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A kind of anti-herpes virus gel and preparation method thereof
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An anti-herpes virus gel technology, applied in the field of anti-herpes virus gel and its preparation, achieves the effects of high percutaneous absorption rate, definite pharmacological effect, and less toxic and side effects
Active Publication Date: 2022-07-05
GUANGZHOU JINAN BIOMEDICINE RES & DEV CENT
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[0009] In order to overcome the defects of tetrahydroindazolone Hsp90 inhibitor drugdosage form in the prior art, the object of the present invention is to provide a kind of anti-herpes virus gel and preparation method thereof, to solve the above-mentioned problems
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Embodiment 1
[0034] Example 1. Preparation of amidation modified silk fibroin
[0035]Dissolving silk fibroin and amidoglycine in an aqueous urea solution with a concentration of 7 mol / L, the concentration of the aqueous urea solution of the silk fibroin is 10 mg / mL, and the concentration of the aqueous urea solution of the amidoglycine is 1 mol / L, Then adjust the pH to 4.75 with a hydrochloric acid solution with a concentration of 1.5mol / L, and then add 1-ethyl 3-(3-dimethylaminopropyl)carbodiimide with a concentration of 0.1mol / L at room temperature. The reaction was carried out for 1.5 h, and the hydrochloric acid solution of 1.5 mol / L was added dropwise during the reaction, and the pH of the reaction solution was kept at 4.75. After the reaction, the acetic acid buffer with a pH of 4.75 was added to decompose the excess 1-ethyl 3-( 3-dimethylaminopropyl) carbodiimide, then the reaction solution is dialyzed in deionized water, and freeze-dried to obtain it.
Embodiment 2
[0036] Embodiment 2, a kind of anti-herpes virus gel
[0037] Described anti-herpes virus gel is made up of following component and its weight percentage:
[0038] AT-533 0.02%, propylene glycol 50%, amidation modified silk fibroin 0.06%, carbomer type C 0.3%, triethanolamine 0.3% and water 49.32%; the amidation modified silk fibroin was prepared in Example 1 Amidation of silk fibroin.
[0041] S2 adds carbomer to the mixed solution I obtained in step S1 and stirs until it is completely dispersed, adds water and stirs until it is completely dissolved to obtain mixed solution II;
[0042] S3, adding triethanolamine and amidation modified silk fibroin to the mixed solution II obtained in step S2 and stirring evenly to obtain the result.
Embodiment 3
[0043] Embodiment 3, a kind of anti-herpes virus gel
[0044] Described anti-herpes virus gel is made up of following component and its weight percentage:
[0045] AT-533 0.04%, propylene glycol 60%, amidation modified silk fibroin 0.08%, carbomer type C 0.4%, triethanolamine 0.3% and water 39.18%; the amidation modified silk fibroin was prepared in Example 1 Amidation of silk fibroin.
[0046] The preparation method is similar to Example 2.
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Abstract
The invention belongs to the technical field of pharmacy, and in particular relates to an anti-herpes virus gel and a preparation method thereof. The anti-herpes virus gel is mainly composed of AT-533, propylene glycol, amidation modified silk fibroin, carbomer, triethanolamine and water. The anti-herpes virus gel provided by the invention has the advantages of high bioavailability, good stability, and is not easy to contaminate clothes, etc. At the same time, the anti-herpes virus gel also has no penetration enhancer, and the anti-viral drugabsorption effect is good. It has the advantages of low skinirritation, can effectively promote the healing of viral herpes, and shortens the healing time, so it is an ideal anti-herpes virusdrug formulation.
Description
technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an anti-herpes virus gel and a preparation method thereof. Background technique [0002] Herpes simplex virus (HSV) is a common pathogen that causes skin diseases and venereal diseases. According to different antigenicity, herpes simplex virus is divided into type I and type II herpes simplex virus. Herpes simplex virus type I (HSV-1) often causes cold sores on the lips or face, and can also infect the central nervous system. Herpes simplex virus type II (HSV-2) is mostly associated with genital infection or neonatal infection. Studies have shown that HSV is closely related to the spread of AIDS and is a pathogen that seriously endangers people's health. [0003] Varicella-zoster virus (VZV) is the causative agent of an acute, highly contagious varicella disease common in children. Shingles is caused by the reactivation of the latent virus in the body after the cu...
Claims
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