Functionalized wide-width implanted microelectrode array, manufacturing method and application thereof

Abstract

The invention relates to a functionalized wide-width implanted microelectrode array, a manufacturing method and an application thereof. The functionalized wide-width microelectrode array comprises a functional layer, a base layer, a conducting layer and an insulating layer which are successively arranged. The functional layer is a monomolecular layer, a polymer material layer and / or a polymer compound layer, and has the thickness of 1 nm to 1000 micron. The invention also provides the manufacturing method of the functionalized wide-width implanted microelectrode array. By using the functionalized wide-width microelectrode array, through increasing the size of a microelectrode, a microelectrode bit point, a line, a spacing and other correlation parameters can be effectively adjusted so as to reduce a technology complexity during a microelectrode micro-machining process and greatly increase the yield of a high-cost microelectrode array, and the design problem of a high-density microelectrode array is solved; and through a functionalized wide-width design, a microelectrode array folding or curling function can be realized so as to realize minimally invasive implantation and greatly reduce an operation risk.

Description

technical field [0001] The invention relates to a functional wide-width implanted microelectrode array and a preparation method thereof. Background technique [0002] With the continuous acceleration of the pace of life, because people are often in a state of high physical and mental tension, neurological diseases such as retinitis pigmentosa, macular degeneration, depression, and epilepsy are increasing day by day. At the same time, global aging has exacerbated the probability of neurological diseases and become a major social burden. [0003] The rapid development of wearable or implantable electrical nerve stimulation therapy and the appearance of neural prosthesis have brought new hope to the majority of patients. Nerve electrical stimulation therapy is a method of treatment by regulating nerves without destroying nerve tissue, and it can treat or partially restore nerve function. Due to the safety and effectiveness of this method, for some special neurological disease...

AI Technical Summary

Problems solved by technology

Microglia are then activated, and then secrete reactive oxygen species and inflammatory cytokines, some of which are toxic, so their adjacent neurons may be damaged, which seriously affects the performance of nerve electrodes and cannot meet the purpose of long-term implantation

[0006] At present, the work in this field is facing challenges brought about by many scientific and technological problems. Taking the artificial retina as an example, one of the difficulties is that it is difficult to obtain a high-resolution microelectrode array. The main reason is that when the microelectrode array is implanted into the retina, Surgical incisions must be kept below 5 mm. Too large incisions will cause great damage to the normal function of biological tissues. Therefore, the design of the electrode size has strict requirements on the width. For this reason, microelectrodes have long been used in this field. The width of the array is limited to less than 4.5mm. It is difficult to obtain high-resolution microelectrodes in such a narrow area. At the same time, narrow electrodes will also cause difficulties in the design and manufacture of microelectrode sites, lines, and spacing on the electrodes. It greatly increases the complexity of the process in the micro-machining process of the micro-electrode, and the yield rate is very low

In addition, the materials used in the current microelectrode arrays have poor biocompatibility, the body is prone to rejection or immune response, and they do not have anti-inflammatory functions, so it is difficult to meet the effectiveness and safety of long-term implantation.

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