Pellet containing lycopene and preparation method of pellet

A technology of lycopene and pellets, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, microcapsules, etc., can solve the problems of poor stability and low water solubility of lycopene, and achieve particle size reduction and preparation method Ease of operation and the effect of increasing the contact surface area

Inactive Publication Date: 2019-04-26
安徽瑞达健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thereby solving problems such as low water solubility and poor stability in lycopene in the art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take by weighing 100g povidone K30, add in 400ml dichloromethane, stir until fully dissolved, weigh 20g lycopene (produced by Shaanxi Senfu Natural Products Co., Ltd.), add to the above solution and stir until completely dissolved; 220g microcrystalline cellulose, 200g cornstarch, after using the povidone K30-70% ethanol solution wetting of 150ml 10%, add in the centrifugal granulation coating machine (Chongqing Yingge granulation coating technology Co., Ltd.), adopt Commonly used parameters are mixed and sprayed into pellets at a rate of 48g / min, atomization pressure of 2.0psi, and material temperature of 62°C to obtain the final pellets containing lycopene.

Embodiment 2

[0033] Take by weighing 100g povidone K30, join in 380ml ethyl acetate, stir until dissolving completely, take by weighing 25g lycopene (produced by Shaanxi Senfu Natural Products Co., Ltd.), join in the above solution and stir until fully dissolved; 220g microcrystalline cellulose, 200g cornstarch, after using the povidone K30-70% ethanol solution wetting of 150ml 10%, add in the centrifugal granulation coating machine (Chongqing Yingge granulation coating technology Co., Ltd.), adopt Commonly used parameters are mixed and sprayed into pellets. The spray rate is 49g / min, the atomization pressure is 2.2psi, and the material temperature is 64°C to obtain the final pellets containing lycopene.

Embodiment 3

[0035] Take by weighing 100g povidone K30, join in 420ml methylene chloride, stir until fully dissolved, weigh 35g lycopene (produced by Shaanxi Senfu Natural Products Co., Ltd.), add to the above solution and stir until completely dissolved; 220g microcrystalline cellulose, 200g cornstarch, after using the povidone K30-70% ethanol solution wetting of 150ml 10%, add in the centrifugal granulation coating machine (Chongqing Yingge granulation coating technology Co., Ltd.), adopt The common parameters are mixed and then sprayed into pellets. The spray rate is 50g / min, the atomization pressure is 2.5psi, and the material temperature is 65°C to obtain the final pellets containing lycopene. The prepared pellets are compressed into tablets according to the conventional method.

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PUM

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Abstract

The invention discloses a pellet containing lycopene and a preparation method of the pellet and particularly relates to the field of pharmaceutic preparations. The preparation method comprises the following operation steps: step one, dissolving the lycopene as an active component into a water soluble carrier-organic solvent solution; step two, spraying and pelleting by a centrifugal granulation coating machine and preparing the lycopene and partial pharmaceutic adjuvants into pellets. The active component is dissolved into an organic solvent and then spraying and pelleting are performed, so that the particle size of the lycopene is effectively reduced, water solubility is improved, the bioavailability is improved, and residual organic solvents are greatly reduced. The pellet disclosed by the invention can be suitable for application and industrial production of oral dosage forms such as tablets, granules, enteric capsules, enteric coated tablets, enteric coated granules and the like.

Description

Technical field: [0001] The invention relates to the related technical field of pharmaceutical preparations, in particular to a pellet containing lycopene and a preparation method thereof. Background technique: [0002] As a carotenoid, lycopene is a natural pigment present in food materials such as tomatoes. It is a straight-chain polyunsaturated olefin composed of 11 conjugated double bonds and 2 non-conjugated double bonds. The molecular formula is C 40 h 56 , molecular weight 536.85. It is widely found in plants, and its content is more in red fruits such as ripe tomatoes, watermelons, carrots, and red grapefruits. More lycopene. Lycopene has a strong ability to scavenge free radicals and resist oxidation. Its ability to quench singlet oxygen and scavenge free radicals is 100 times that of vitamin E, a commonly used antioxidant, and more than 2 times that of β-carotene. Eating foods rich in lycopene can effectively reduce the risk of various chronic non-communicable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/01A61K47/38A61K47/36A61P39/06A61P35/00A61P9/00
CPCA61K9/5036A61K9/5042A61K31/01A61P9/00A61P35/00A61P39/06
Inventor 顾大业郭岩刘丹吴疆王保如
Owner 安徽瑞达健康产业有限公司
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