Monoalkyl phosphate (salt) vesicle and preparation and application thereof
A monoalkyl phosphate and vesicle technology, which is applied in the field of monoalkyl phosphate vesicles and their preparation, can solve the problems of poor solubility, limited application and the like, and achieves low cost, simple and easy preparation method, and biocompatibility. Sexually superior effect
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Embodiment 1
[0048] Weigh 0.006-20 g of monolauryl phosphate monosodium salt and disperse it in 20 mL of water to obtain a white turbid dispersion system with a mass fraction of 0.03-50 wt.%, add 0.1-170.53 g (0.50-81 wt.%) of n-butanol, Its solubility is changed from 1.7×10 -4 wt.% increased to 0.03-13wt.%. figure 1 It is the ternary phase diagram of monolauryl phosphate monosodium salt / n-butanol / water and the apparent photograph of the single phase region. Depend on figure 1 It can be seen that monolauryl phosphate monosodium salt produces a clear and transparent single-phase region in the presence of cosolvent n-butanol Its apparent solubility can reach 13wt.% in the ternary system.
[0049] Weigh 0.006-0.048g of monolauryl phosphate monosodium salt, disperse it into 20mL of water to obtain a dispersion system with a mass fraction of 0.03-0.24wt.%, add n-butanol 0.10-1.65g (0.5-7.60wt.%) , shake, and vortex to get a series of vesicle solutions.
[0050] Negative stained TEM photog...
Embodiment 2
[0059] Weigh 0.006-2.3g of monolauryl phosphate monosodium salt and disperse it in 20mL water to obtain a white turbid dispersion system with a mass fraction of 0.03-10wt.%. Add 0.1-1.42g of n-amyl alcohol (0.50-6.00wt.% ), its solubility is changed from 1.7×10 -4 wt.% increased to 0.03-7wt.%.
[0060] Weigh 0.006-0.054g of monolauryl phosphate monosodium salt and disperse it in 20mL of water to obtain a dispersion system with a mass fraction of 0.03-0.27wt.%. Add 0.10-0.39g (0.50-1.9wt.%) of n-amyl alcohol , shake, and vortex to get a series of vesicle solutions.
[0061] Negative stained TEM photographs of vesicle samples as Image 6 As shown, monolauryl phosphate monosodium salt / n-amyl alcohol spontaneously formed vesicles, and the particle size of the vesicles ranged from 100 to 300 nm.
[0062] Monolauryl phosphate monosodium salt / n-pentanol vesicles are used as the molecular reactor of the enzyme cascade reaction, and UOX (uricase) and HRP (horseradish peroxidase) are...
Embodiment 3
[0068] Weigh 0.012-2.3 g of monomyristyl phosphate monopotassium salt and disperse it in 20 mL of water to obtain a white turbid dispersion system with a mass fraction of 0.06-10 wt.%. Add 0.002-0.46 g of guanidine hydrochloride (0.010-2.0 wt. % ), its solubility is changed from 1×10 -5 wt.% increased to 0.03-3.0wt.%.
[0069] Weigh 0.006-0.12 g of monomyristyl phosphate monopotassium salt, disperse it in 20 mL of water to obtain a dispersion system with a mass fraction of 0.03-0.60 wt.%, add 0.004-0.20 g of guanidine hydrochloride (0.020-1.0 wt.%) , shake, and vortex to get a series of vesicle solutions.
[0070] The monomyristyl phosphate-potassium salt / guanidine hydrochloride vesicle is used as the molecular reactor of the enzyme cascade reaction, and ChOx (choline oxidase) and HRP (horseradish peroxidase) are selected as the catalyst for the enzyme cascade reaction enzyme. Monomyristyl phosphate-potassium salt / guanidine hydrochloride vesicles encapsulating ChOx are deno...
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