Thermosensitive, conductive and super-tensile collagen-based instant self-healing hydrogel

A stretchable and self-healing technology, applied in the field of collagen-based instant self-healing hydrogels, can solve the problems of poor mechanical properties and formability, poor tensile properties, and no response to temperature changes, and achieve good temperature sensitivity. and electrical conductivity, simple and fast preparation, and the effect of broadening the scope of application

Active Publication Date: 2019-03-12
FUJIAN UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Physical collagen hydrogels with a single force often have poor mechanical properties and formability; collagen hydrogels prepared by chemical cross-linking have strong intermolecular forces, resulting in poor flexibility
[0005] In addition, the common problems of collagen hydrogel prepared by the existing technology are: 1. Poor tensile properties, easy to break when subjected to tension, and cannot achieve large-scale deformation; 2. Easily damaged by external force and unable to repair itself
This brittleness and non-self-healing greatly limit the application of collagen hydrogel materials in biomedicine, electronic skin and other fields.
3. Pure collagen hydrogel has poor electrical conductivity and poor signal transduction effect; 4. Hydrogel has no ability to respond to temperature changes around the skin

Method used

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  • Thermosensitive, conductive and super-tensile collagen-based instant self-healing hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0039] A thermosensitive, conductive and superstretchable collagen-based instant self-healing hydrogel, which comprises the following steps:

[0040] (1) Dissolve guar gum powder in deionized water to prepare a guar gum solution with a concentration of 30 mg / mL, then add N-isopropylacrylamide powder to dissolve it and keep the mass concentration at 0.2% , after dissolving, place the solution in a refrigerator for cold storage;

[0041] (2) Dissolve the freeze-dried collagen sponge in 0.01 mol / L acetic acid solution under ice bath conditions to prepare a collagen solution with a concentration of 30 mg / mL, and then add N-isopropylacrylamide powder to make it After dissolving, keep the mass concentration at 0.2%, and after dissolving, store the solution in a refrigerator;

[0042] (3) Configuration of the guar gum / collagen / graphene oxide composite solution: under ice bath conditions, the 30 mg / L guar gum solution and the 30 mg / L 1 mL of each collagen solution in L was mixed in ...

Embodiment 2

[0045] A thermosensitive, conductive and superstretchable collagen-based instant self-healing hydrogel, which comprises the following steps:

[0046] (1) Dissolve guar gum powder in deionized water to prepare a guar gum solution with a concentration of 40 mg / mL, then add N-isopropylacrylamide powder to dissolve it, and keep the mass concentration at 0.5% , after dissolving, place the solution in a refrigerator for cold storage;

[0047] (2) Dissolve the freeze-dried collagen sponge in 0.01 mol / L acetic acid solution under ice bath conditions to prepare a collagen solution with a concentration of 40 mg / mL, and then add N-isopropylacrylamide powder to make it After dissolving, keep the mass concentration at 0.5%. After dissolving, store the solution in a refrigerator;

[0048] (3) Configuration of the guar gum / collagen / graphene oxide composite solution: under ice bath conditions, the 40 mg / L guar gum solution and the 40 mg / L 1 mL of each collagen solution in L was mixed in equ...

Embodiment 3

[0051] A thermosensitive, conductive and superstretchable collagen-based instant self-healing hydrogel, which comprises the following steps:

[0052] (1) Dissolve guar gum powder in deionized water to prepare a guar gum solution with a concentration of 50 mg / mL, then add N-isopropylacrylamide powder to dissolve it, and keep the mass concentration at 0.8% , after dissolving, place the solution in a refrigerator for cold storage;

[0053] (2) Dissolve the freeze-dried collagen sponge in 0.01 mol / L acetic acid solution under ice bath conditions to prepare a collagen solution with a concentration of 50 mg / mL, and then add N-isopropylacrylamide powder to make it After dissolving, keep the mass concentration at 0.8%. After dissolving, put the solution in the refrigerator for refrigerated storage;

[0054] (3) Configuration of the guar gum / collagen / graphene oxide composite solution: under ice bath conditions, the 50 mg / L guar gum solution and the 50 mg / L Take 1 mL of each L collage...

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Abstract

The invention discloses thermosensitive, conductive and super-tensile collagen-based instant self-healing hydrogel. Guar gum and N-isopropyl acrylamide are led into collagen, and in-situ polymerization is performed to form the hydrogel with a triple structure, so that the hydrogel has a certain strength and thermosensitivity. Oxidized graphene is added, the conductivity of the collagen-based hydrogel can be further improved, the oxidized graphene and a macromolecule network form more reversible physical cross-linking points, and the toughness (tensile property) of the hydrogel is further enhanced. Ion cross-linking action is introduced into collagen and guar gum macromolecules to generate a large quantity of reversible binding sites, and an energy dissipation mechanism is given, so that the hydrogel has good tensile property and self-repairability. A feasible way is provided for preparation of the thermosensitive, conductive and super-tensile collagen-based self-healing hydrogel.

Description

technical field [0001] The invention relates to the technical field of collagen biomaterials, in particular to a heat-sensitive, conductive and superstretchable collagen-based instant self-healing hydrogel. Background technique [0002] Collagen is the main component of the extracellular matrix, accounting for about one-third of the total protein in animals. Hydrogel is a polymer network system, which can rapidly swell and balance in water and maintain its shape and three-dimensional network structure. In recent years, hydrogels, as an important class of biomaterials, have been widely used in the fields of biomedicine and tissue engineering. [0003] Skin is an important sensory organ for human beings. Electronic skin is the main research field of human-computer interaction technology and artificial intelligence, and electronic skin also plays an important role in the field of medical health. In recent years, research on electronic skin is in the ascendant, such as the us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/00C08L89/00C08L33/24C08J3/075C08J3/24C08K3/04
CPCC08J3/075C08J3/246C08J2305/00C08J2389/00C08J2433/24C08K3/042
Inventor 丁翠翠张敏陈礼辉黄六莲史荣会
Owner FUJIAN UNIV OF TECH
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