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Chinese herbal medicine toothpaste having effect of repairing oral ulcer and preparation method of Chinese herbal medicine toothpaste

A Chinese herbal toothpaste and repairing technology, applied in the field of oral care, can solve the problems of darkening of the toothpaste, poor user compliance, low total flavonoid content, etc., and achieve the effects of less addition, favorable coloring and excellent curative effect.

Active Publication Date: 2019-07-02
JIANGSU SUZHONG PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ingredients in the extract of hollyhock flower are complex, and the content of total flavonoids is low. It is necessary to increase the amount of addition to increase the content of total flavonoids in toothpaste. However, increasing the amount of addition will lead to darker toothpaste paste and poor user compliance.

Method used

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  • Chinese herbal medicine toothpaste having effect of repairing oral ulcer and preparation method of Chinese herbal medicine toothpaste
  • Chinese herbal medicine toothpaste having effect of repairing oral ulcer and preparation method of Chinese herbal medicine toothpaste
  • Chinese herbal medicine toothpaste having effect of repairing oral ulcer and preparation method of Chinese herbal medicine toothpaste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A kind of Chinese herbal medicine toothpaste with oral ulcer repairing effect, comprises following preparation raw material components by weight:

[0057]

[0058] The rest is water.

[0059] The preparation method of the Chinese herbal medicine toothpaste comprises the following steps: dissolving the hollyhock flower extract, propolis extract and borneol in the formula amount into water, and stirring evenly; adding polyethylene glycol, hydrated silica and sodium lauryl sulfate in the formula amount , xanthan gum, xylitol, sodium benzoate, peppermint oil, and stir evenly; after vacuuming by a vacuum paste machine, grind for 25 minutes, vacuum degassing, add the vanillin of the formula, and grind for 18 minutes; Assemble, pack, and serve.

[0060] The preparation method of the hollyhock flower extract is as follows: take an appropriate amount of hollyhock flower, add 90% ethanol with a liquid-solid ratio of 16mL / g, heat and reflux for 1 hour, extract 2 times in total...

Embodiment 2

[0063] The only difference from Example 1 is that the preparation method of the hollyhock flower extract is different.

[0064] The preparation method of the hollyhock flower extract in this example is as follows: take an appropriate amount of hollyhock flower, add 90% ethanol with a liquid-solid ratio of 16mL / g, heat and reflux for 1 hour, extract 2 times in total, filter, concentrate the filtrate under reduced pressure, and dilute with water To a total flavonoid content of 5.0 mg / ml, purified by D101 macroporous resin, the ratio of resin column diameter to height is 1:6, the mass concentration of the sample solution is 5.0 mg / mL, pH5.0, and the sample volume is 3BV, 4BV water and 3BV Remove impurities with 5% ethanol, elute with 4BV of 60% ethanol, concentrate, dry, and pulverize to obtain a marshmallow flower extract, and the total flavonoid content in the extract is measured to be 70% by weight percentage.

[0065] Compared with Example 1, the Chinese herbal medicine tooth...

Embodiment 3

[0067] The only difference from Example 2 is that the Chinese herbal medicine toothpaste is prepared after further processing the hollyhock flower extract prepared in Example 2.

[0068] The processing method is as follows: after sequential gradient extraction with different proportions of ethyl acetate-ethanol mixtures, part of the extracts are combined and concentrated to dryness. Ethyl acetate-ethanol mixed solution is carried out gradient extraction by volume ratio successively according to 18:82, 38:62, 52:48, 68:32, and the extraction solution of combined volume ratio (18:82) and (68:32), The measured weight ratio of cottoncetin-3'-glucoside, quercetin-3'-glucoside or isoquercitrin is 13:4:5, concentrated and dried.

[0069] Compared with Example 1, the Chinese herbal medicine toothpaste prepared in this example has lighter color, improved transparency, easier molding and better stability.

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Abstract

The invention discloses a Chinese herbal medicine toothpaste having the effect of repairing oral ulcer and a preparation method of the Chinese herbal medicine toothpaste. The toothpaste comprises thefollowing components in parts by weight of 0.3-10 parts of an abelmoschus manihot corolla extract, 0.1-10 parts of a propolis extract and 0.1-5 parts of borneol. The abelmoschus manihot corolla extract, the propolis extract and the borneol are compounded to be used for preparing the Chinese herbal medicine toothpaste, and the three components mutually promote to exert synergistic effects, so thatthe Chinese herbal medicine toothpaste has good eliminating effect on oral inflammation, particularly has the repairing effect of diminishing inflammation, promoting healing and the like on the oral ulcer, cannot produce stimulation to skin and oral mucosa and can be used for a long term.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to a Chinese herbal medicine toothpaste with oral ulcer repairing effect and a preparation method thereof. Background technique [0002] 90% of adults in China have oral problems to varying degrees. Studies have shown that with changes in eating habits (numbing, spicy, hot) and increased work pressure, most adults have oral problems such as oral ulcers, gingival swelling, bleeding, and atrophy. Although these oral "minor problems" are not enough to go to the hospital, most of them bother people's emotions and have psychological and physical needs for quick solutions. Oral ulcer is one of the common damages in clinical oral cavity. Recurrent aphthous ulcer, Behcet's disease, traumatic ulcer, etc. can all lead to the occurrence of oral ulcer. Pain is obvious at the time of onset, which affects daily life such as eating, and brings great pain to patients. There is still no specifi...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/34A61Q11/00A61K36/185A61P1/02A61K31/045
CPCA61K8/988A61K8/97A61K8/34A61Q11/00A61K36/185A61K35/644A61K31/045A61K2800/805A61K2300/00
Inventor 唐海涛王丹丹赵耕先葛海涛陈俊
Owner JIANGSU SUZHONG PHARM GRP CO LTD