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Photocatalytic antibacterial hydrogel dressing and preparation method thereof

A hydrogel and photocatalytic technology, applied in medical science, bandages, etc., can solve the problems of bacterial infection, drug resistance during use, and no antibacterial performance, and achieve excellent photocatalytic antibacterial effect, fast Antibacterial, antibacterial effect long-lasting effect

Inactive Publication Date: 2019-03-19
广东省华源康泰生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Conventional hydrogels are composed of natural or synthetic polymers, usually have no antibacterial properties and poor mechanical properties, and cannot solve the problem of bacterial infection well in the process of wound healing
However, some current hydrogel dressings with antibacterial properties usually introduce antibacterial agents or antibacterial ions, such as antibiotics, silver ions, etc. Improper introduction will cause toxicity to the human body, and excessive use may cause negative effects such as drug resistance.

Method used

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  • Photocatalytic antibacterial hydrogel dressing and preparation method thereof
  • Photocatalytic antibacterial hydrogel dressing and preparation method thereof
  • Photocatalytic antibacterial hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Bismuth oxychloride thinning: add bismuth oxychloride (bismuth oxychloride accounts for 0.075wt% of the total amount (concentration of 0.025wt% sodium alginate solution + bismuth oxychloride)), and add it to the seaweed with a concentration of 0.025wt% Mix in the sodium solution, sonicate the mixed solution (power 80W, frequency 45Hz) for 12h, and take the supernatant liquid for later use;

[0037] (2) Mix the sodium alginate solution with a concentration of 1.5wt% and the supernatant in a mass ratio of 1:1, stir evenly, add acrylamide (the amount of acrylamide is 12.5% ​​of the total mass of the mixed solution and acrylamide ), mix uniformly, add 0.06% crosslinking agent N,N-methylenebisacrylamide and 0.09% thermal initiator ammonium persulfate relative to the mass of acrylamide, and mix uniformly to obtain a prepolymerized liquid;

[0038] (3) Pour the pre-polymerization liquid into a mold with a length of 5 cm, a width of 5 cm and a thickness of 2 mm. Put the mold pou...

Embodiment 2

[0046] (1) Thinning bismuth oxychloride: add bismuth oxychloride (bismuth oxychloride accounts for 0.1wt% of the total amount (concentration of 0.05wt% sodium alginate solution + bismuth oxychloride)), and add it to 0.05wt% Mix in the sodium alginate solution, sonicate the mixed solution (power is 100W, frequency is 45Hz) for 10h, and take the supernatant for use;

[0047] (2) Mix the sodium alginate solution with a concentration of 1.75% by weight and the supernatant at a mass ratio of 1:1. After stirring, add acrylamide (the amount of acrylamide is 15% of the total mass of the mixed solution and acrylamide ), mix uniformly, add 0.06% crosslinking agent N,N-methylenebisacrylamide and 0.09% thermal initiator ammonium persulfate relative to the mass of acrylamide, and mix uniformly to obtain a prepolymerized liquid;

[0048] (3) Pour the pre-polymerization liquid into a mold with a length of 5 cm, a width of 5 cm and a thickness of 2 mm. Put the mold poured into the pre-polymerizati...

Embodiment 3

[0054] (1) Thinning bismuth oxychloride: add bismuth oxychloride (bismuth oxychloride accounts for 0.125wt% of the total amount (concentration of 0.1wt% sodium alginate solution + bismuth oxychloride)), and add it to the 0.1wt% Mix in the sodium alginate solution, sonicate the mixed solution (power 150W, frequency 45Hz) for 8h, and take the supernatant for use;

[0055] (2) Mix the sodium alginate solution with a concentration of 2wt% and the supernatant at a mass ratio of 1:1. After stirring, add acrylamide (the amount of acrylamide is 16% of the total mass of the mixed solution and acrylamide) , Mix uniformly, add 0.08% crosslinking agent N,N-methylenebisacrylamide and 0.1% thermal initiator ammonium persulfate relative to the mass of acrylamide, and mix uniformly to obtain prepolymerization liquid;

[0056] (3) Pour the pre-polymerization liquid into a mold with a length of 5 cm, a width of 5 cm and a thickness of 2 mm. Put the mold poured into the pre-polymerization solution in...

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Abstract

The invention belongs to the technical field of medical materials, and discloses a photocatalytic antibacterial hydrogel dressing and a preparation method thereof. The method comprises the following steps: (1) ultrasonically dispersing bismuth oxychloride in a sodium alginate solution to obtain a mixed solution; (2) mixing the mixed solution with acrylamide, a crosslinking agent and an initiator to obtain a prepolymerized solution; and (3) gelatinizing the prepolymerized solution to obtain the photocatalytic antibacterial hydrogel dressing. According to the photocatalytic antibacterial hydrogel dressing and the preparation method thereof, the bismuth oxychloride is ultrasonically stripped in the sodium alginate solution, so that the stripping dispersing effect is good; by combined use of the bismuth oxychloride, sodium alginate and acrylamide, the obtained hydrogel dressing not only has excellent mechanical properties, but also has an excellent photocatalytic antibacterial effect. Themethod disclosed by the invention is simple, high in yield of the hydrogel dressing and stable.

Description

Technical field [0001] The invention belongs to the technical field of medical biological materials, and specifically relates to a photocatalytic antibacterial dressing and a preparation method thereof. Background technique [0002] The skin is an important natural barrier organ that protects internal organs from external environmental interference and prevents dehydration in the body. After injury, it loses its protective mechanism. Wound infection caused by bacteria is one of the most common complications after surgery. If this happens, microorganisms can easily invade and begin to form colonies, which can lead to serious wound infection, hinder the healing process, and even cause life-threatening complications. In addition, severe wound dehydration can interfere with the ideal moist healing environment and delay wound healing. Therefore, efforts are being made to develop new materials for protecting damaged skin from infection and dehydration. Traditional dry dressings such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/075C08F251/00C08F220/56C08F220/58C08F222/38C08F2/44C08K3/22C08L51/02
CPCA61L26/0004A61L26/0014A61L26/0061A61L26/008C08F2/44C08F251/00C08J3/075C08J2351/02C08K3/22C08L51/02C08F220/56C08F222/385C08F220/58
Inventor 宁成云张珂嘉周正难王珍高代聪
Owner 广东省华源康泰生物科技有限责任公司
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