Grain-shaped liquid metal nanoparticles as well as synthetic method and application thereof

A nanoparticle and liquid metal technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and materials for wave energy or particle radiation treatment, and can solve problems such as difficulty in controlling the morphology of liquid metal nanoparticles , to achieve the effect of improving solubility and stability

Active Publication Date: 2019-04-09
JIANGSU INST OF NUCLEAR MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved in the present invention is to overcome the defect that the shape control of liquid metal nanoparticles is difficult in the prior art, thereby providing a preparation method of rice-shaped liquid metal nanoparticles

Method used

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  • Grain-shaped liquid metal nanoparticles as well as synthetic method and application thereof
  • Grain-shaped liquid metal nanoparticles as well as synthetic method and application thereof
  • Grain-shaped liquid metal nanoparticles as well as synthetic method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0080] This embodiment provides a method for synthesizing rice-shaped liquid metal nanoparticles, wherein the liquid metal is gallium-indium eutectic (also known as gallium-indium alloy). The synthesis process of rice-shaped liquid metal nanoparticles is as follows: figure 1 As shown, the specific steps are as follows:

[0081] 1. Synthesis of water-soluble melanin nanoparticles

[0082] Under vigorous stirring, 50 mg of melanin particles were dissolved in 20 mL of 0.1N NaOH to obtain a melanin solution, and 0.1N HCl was dropped into the alkaline pigment solution while ultrasonicating until the pH of the solution was neutralized to 7 to obtain a melanin nanoparticle solution. During the acid-base treatment process, the surface functional groups of the melanin particles are unified, and the melanin particles are changed from particles with large particle size and low water solubility to easily soluble nano-scale particles.

[0083] use The ultrafiltration tube was used to p...

experiment example 1

[0188] In this experimental example, the liquid metal nanoparticles in Example 1 and Comparative Examples 1-8 are characterized by ultraviolet-visible absorption spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential, in order to monitor different ultrasonic time Kinetics of the formation of liquid metal nanoparticles. The monitoring results are as follows:

[0189] Figure 9 Show the transmission electron microscope (TEM) image of liquid metal nanoparticles in Example 1 and Comparative Examples 1-6, scale bar, 100nm; Figure 10 Transmission electron microscope (TEM) images of liquid metal nanoparticles in Comparative Examples 7-8 are shown. Depend on Figure 9 and Figure 10 It can be seen that when the ultrasonic treatment time is less than 15 minutes, the shape of the liquid metal nanoparticles is spherical, and when the ultrasonic treatment time reaches 15 minutes, the liquid metal nanoparticles grow into a rice shape. ...

experiment example 2

[0194] In this experimental example, the liquid metal nanoparticles in Example 1 and Comparative Examples 9-14 were characterized by transmission electron microscope (TEM), daylight image observation of liquid metal nanoparticle suspension, dynamic light scattering (DLS) and zeta potential. To detect the concentration dependence of liquid metal nanoparticles on melanin nanoparticles. The test results are as follows:

[0195] Figure 14 Transmission electron microscope (TEM) images showing the liquid metal nanoparticles of Example 1 and Comparative Examples 12-14, scale bar, 250 nm. Depend on Figure 14 It can be seen that when the concentration of melanin nanoparticles is 0.25mg / mL, rice-shaped liquid metal nanoparticles can be obtained, and when a higher concentration of melanin nanoparticles is fed, the liquid metal nanoparticles grow into spherical shapes.

[0196] Figure 15 Daylight images of the liquid metal nanoparticle suspensions of Example 1 and Comparative Examp...

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Abstract

The invention discloses a synthetic method of grain-shaped liquid metal nanoparticles. The liquid metal is gallium and indium eutectic. In the synthetic method, melanin nanoparticles stabilize the gallium and indium eutectic, and the grain-shaped liquid metal nanoparticles are obtained through controlling the ultrasonic time equal to or greater than 15 minutes and the concentration of the melaninnanoparticles equal to or less than 0.25mg / mL. The grain-shaped liquid metal nanoparticles are high in photothermal conversion efficiency and light & heat stability and are better photothermal therapymaterials. The invention further discloses the grain-shaped liquid metal nanoparticles; the liquid metal nanoparticles are gallium and indium eutectic nanoparticles; the surfaces of the gallium and indium eutectic nanoparticles are chelate with the melanin nanoparticles; and the aspect ratio of the liquid metal nanoparticles is 2:1-3:1. The grain-shaped liquid metal nanoparticles are high in photothermal conversion efficiency, light & heat stability and biocompatibility and excellent in tumour ablation effect, and can be used as the photothermal therapy materials for photothermal therapy of the tumor.

Description

technical field [0001] The invention relates to the technical field of liquid metal, in particular to a rice-shaped liquid metal nanoparticle and a synthesis method and application thereof. Background technique [0002] Nanomaterials have attracted widespread attention due to their special properties such as small size effect, surface effect, quantum size effect and macroscopic quantum tunneling effect. The properties of nanoparticles are closely related to their composition and morphology. Metal nanoparticles or alloy nanoparticles with specific shapes are widely used in new energy, photoelectric information storage, catalytic chemistry due to their special optical, electrical, thermal, mechanical, magnetic and catalytic properties. , Imaging, sensing and biomedical fields have broad application prospects. [0003] The preparation methods of metal or alloy nanoparticles mainly include two types: top-down method (top-down) and bottom-up method (bottom-up). The top-down met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61K47/54A61P35/00
CPCA61K9/145A61K41/0052A61P35/00
Inventor 严骏杰杨敏王辛宇潘栋辉徐宇平杨润琳王立振赵富宽张波
Owner JIANGSU INST OF NUCLEAR MEDICINE
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