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Efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material and preparation and application methods thereof

A potassium sodium niobate-based implant material technology, which is applied in the field of preparation of bone-promoting implant materials, can solve the problems of secondary injury to patients and inconvenient carrying of external electrical appliances, and achieves good stability, no lead and no pollution. The effect of biocompatibility, high mechanical properties

Active Publication Date: 2019-04-05
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the regulation of stem cell differentiation by electrical stimulation is an important research field of tissue regeneration. A large number of studies have proved that external electrical stimulation can effectively regulate the differentiation direction of stem cells. However, because the external electrical device is inconvenient to carry, inserting the probe is easy to cause secondary damage to the patient.

Method used

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  • Efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material and preparation and application methods thereof
  • Efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material and preparation and application methods thereof

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Effect test

Embodiment 1

[0043] A kind of sodium selenite doping potassium sodium niobate promotes the preparation method of bone piezoelectric ceramic implant, comprising the following steps:

[0044] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 5% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0045](2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, th...

Embodiment 2

[0049] A kind of sodium selenite doping potassium sodium niobate promotes the preparation method of bone piezoelectric ceramic implant, comprising the following steps:

[0050] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 10% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0051] (2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, ...

Embodiment 3

[0055] A kind of sodium selenite doping potassium sodium niobate promotes the preparation method of bone piezoelectric ceramic implant, comprising the following steps:

[0056] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 15% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0057] (2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, ...

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Abstract

The invention belongs to the technical field of osteogenetic implants and discloses an efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material and preparation and application methods thereof. The preparation method of the efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material comprises 1) ball-milling niobium pentoxide, potassium carbonate, sodium carbonate and doping element compounds to obtain ball-milled powder, and calcinating the ball-milled powder to obtain element-doped potassium-sodium niobate-based ceramic powder, whereinthe doping element compounds are compounds of more than one of the elements of selenium, calcium, zinc and iron; 2) uniformly mixing the element doped potassium-sodium niobate-based ceramic powder with bonding agent, and performing pelletizing, shaping, rubber discharging, dense sintering and polarization processing to obtain the efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material. The preparation method of the efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material is simple; the obtained efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material is efficient in osteogenetic performance and stability and good in piezoelectric property. The efficiently osteogenetic potassium-sodium niobate-based piezoelectric implant material is applied to medical osteogenetic materials and / or medical implant materials.

Description

technical field [0001] The invention belongs to the technical field of preparation of bone-promoting implant materials, in particular to a high-efficiency bone-promoting potassium sodium niobate-based piezoelectric implant material and its preparation method and application. Background technique [0002] At present, with the increase of bone tissue damage and loss of function caused by the aging population and accidents, there is an urgent need to develop implant materials that can achieve rapid and effective new bone tissue integration in orthopedic clinics. [0003] Collagen fibers, the basic components of bone tissue, have piezoelectric response properties, and based on this, an electrophysiological microenvironment for bone cells to live in bone tissue is formed. In recent years, the regulation of stem cell differentiation by electrical stimulation is an important research field in tissue regeneration. A large number of studies have proved that external electrical stimul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/495A61L27/10A61L27/50A61L27/04A61L27/54
CPCA61L27/042A61L27/047A61L27/10A61L27/50A61L27/54A61L2300/102A61L2300/412A61L2300/45A61L2300/602A61L2430/02C04B35/495C04B2235/3272C04B2235/3284C04B2235/44C04B2235/442C04B2235/96
Inventor 宁成云姚甜甜陈俊祺肖才榕王珍高张珂嘉胡诗迁
Owner SOUTH CHINA UNIV OF TECH
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