and high sensitivity

Inactive Publication Date: 2019-02-15
GUANGXI UNIV FOR NATITIES
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AI Technical Summary

Problems solved by technology

The current method has low sensitivity and poor drop resistance because the selected functional monomers and template molecules cannot be properly matched, and the toughness and rigidity of the crosslinked film are also poor.

Method used

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  • Preparation method for benzhexol molecular imprinting electrochemical sensor

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Embodiment 1

[0016] 1. Treatment of glassy carbon electrodes

[0017] The glassy carbon electrode was polished with 1.0 μm, 0.3 μm and 0.05 μm alumina powder on a polishing cloth in turn, then placed in nitric acid with a volume ratio of 1:1 for 8 minutes, and then placed in absolute ethanol for 8 minutes , and finally ultrasonically cleaned with pure water.

[0018] 2. Preparation of trihexyphenidyl molecularly imprinted electrochemical sensor

[0019] Prepare 20 mL of a mixed aqueous solution of cobalt sulfate at a concentration of 0.25 mol / L, nickel sulfate at a concentration of 0.25 mol / L and vitamin C at a concentration of 0.5 mol / L with water as a solvent, and prepare a concentration of 0.05 mol with benzyl alcohol as a solvent / L 5 mL of distearyl pentaerythritol diphosphite, and then add 5 mL of distearyl pentaerythritol diphosphite solution dropwise to 20 mL of cobalt sulfate and nickel sulfate prepared above at a rate of 5 drops / second. and vitamin C mixed solution, stirring v...

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Abstract

The invention discloses a preparation method for a benzhexol molecular imprinting electrochemical sensor. The benzhexol is taken as a template molecule, abscisic acid is taken as a functional monomer,azodiisobutyronitrile is taken as initiator, a cobalt-nickel laminated powder body composite material is taken as dopant, 4-ethoxy-4'-phenylbenzonitrile is taken as sensing membrane modifier, oleuropein is taken as cross-linking agent, and therefore, the cobalt-nickel laminated powder body composite material doped benzhexol molecular imprinting electrochemical sensor with high sensitivity and falling resistance is prepared. The analysis method is simple and practical and overcomes the defects that a traditional analysis method is complex and low in sensitivity and equipment is expensive.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a trihexyphenidyl molecularly imprinted electrochemical sensor. Background technique [0002] Trihexyphenyl (Trihexyphenidyl) is clinically used in the treatment of Parkinson's syndrome caused by post-encephalitis or arteriosclerosis. syndrome, dystonia and other diseases. However, excessive use of such drugs can cause side effects such as dry mouth, constipation, urinary retention, mydriasis, blurred vision, brain failure, and liver damage caused by sensitivity to drugs, so they are listed as controlled drugs by most countries in the world. [0003] Methods for the determination of trihexyphenidyl include capillary electrophoresis, high performance liquid chromatography, and gas chromatography. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time-consuming, and lo...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
CPCG01N27/30G01N27/48
Inventor 石展望余会成李浩韦贻春陈其锋
Owner GUANGXI UNIV FOR NATITIES
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