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Compound ceftiofur hydrochloride breast injectant

A technology of ceftiofur hydrochloride and udder injection, which is applied to the prescription and preparation field of compound ceftiofur hydrochloride udder injection for dairy cows, and can solve the problem that the drug cannot be guaranteed to reach the udder, the therapeutic effect cannot be achieved, and the drug distribution is uneven, etc. To achieve the effect of enriching traditional Chinese medicine resources, reducing antibiotic residues and drug resistance and other hazards, and inhibiting Staphylococcus aureus

Active Publication Date: 2019-07-30
ZHEJIANG HISUN ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the injection has to pass through multiple tissues when entering the breast, the curative effect is slow and more drugs cannot be guaranteed to reach the breast, so that a better therapeutic effect cannot be achieved; at the same time, most of the injections contain water, which will cause the product to appear Unstable phenomena such as stratification and uneven distribution of drugs seriously affect the efficacy of the product

Method used

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  • Compound ceftiofur hydrochloride breast injectant
  • Compound ceftiofur hydrochloride breast injectant
  • Compound ceftiofur hydrochloride breast injectant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) the prescription of every 100ml compound ceftiofur hydrochloride breast injection is as follows:

[0033]

[0034]

[0035] 2) Ceftiofur hydrochloride was pretreated by airflow micronization technology to obtain ceftiofur hydrochloride micropowder with a particle size of 5 μm.

[0036] 3) The non-aqueous solvent (soybean oil for injection) with 90% of the prescription amount is filtered, and the treated non-aqueous solvent is heated to 110° C. for later use.

[0037] 4) Add suspending agent hydrogenated castor oil and surfactant soybean lecithin into the above non-aqueous solvent until completely dissolved.

[0038] 5) When the temperature is cooled to 35°C, add the prescribed amount of ceftiofur hydrochloride; when the temperature continues to cool to 30°C, add the volatile oil of forsythia, and then add filtered non-aqueous solvent to 100ml.

[0039] 6) Process the prepared above solution with a high-speed disperser, and shear at 6000r / min for 20min.

[004...

Embodiment 2

[0042] 1) The prescription of compound ceftiofur hydrochloride breast injection per 100ml is as follows:

[0043]

[0044] 2) Ceftiofur hydrochloride was pretreated by airflow micronization technology to obtain ceftiofur hydrochloride micropowder with a particle size of 5 μm.

[0045] 3) Take 90% of the prescription amount of non-aqueous solvent (liquid paraffin) for filtration treatment, heat the treated non-aqueous solvent to 120° C., and set aside.

[0046] 4) Add the suspending agent aluminum stearate and the surfactant cetearyl ether B1 into the non-aqueous solvent until completely dissolved.

[0047] 5) When the temperature is cooled to 35°C, add the prescribed amount of ceftiofur hydrochloride; when the temperature continues to cool to 30°C, add the volatile oil of forsythia, and then add filtered non-aqueous solvent to 100ml.

[0048] 6) Process the prepared above solution with a high-speed disperser, and shear at 8000r / min for 20min.

[0049] 7) Filling and steri...

Embodiment 3

[0051] The prescription of compound ceftiofur hydrochloride breast injection per 100ml is as follows:

[0052]

[0053] 1) Get 90% of the non-aqueous solvent (soybean oil for injection) of the prescription amount to filter, and heat the processed non-aqueous solvent to 100°C for subsequent use.

[0054] 2) Add suspending agent hydrogenated castor oil and surfactant cetearyl ether B2 into the non-aqueous solvent until completely dissolved.

[0055] 3) When the temperature is cooled to 35°C, add the prescribed amount of ceftiofur hydrochloride; when the temperature continues to cool to 30°C, add the volatile oil of forsythia, and then add the filtered non-aqueous solvent to 100ml.

[0056] 4) Process the prepared above solution with a high-speed disperser, and shear at 10000r / min for 20min.

[0057] 5) Filling and sterilizing to obtain the product.

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Abstract

The invention relates to a prescription of a directional deep permeation-type compound ceftiofur hydrochloride breast injectant for cows and a preparation method of the injectant. The prescription iscomposed of the ceftiofur hydrochloride and a traditional Chinese medicine fructus forsythiae volatile oil through Chinese and Western cooperation, components such as a surfactant, a suspending agentand a non-water-soluble solvent are added, and through a special technology, a suspension with fine appearance is prepared. The preparation technology is simple and suitable for amplification production, and through an airflow micronization technology for treatment, in cooperation with a high-speed dispersion cutting technology, the prepared product is small in particle diameter and even and finein character; the prescription contains the surfactant so that the medicine can more evenly and deeply permeate into the breast to achieve the better treatment effect.

Description

[0001] Technical field: [0002] The invention belongs to the field of veterinary drug preparations, and in particular relates to a prescription of compound ceftiofur hydrochloride udder injection for cows and a preparation method thereof. [0003] Background technique: [0004] Mastitis (Bovine mastitis) is considered to be one of the most common diseases of dairy cows in developed countries, which seriously affects the economic benefits of the dairy industry and endangers the dairy farming industry. Cow mastitis not only reduces milk production and changes the quality of dairy products, but also indirectly affects human health. At present, the treatment of cow mastitis at home and abroad mainly focuses on antibiotic treatment, and has achieved good curative effect. However, due to the long-term use of antibiotics, the drug resistance of bacteria has increased, and the excess of antibiotic residues has endangered human health to a certain extent. Therefore, it is still necessa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K31/546A61K9/00A61K47/24A61K47/08A61P15/14A61P31/04
CPCA61K9/0019A61K47/24A61K47/08A61K31/546A61K36/634A61P15/14A61P31/04A61K2300/00
Inventor 张燕冀伟谢等龙王以跃王盈峰梁瑾童南森徐红波
Owner ZHEJIANG HISUN ANIMAL HEALTH PROD CO LTD
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