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A method for improving compound stability of potassium methoxysalicylate and tranexamic acid

A technology of potassium methoxysalicylate and tranexamic acid, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as poor stability and discoloration of whitening products, and achieve the best user experience and long-term stability , the effect of preventing photochemical reactions

Active Publication Date: 2021-11-16
SHANGHAI JAKA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the poor stability of the compounding of potassium methoxysalicylate and tranexamic acid, which leads to discoloration of whitening products, the present invention provides a method for improving the compounding stability of potassium methoxysalicylate and tranexamic acid, effectively improving It ensures the stability of the appearance and color of whitening products, and can make the dosage of potassium methoxysalicylate and tranexamic acid reach a relatively high dosage, ensuring the whitening effect of whitening products

Method used

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  • A method for improving compound stability of potassium methoxysalicylate and tranexamic acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weigh the raw materials according to the following proportions for later use:

[0035] Phase A: 0.1g disodium EDTA, 0.2g xanthan gum, 1g glycerin, 2g butanediol, 1g plant extract composition and 80g water;

[0036] Phase B: PEG-100 stearate 1g, cetearyl alcohol 0.5g, glyceryl stearate 0.5g, C14-22 alcohol 1g, C12-20 alkyl glucoside 1g, squalane 1g, palmitic acid Ethylhexyl ester 2g and polydimethylsiloxane 3g;

[0037] Phase C: 0.04g sodium hydroxide, 0.1g preservative, 0.1g potassium methoxysalicylate, 0.1g tranexamic acid, 0.01g essence; 0.1g photoprotectant; 0.08g pH regulator; pH control of phase C at 6.5;

[0038] Among them, the photoprotectant components are: benzophenone-4 0.01g, dibutyl adipate 0.01g, diethylamino hydroxybenzoyl hexyl benzoate 0.01g, ethylhexyl methoxycinnamate 0.01 g, laureth-7 citrate 0.01g, polyglyceryl-2 dipolyhydroxystearate 0.01g, ethylhexyl triazone 0.01g, bis-ethylhexyloxyphenol methoxyphenyl triazone Oxyzine 0.01g, lauryl gluco...

Embodiment 2

[0046] (1) Weigh the raw materials according to the following proportions for later use:

[0047]Phase A: 0.3g disodium EDTA, 1g xanthan gum, 5g glycerin, 4g butanediol, 8g plant extract composition and 60g water;

[0048] Phase B: PEG-100 stearate 3g, cetearyl alcohol 1.5g, glyceryl stearate 1g, C14-22 alcohol 5g, C12-20 alkyl glucoside 5g, squalane 5g, ethyl palmitate Hexyl ester 7g and polydimethylsiloxane 0.5g;

[0049] Phase C: 0.25g sodium hydroxide, 0.2g preservative, 1g potassium methoxysalicylate, 3g tranexamic acid, 0.2g essence; 10g photoprotectant; 15.12g pH regulator; the pH value of phase C is controlled at 4.5 ;

[0050] Among them, the photoprotectant components are: benzophenone-4 1g, dibutyl adipate 1g, diethylamino hydroxybenzoyl hexyl benzoate 1g, ethylhexyl methoxycinnamate 1g, lauryl alcohol Polyether-7 Citrate 1g, Polyglyceryl-2 Dipolyhydroxystearate 1g, Ethylhexyl Triazone 1g, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 1g, Lauryl Glucoside 1g, 1...

Embodiment 3

[0058] (1) Weigh the raw materials according to the following proportions for later use:

[0059] Phase A: 0.2g disodium EDTA, 0.8g xanthan gum, 3g glycerin, 3g butanediol, 5g plant extract composition and 70g water;

[0060] Phase B: PEG-100 stearate 2g, cetearyl alcohol 1.0g, glyceryl stearate 0.8g, C14-22 alcohol 3g, C12-20 alkyl glucoside 3g, squalane 4g, palmitic acid Ethylhexyl ester 5g and polydimethylsiloxane 2.0g;

[0061] Phase C: 0.10g sodium hydroxide, 0.15g preservative, 0.15g potassium methoxysalicylate, 0.2g tranexamic acid, 0.1g essence; 2.3g photoprotectant; 10.065g pH regulator; pH value of phase C Control at 5.0;

[0062] Among them, the photoprotectant components are: benzophenone-4 0.05g, dibutyl adipate 0.05g, diethylamine hydroxybenzoyl hexyl benzoate 0.08g, ethylhexyl methoxycinnamate 0.02 g, Laureth-7 Citrate 0.03g, Polyglyceryl-2 Dipolyhydroxystearate 0.5g, Ethylhexyl Triazone 0.5g, Bis-Ethylhexyloxyphenol Methoxyphenyl Tris Oxyzine 0.75g, Lauryl ...

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Abstract

The invention relates to the technical field of cosmetics, in particular to a method for improving the compound stability of potassium methoxysalicylate and tranexamic acid, adding a photoprotectant to the compound system of potassium methoxysalicylate and tranexamic acid, and The pH value of the adjustment system is controlled at 4.5-6.5. The invention solves the problem of discoloration caused by the combination of potassium methoxysalicylate and tranexamic acid in a short period of time by adding a photoprotectant and adjusting the pH value of the product, and effectively protects the stability of the appearance and color of the product , and can achieve a relatively high dosage of potassium methoxysalicylate and tranexamic acid. The appearance and color stability of the prepared product have been significantly improved, and there is no obvious color change for a long period of time, which proves to be effective in preventing and delaying the photochemical reaction caused by the interaction between potassium methoxysalicylate and tranexamic acid. The reaction is effective, which can make the product more stable for a longer period of time, so that consumers can get a better use experience.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a method for improving the compound stability of potassium methoxysalicylate and tranexamic acid. Background technique [0002] The cosmetics market is becoming more and more mature, and women who love beauty pay more and more attention to their own image. As an important cosmetic category, whitening is favored by the majority of women and occupies a considerable share in the market. Various whitening ingredients added to whitening products are also changing with each passing day. Potassium methoxysalicylate (4MSK), as a relatively new whitening ingredient, has the effect of inhibiting melanin production and has excellent defense against pigmentation caused by ultraviolet rays Effect, its whitening effect has been recognized by consumers. However, the effect of a single whitening raw material is often not as remarkable as the combined use of two or more whitening raw materials...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/368A61K8/44A61K8/35A61K8/37A61K8/86A61K8/85A61K8/49A61K8/60A61K8/41A61K8/365A61K8/20A61K8/19A61Q19/00A61Q19/02
Inventor 刘春君谢红
Owner SHANGHAI JAKA BIOTECH CO LTD