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A kind of medicine for tumor treatment and its preparation method and application

A tumor treatment and drug technology, applied in the field of tumor treatment drugs and its preparation, can solve the problems of difficult to reach deep lesion areas, low gas controllable release efficiency, etc., achieve good acid responsiveness, good biological safety, and prolong survival the effect of time

Active Publication Date: 2021-06-22
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, hydrogen administration methods mainly include inhaling hydrogen, drinking hydrogen water, injecting hydrogen saline, etc. These methods are either difficult to reach deep lesion areas, or the controllable release efficiency of gas is not high. Controlled release is the main challenge facing hydrogen therapy today

Method used

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  • A kind of medicine for tumor treatment and its preparation method and application
  • A kind of medicine for tumor treatment and its preparation method and application
  • A kind of medicine for tumor treatment and its preparation method and application

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Experimental program
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Embodiment 1

[0036] Preparation of materials: firstly H 2 O (120ml), MgB 2 (90mg), PEG (4000) (450mg) were mixed uniformly in the container, placed on ice bath, and added H 2 o 2 (9ml) and HAc (180ul), and then use an ultrasonic breaker to break the glass. The parameters of the ultrasonic breaker are set as follows: the horn is 6, (intermittent time) 2.2s / (working time) 6.6s, and a total of 60 minutes of ultrasonication. After the ultrasonic crushing is completed, immediately divide into 50ml centrifuge tubes for centrifugation (12500r / s, 25min), and wash the obtained precipitate twice with water (12500r / s, 25min) and with absolute ethanol twice (12500r / s, 10min). . The final precipitate was vacuum-dried for 5 h to obtain novel two-dimensional magnesium boride nanosheets MBNs.

[0037] figure 1 It is the transmission electron microscope (TEM) and scanning electron microscope (SEM) images of the material, indicating that the MBNs material prepared above is a network structure of two-di...

Embodiment 2

[0040] To detect the toxicity of hydrogen gas combined with chemotherapy drug DOX on cancer cells and normal cells and the effect on ATP production. The cells selected were gastric cancer cells (BGC-823) and four normal cells (H9C2, LO2, mMSC, HEK-293 cells). And each cell was divided into air group, air+DOX (1 μg / mL, 0.5 μg / mL, 0.25 μg / mL, 0.125 μg / mL), hydrogen group, hydrogen+DOX (1 μg / mL, 0.5 μg / mL, 0.25μg / mL, 0.125μg / mL) groups to detect the attenuation and synergistic effect of hydrogen on chemotherapy drugs, in which hydrogen group, hydrogen + DOX (1μg / mL, 0.5μg / mL, 0.25μg / mL, 0.125μg / mL ) group, cultivated in a special hydrogen incubator containing 60%. Image 6 Demonstrated the attenuation and synergistic effect of hydrogen on chemotherapy drugs at the cellular level, the results showed that the DOX concentration (1 μg / mL, 0.5 μg / mL, 0.25 μg / mL, 0.125 μg / mL) damages cancer cells with The increase of DOX concentration increases, and it also has the same damage pattern...

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Abstract

A drug for tumor treatment and its preparation method and application. The present invention relates to a drug, aiming at the problems existing in the targeted delivery and controllable release of hydrogen. One of the purposes of the present invention is to provide a metal boron The compound is used in the application of the tumor treatment and the medicine for the tumor treatment, and the medicine includes the nanometer metal boride and the surface-modified protective agent. The novel two-dimensional nanosheet material prepared by the present invention has the following advantages: 1) MBNs two-dimensional nanomaterials obtained in the present invention have good biological safety; 2) MBNs two-dimensional nanomaterials obtained in the present invention have good acid response 3) It can be combined with radiotherapy and chemotherapy drugs to treat gastric cancer. 4) It does not affect normal cells and tissues; 5) The hydrogen gas released by MBNs@PVP in the acidic environment of the stomach has the effect of attenuating and increasing the efficiency of radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to a medicament, especially a medicament for treating tumors, a preparation method and application thereof. Background technique [0002] Chemoradiotherapy is the main method for clinical treatment of cancer, especially advanced cancer, and is an effective systemic treatment. However, the traditional chemoradiotherapy drugs and administration methods have the disadvantages of non-specific recognition of chemoradiotherapy drugs, which can easily damage normal cells and tissues, and even cause systemic poisoning. Moreover, the efficiency of drug uptake by tumor cells is low, and repeated administration can easily cause tumors. Cells develop drug resistance and other shortcomings. [0003] As an emerging tumor treatment technology, gas therapy mainly utilizes therapeutic gas (hydrogen H 2 , Nitric Oxide NO, Carbon Monoxide CO, Hydrogen Sulfide H 2 S, etc.) to replace or assist traditional radiotherapy and chemotherapy, and reduce ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/22A61K33/32A61K33/26A61K33/38A61K33/24A61P35/00B82Y5/00A61K31/704A61K31/407
Inventor 何前军范明俭金召奎赵鹏赫温艳媛
Owner SHENZHEN UNIV