Preparation method of methylprednisolone hemisuccinate impurity

A technology of methylprednisolone succinate and succinate, which is applied in the field of chemical synthesis to achieve the effects of improving quality standards, clear synthesis paths and high product purity
CN109678919AActive Publication Date: 2019-04-26CHONGQING HUABANGSHENGKAI PHARM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING HUABANGSHENGKAI PHARM
Publication Date
2019-04-26

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Abstract

The invention belongs to the technical field of chemical synthesis, and relates to a preparation method of a methylprednisolone hemisuccinate impurity, in particular to a preparation method of 11 beta, 17 alpha, 21-trihydroxy-6 beta-methylpregna-1,4-diene-3,20-diketone-21-succinic acid ester. According to the method, 11 beta, 17 alpha, 21- trihydroxy-6 beta-methylenepregna-4-alkene-3, 20-diketoneis taken as a raw material, and is subjected to a series of reduction reaction, esterification reaction, oxidation reaction and hydrolysis reaction, so that the 11 beta, 17 alpha, 21-trihydroxy-6 beta-methylpregna-1,4-diene-3,20-diketone-21-succinic acid ester is obtained. The invention firstly discloses the preparation method of the impurity, and has the advantages of clear synthetic route, simple operation, relatively high purity of a prepared product and the like.
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Description

technical field

[0001] The invention belongs to the technical field of chemical synthesis, and specifically relates to a preparation method of 11β, 17α, 21-trihydroxy-6β-methylpregna-1,4-diene-3,20-diketone-21-succinate. Background technique

[0002] 11β, 17α, 21-trihydroxy-6β-methylpregna-1,4-diene-3,20-dione-21-succinate, is an impurity of methylprednisolone succinate, according to European Pharmacopoeia Record, the structural formula is as follows:

[0003]

[0004] Methylprednisolone succinate has the following structural formula:

[0005]

[0006] Methylprednisolone succinate is a synthetic glucocorticoid. Glucocorticoids diffuse through the cell membrane and bind to specific receptors in the cytoplasm. It has anti-inflammatory, immune and anti-allergic activities, used for symptomatic treatment of rheumatic diseases, collagen diseases, skin diseases, allergic symptoms, eye diseases, gastrointestinal diseases, respiratory diseases, edema, etc., as an immunosupp...

Claims

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