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A nano-electrospun membrane with high selectivity for amino acids and its preparation method

A technology for amino acid and selectivity, applied in electrospinning, rayon manufacturing, textile and paper making, etc., can solve problems affecting amino acid adsorption capacity and specific recognition ability, small specific surface area, large diameter, etc., to achieve good selection Effects of adsorption capacity, large specific surface area, and small pore size

Active Publication Date: 2021-04-27
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, molecular imprinting technology is relatively mature for the research of small molecules, but traditionally prepared imprinted materials are mainly molecularly imprinted polymers (MIPs) and molecularly imprinted gels, and the prepared imprinted materials are usually millimeter-scale with relatively The limitation of small surface area and large diameter, which will affect the adsorption capacity and specific recognition ability of imprinted materials for amino acids

Method used

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  • A nano-electrospun membrane with high selectivity for amino acids and its preparation method
  • A nano-electrospun membrane with high selectivity for amino acids and its preparation method
  • A nano-electrospun membrane with high selectivity for amino acids and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Dissolve 10 mg of p-hydroxyphenylpropionic acid as a simulated template in 15 mL of deionized water, then add 2.0 g of polyvinyl alcohol (PVA1799) powder to fully dissolve, and magnetically stir at room temperature for 20 minutes for defoaming treatment. Heating to 95°C and magnetically stirring for 5 h to prepare the spinning solution.

[0034] (2) The spinning solution obtained in (1) was left to defoam for 24 h until there were no bubbles in the solution, and then the solution was injected into a syringe with a diameter of 1 cm and a range of 20 mL. The electrospun nanomembrane was prepared by spinning on the machine for 2 h, wherein the spinning voltage was 15 kV; the spinning distance was 15 cm; the rotating speed of the spinning drum was 500 rps; %; the temperature is 30°C.

[0035] (3) Remove the electrospun nanomembrane obtained in (2), cut into several pieces of 5.0 cm×2.0 cm electrospun nanomembrane with scissors, and then place the cut membrane in a vacuum...

Embodiment 2

[0044] (1) Dissolve 8.0 mg of p-hydroxyphenylpropionic acid as a simulated template in 12 mL of deionized water, then add 2.0 g of polyvinyl alcohol (PVA1799) powder to fully dissolve, and magnetically stir at room temperature for 20 minutes for defoaming treatment. Heating to 95°C and magnetically stirring for 5 h to prepare the spinning solution.

[0045] (2) The spinning solution obtained in (1) was left to defoam for 24 h until there were no bubbles in the solution, and then the solution was injected into a syringe with a diameter of 1 cm and a range of 20 mL. The electrospun nanomembrane was prepared by spinning on the machine for 2 h, wherein the spinning voltage was 15 kV; the spinning distance was 15 cm; the rotating speed of the spinning drum was 500 rps; %; the temperature is 30°C.

[0046] (3) Remove the electrospun nanomembrane obtained in (2), cut into several pieces of 5.0 cm×2.0 cm electrospun nanomembrane with scissors, and then place the cut membrane in a vac...

Embodiment 3

[0049] (1) Dissolve 10 mg of p-hydroxyphenylpropionic acid as a simulated template in 20 mL of deionized water, then add 1.6 g of polyvinyl alcohol (PVA1799) powder to fully dissolve, and magnetically stir at room temperature for 20 min for defoaming treatment. Heating to 95°C and magnetically stirring for 5 h to prepare the spinning solution.

[0050] (2) The spinning solution obtained in (1) was left to defoam for 24 h until there were no bubbles in the solution, and then the solution was injected into a syringe with a diameter of 1 cm and a range of 20 mL. The electrospun nanomembrane was prepared by spinning on the machine for 2 h, wherein the spinning voltage was 15 kV; the spinning distance was 15 cm; the rotating speed of the spinning drum was 500 rps; %; the temperature is 30°C.

[0051] (3) Remove the electrospun nanomembrane obtained in (2), cut into several pieces of 5.0 cm×2.0 cm electrospun nanomembrane with scissors, and then place the cut membrane in a vacuum d...

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Abstract

The invention discloses a novel nano-electrospun membrane with high selectivity to amino acids. The preparation method is as follows: dissolving the simulated template molecules p-hydroxyphenylpropionic acid and polyvinyl alcohol in a certain amount of deionized water, and keeping the temperature at 85-95 ℃ magnetic stirring for 5-7 h to obtain spinning solution, spinning for 1.5-4 h to obtain nano-electrospun membrane, vacuum-drying nano-electrospun membrane for 20-28 h, and then washing with a mixed solution of eluent methanol and acetic acid Stripping molecules. The imprinted nano-electrospinning membrane material prepared by the invention is a nano-scale fiber membrane, has good selective adsorption capacity for tyrosine, and has certain regenerative performance. As a widely used water-soluble polymer, polyvinyl alcohol has the advantages of non-toxic, harmless, oil resistance, and good biocompatibility, and is widely used in many fields such as food, polymer chemical industry, and biomedicine.

Description

technical field [0001] The invention relates to a nano electrospun membrane with high selectivity to amino acids and a preparation method thereof, belonging to the field of functional polymer materials. Background technique [0002] Amino acids are important substances that provide biological nutrition, metabolism and life movement, and are of great significance to human physiological functions. Tyrosine (Tyr) is one of the most important essential amino acids in amino acids, and it is one of the important precursors of biological signal molecules such as adrenal hormone, norepinephrine and dopamine, which are used to regulate mood. If the human body lacks tyrosine, there will be metabolic abnormalities, mental retardation, depression and other diseases, and excessive tyrosine intake will cause changes in sister chromatids, so the separation and detection of tyrosine is also very important a subject. Molecular imprinting technology can prepare polymers with specific recogn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4382D04H1/728D01D5/00D01F1/10D01F6/50
CPCD01D5/003D01D5/0076D01D5/0092D01F1/10D01F6/50D04H1/4382D04H1/728
Inventor 英晓光朱肖梅康安顺
Owner FUZHOU UNIV
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