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Preparation of polyester/periodic mesoporous bone-filling composite material with fluorescently-labeled degradation rate, product and application

A fluorescent labeling and degradation rate technology, used in medical science, tissue regeneration, prostheses, etc., can solve problems such as the inability to directly observe the degradation rate and the rate of bone healing, the mismatch of mechanical properties of natural bone, and the uncontrollable degradation time. , to increase the compatibility of the organic-inorganic interface, overcome the decline of material properties, and improve the luminous efficiency and stability.

Active Publication Date: 2019-04-05
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the degradation time of polylactic acid materials as bone repair materials is uncontrollable, the degradation rate of implant materials and the rate of bone healing cannot be directly observed, the mechanical properties do not match natural bone, and the degradation products of implant materials are acidic and easy to cause inflammation, etc. insufficient

Method used

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  • Preparation of polyester/periodic mesoporous bone-filling composite material with fluorescently-labeled degradation rate, product and application
  • Preparation of polyester/periodic mesoporous bone-filling composite material with fluorescently-labeled degradation rate, product and application
  • Preparation of polyester/periodic mesoporous bone-filling composite material with fluorescently-labeled degradation rate, product and application

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Embodiment 1

[0039] A method for preparing a polyester / periodic mesoporous bone-filling composite material whose degradation rate can be fluorescently marked. The biodegradable polylactic acid-based random copolymer is used as the matrix, and the modified rare earth periodic mesoporous fluorescent material is used as the matrix. An enhancer and a fluorescent agent are used to prepare a composite material with self-enhancement effect and degradation rate that can be fluorescently marked, including the following steps:

[0040] 1) Preparation of rare earth periodic mesoporous nanoparticles with fluorescent properties:

[0041] First, carry out amination modification on rare earth complexes: add 20 mL THF solvent into a three-necked flask, then add 2 mmol 0.5366 g N,N'-bis(salicylidene)ethylenediamine (Salen), and wait until it is completely dissolved Add 4 mmol 1.0 g triethoxysilyl isopropyl isocyanate (TEPIC), condense and reflux for 12 h under the protection of nitrogen at 65 °C, and final...

Embodiment 2

[0051] Approximate with embodiment 1 step, comprise the following steps:

[0052] 1) Preparation of rare earth periodic mesoporous nanoparticles with fluorescent properties:

[0053]First, carry out amination modification on rare earth complexes: add 20 mL THF solvent into a three-necked flask, then add 2 mmol 0.5366 g N,N'-bis(salicylidene)ethylenediamine (Salen), and wait until it is completely dissolved Add 4 mmol 1.0 g triethoxysilyl isopropyl isocyanate (TEPIC), condense and reflux for 12 h under the protection of nitrogen at 65 °C, and finally separate and purify the obtained solution by a rotary evaporator to obtain a light yellow viscous The liquid is denoted as Salen-Si; secondly, in situ synthesis of periodic mesoporous graft complex composites: the template agent cetyltrimethylammonium bromide (CTAB) (0.416 g) and NaOH (0.1888 g) were dissolved in de Ionized water (12.72 mL), then a mixed solution of Salen-Si and 1,2-bis(triethoxysilyl)ethane (BTEE) (0.72 mL) was b...

Embodiment 3

[0061] Approximate with embodiment 1 step, comprise the following steps:

[0062] 1) Preparation of rare earth periodic mesoporous nanoparticles with fluorescent properties:

[0063] First, carry out amination modification on the rare earth complex: add 20 ml tetrahydrofuran solvent into a three-necked flask, then add 2 mmol 0.5366 g N,N'-bis(salicylidene)ethylenediamine (Salen), and wait until it is completely dissolved Add 4 mmol 1.0 g triethoxysilyl isopropyl isocyanate (TEPIC), condense and reflux for 12 h under the protection of nitrogen at 65 °C, and finally separate and purify the obtained solution by a rotary evaporator to obtain a light yellow viscous The liquid is denoted as Salen-Si; secondly, in situ synthesis of periodic mesoporous graft complex composites: the template agent cetyltrimethylammonium bromide (CTAB) (0.416 g) and NaOH (0.1888 g) were dissolved in de Ionized water (12.72 mL), then a mixed solution of Salen-Si and 1,2-bis(triethoxysilyl)ethane (BTEE) ...

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Abstract

The invention relates to preparation of polyester / periodic mesoporous bone-filling composite material with a fluorescently-labeled degradation rate, a product and application. The preparation comprises the steps of firstly, synthesizing rare-earth periodic mesoporous nanoparticles with fluorescence performance, then, subjecting the rare-earth periodic mesoporous nanoparticles to chemical modification by taking poly-L-lactic acid with low molecular weight as a modifier, and finally, adding the modified nanoparticles into a polyester matrix by a solution blending method. The invention further provides the product obtained by the method and application of the product in bone restoration as a composite bone filling material. The fluorescent mesoporous material obtained by the method provided by the invention is uniformly dispersed in an organic matrix, mechanical properties of a polyester are improved greatly, and the degradation behavior of the composite bone filling material can be monitored in real time. The preparation process is simple, and the composite bone filling material can serve as a bone filling material of load bearing bone parts with relatively high performance index requirements. The obtained composite material can meet the requirements of clinical application.

Description

technical field [0001] The invention relates to a preparation method of a polyester / periodic mesoporous bone filling composite material whose degradation rate can be fluorescently marked and its product and application, in particular to a biodegradable polylactic acid-based random copolymer as a matrix, with The modified rare earth periodic mesoporous is used as a reinforcing agent and a fluorescent agent, and a composite material with self-reinforcing effect and degradation rate that can be marked by fluorescence is prepared. The invention belongs to the field of biomedical composite materials. Background technique [0002] With the development of medicine and materials science, the clinical application of biodegradable medical materials is becoming more and more common. It is used to replace stainless steel and other metal materials for fixation after fracture reduction, avoiding the risk of secondary surgery and reducing the pain of patients. Polylactic acid and polylac...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/50A61L27/18C08G63/08
CPCA61L27/18A61L27/50A61L27/58A61L2430/02C08G63/08C08L67/04
Inventor 何丹农王杰林于建树王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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