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Frozen analgesic aerosol and preparation method thereof

An aerosol and analgesic technology, which is applied in the field of frozen analgesic aerosol and its preparation, can solve the problems of high cost, complicated preparation method, and large human body irritation, and achieve lower phase transition temperature and strong skin penetration Action, Diffusion resistance reduction effect

Active Publication Date: 2019-04-05
ZHONGSHAN TIANTU FINE CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the invention has a good analgesic effect, the preparation method is complicated, the cost is high, the anti-inflammatory effect is general, and the wound is easy to cause infection
[0006] In summary, most of the sprays used for analgesic effect in the prior art have complex components and preparation processes, but they cannot provide long-lasting analgesia, and the drug components in the spray are difficult to be absorbed by the human body, and cannot treat damaged epidermal tissue. It has a good repairing effect, and has antibacterial and anti-inflammatory effects, which is more irritating to the human body

Method used

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  • Frozen analgesic aerosol and preparation method thereof
  • Frozen analgesic aerosol and preparation method thereof
  • Frozen analgesic aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 A kind of frozen analgesic aerosol

[0031] The frozen analgesic aerosol is composed of the following components and their weight percentages: pharmaceutical grade dimethyl ether 40.0%, 1-fluoro-3,3,3-difluoropropene 56%, skin penetration enhancer 0.5%, Analgesics 2.0% and Hyaluronic Acid 1.5%.

[0032] The skin penetration enhancer is composed of azone, menthol and chondroitin sulfate in a weight ratio of 4:9:3.

[0033] The analgesic is composed of fumaric tetrahydropalmatine, the extract of Limonium chinensis and glucosamine in a weight ratio of 13:5:12.

[0034] The preparation method of described frozen analgesic aerosol comprises the following steps:

[0035] S1: Add trans-1-fluoro-3,3,3-difluoropropene into trans-1-fluoro-3,3,3-difluoropropene with transdermal enhancer, analgesic and hyaluronic acid, and stir at high speed until the mixture becomes a microemulsion with a particle size of 1 μm solution;

[0036] S2: Pour the micron-level microemul...

Embodiment 2

[0037] Embodiment 2 A kind of frozen analgesic aerosol

[0038]The frozen analgesic aerosol is composed of the following components and their weight percentages: 1,3,3,3-tetrafluoropropene 55.0%, trans-1-fluoro-3,3,3-difluoropropene 39.0%, penetration enhancer 1.2%, analgesic 3.0% and skin tissue repairing agent 1.8%.

[0039] The skin penetration enhancer is composed of azone, menthol and chondroitin sulfate in a weight ratio of 9:7:2.

[0040] The analgesic is composed of fumaric tetrahydropalmatine, the extract of Limonium chinensis and glucosamine in a weight ratio of 16:3:7.

[0041] The skin tissue repairing agent is composed of Eucommia ulmoides extract, allantoin and aloin in a weight ratio of 3:1:1.

[0042] The preparation method of described frozen analgesic aerosol comprises the following steps:

[0043] S1 Add trans-1-fluoro-3,3,3-difluoropropene into trans-1-fluoro-3,3,3-difluoropropene, add transdermal enhancer, analgesic and skin tissue repairing agent, and ...

Embodiment 3

[0045] Embodiment 3 A kind of frozen analgesic aerosol

[0046] The frozen analgesic aerosol is composed of the following components and their weight percentages: 70.0% of liquefied petroleum gas, 22.2% of trans-1-fluoro-3,3,3-difluoropropene, and 1.8% of transdermal accelerator %, analgesics 3.5% and aloin 2.5%.

[0047] The skin penetration enhancer is composed of azone, menthol and chondroitin sulfate in a weight ratio of 13:5:1.

[0048] The analgesic is composed of fumaric tetrahydropalmatine, the extract of Limonium chinensis and glucosamine in a weight ratio of 18:1:4.

[0049] The preparation method of described frozen analgesic aerosol comprises the following steps:

[0050] S1 Add trans-1-fluoro-3,3,3-difluoropropene into trans-1-fluoro-3,3,3-difluoropropene, add transdermal enhancer, analgesic and aloe vera, and stir at high speed until the mixture becomes a microemulsion solution with a particle size of 10 μm ;

[0051] S2: Pour the micron-level microemulsion s...

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Abstract

The invention belongs to the technical field of aerosol for medical preparations, and particularly relates to frozen analgesic aerosol and a preparation method thereof. The frozen analgesic aerosol isprepared from the following components in percentage by weight: 40.0 to 70.0% of propellant, 22.2 to 56.0% of solvent, 0.5 to 1.8% of transdermal enhancer, 2.0 to 3.5% of analgesic and 1.5 to 2.5% ofskin tissue repair agent. The frozen analgesic aerosol provided by the invention has a good analgesic effect, is fast to absorb by a human body, can achieve long-duration analgesia, is convenient tocarry, and is suitable for using when accidents happen in sports, travelling, living or working, skin damage tissues can be repaired, infection can be prevented, swelling and pain can be relieved, andthe frozen analgesic aerosol can be used for treating sports injuries and acute arthritis.

Description

technical field [0001] The invention belongs to the technical field of aerosols for medicinal preparations, in particular to a frozen analgesic aerosol and a preparation method thereof. Background technique [0002] Sports injury refers to the anatomical damage or physiological disorder of human tissues or organs caused by mechanical and physical factors during and after exercise. It is generally divided into two categories: acute injury and chronic injury. Acute injuries include joint sprains, muscle strains, ligament strains, soft tissue contusions, skin abrasions, and joint dislocations, and chronic injuries include arthritis and bursitis. [0003] Among them, acute arthritis refers to the infection of the joint site caused by purulent bacteria, and the clinical manifestations are joint redness, swelling, heat, pain, dysfunction and joint deformity. More than 85% of the common pathogens are Staphylococcus aureus. Most of the infection routes are blood-borne, and a few a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/06A61K36/53A61P17/02A61P19/02A61P29/00A61P31/00A61K31/4375A61K31/7008
CPCA61K9/12A61K31/4375A61K31/7008A61K36/53A61K47/06A61P17/02A61P19/02A61P29/00A61P31/00A61K2300/00
Inventor 温俊帆卢金霞梁高健张为敬雷涛
Owner ZHONGSHAN TIANTU FINE CHEM CO LTD
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