A kind of film-covered drug-loaded airway stent and preparation method thereof

A drug-loading and airway technology, which is applied in the field of medical devices, can solve the problems of difficulty in controlling the thickness of the dip-coated drug-loaded film, drug decomposition, and low drug loading, and achieve good stretchable or compressible effects, short heating time, The effect of improving hydrophilic performance

Active Publication Date: 2021-03-05
GUANGZHOU JOINCARE RESPIRATORY DRUG ENG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, some stent grafts are prepared by fusion bonding, which requires high temperature, which easily leads to the decomposition of the drug, and there are also disadvantages such as difficulty in controlling the thickness of the dip-coated drug-loaded film and low drug loading.

Method used

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  • A kind of film-covered drug-loaded airway stent and preparation method thereof
  • A kind of film-covered drug-loaded airway stent and preparation method thereof
  • A kind of film-covered drug-loaded airway stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A kind of film-covered drug-loaded airway stent comprises a metal mesh stent body (see figure 2 ), the polymer inner membrane arranged on the inner surface of the metal mesh stent body and the drug-loaded film arranged on the outer surface of the metal mesh stent body; the drug-loaded film is composed of the following components: 500g of polyolefin Plastomer (MI=10), 370 g of EVA (VA content 25%, MI=50), 100 g of sodium bicarbonate, 10 g of PEG (molecular weight 500) and 20 g of paclitaxel.

[0052] The preparation method of the covered drug-loaded airway stent comprises the following steps:

[0053] (1) After premixing 500g polyolefin plastomer (MI=10) and 500g EVA (VA content 25%, MI=50) evenly, use a small internal mixer to carry out melt blending at 100°C, and mix for 5 minutes to produce The material was preheated at 100°C for 5 minutes, hot pressed for 1 minute, and cooled for 3 minutes using a hot press molding machine to prepare a polymer inner film;

[0054]...

Embodiment 2

[0059] A film-covered drug-loaded airway stent, comprising a metal mesh stent body, a polymer inner membrane arranged on the inner surface of the metal mesh stent body, and a drug-loaded film arranged on the outer surface of the metal mesh stent body; The drug-loaded film is composed of the following components: 750g polyolefin plastomer (MI=20), 150g EVA (VA content 35%, MI=100), 50g sodium bicarbonate, 20g polyoxyethylene-oxypropylene ether block Copolymer (molecular weight 7000, HLB value 25) and 30 g sirolimus.

[0060] The preparation method of the covered drug-loaded airway stent comprises the following steps:

[0061] (1) After pre-mixing 700g polyolefin plastomer (MI=20) and 300g EVA (VA content 35%, MI=100) evenly, use a small internal mixer to carry out melt blending at 90 ° C, knead for 5 minutes and then produce The material was preheated at 90°C for 5 minutes, hot pressed for 1 minute, and cooled for 3 minutes using a hot press molding machine to prepare a polyme...

Embodiment 3

[0067] A film-covered drug-loaded airway stent, comprising a metal mesh stent body, a polymer inner membrane arranged on the inner surface of the metal mesh stent body, and a drug-loaded film arranged on the outer surface of the metal mesh stent body; The drug-loaded film is composed of the following components: 630g polyolefin plastomer (MI=30), 120g EVA (VA content 45%, MI=50), 100g sodium bicarbonate, 25g PEG (molecular weight is 5000), 25g poly Oxyethylene-oxypropylene ether block copolymer (molecular weight 8000, HLB value 25) and 100 g sirolimus.

[0068] The preparation method of the covered drug-loaded airway stent comprises the following steps:

[0069] (1) After pre-mixing 700g polyolefin plastomer (MI=20) and 300g EVA (VA content 35%, MI=100) evenly, use a small internal mixer to carry out melt blending at 90 ° C, knead for 5 minutes and then produce The material was preheated at 90°C for 5 minutes, hot pressed for 1 minute, and cooled for 3 minutes using a hot pre...

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Abstract

The invention belongs to the technical field of medical devices, and particularly discloses a film-covered drug-carrying airway stent and a preparation method thereof. The stent comprises a metal netty stent body, a high molecular inner film arranged on the inner surface of the metal netty stent body and a drug carrying film arranged on the outer surface of the metal netty stent body, and the drugcarrying film is composed of, by weight, 50-97% of high molecular carrier, 2-10% of pore former, 0.5-10% of hydrophilic modifier and 0.5-10% of drug. An ultrasonic welding mode is adopted to bond thehigh molecular inner film and the drug carrying film onto the metal netty stent body, and sodium hydrogen carbonate is added as the pore former to form pores on the surface of the drug carrying film,so that subsequent drug release speed is increased. The preparation method is simple and short in heating time, thereby being little in heat shock, drug decomposition caused by heating fusion bondingcan be avoided, and good stretchable or compression effect can be maintained.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a film-covered drug-loaded airway stent and a preparation method thereof. The stent has a drug-loading function and can be used to expand a narrowed airway and inhibit the occurrence of airway restenosis. Background technique [0002] Airway stenosis is a life-threatening disease that is congenital or caused by infection, airway tumor, trauma, endobronchial tuberculosis and other diseases. Its clinical manifestations are cough, sputum, dyspnea and even respiratory failure. Tracheal stent is an interventional treatment method used for various benign or malignant airway stenosis, which can relieve the symptoms of tracheal obstruction in patients, play a temporary role in tracheal expansion or support, and provide further treatment (radiotherapy, chemotherapy, etc.) provide opportunity. [0003] According to data released by the National Cancer Center in 2017, the incidenc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/04A61L31/10A61L31/08A61L31/14A61L31/16
CPCA61F2/04A61F2002/046A61F2210/0076A61F2220/0058A61F2240/002A61L31/088A61L31/10A61L31/14A61L31/146A61L31/16A61L2300/416A61L2420/02C08L23/0853
Inventor 阳范文赵珊王晨光梁毓徐蒙蒙欧阳效州雷雨晴李荣荣章喜明田秀梅陈晓明
Owner GUANGZHOU JOINCARE RESPIRATORY DRUG ENG TECH CO LTD
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