A kind of preparation method of expandable inorganic bone cement
A technology of bone cement and calcium phosphate bone cement, which can be used in pharmaceutical formulations, prostheses, drug delivery, etc., and can solve problems such as poor porosity and volume shrinkage of bone cement
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[0028] A kind of preparation method of expandable inorganic bone cement of the present invention, specifically implement according to the following steps:
[0029] Step 1: Put polyethylene glycol 6000 in a beaker at a temperature of 60°C-80°C for heating and melting in a water bath, add bicarbonate powder that has been pulverized and passed through a 60-mesh sieve to 80 mesh, and melt the melted polyethylene glycol 6000 is mixed with bicarbonate powder, and the volume is measured by the Archimedes drainage method. The volume ratio of polyethylene glycol 6000 and bicarbonate powder is 2-5:1-3. Stir evenly, pulverize after cooling, and pass through 45 Mesh-60 mesh screening, the thickness of polyethylene glycol 6000 layer coated with bicarbonate is 50 μm-100 μm.
[0030] The bicarbonate is sodium bicarbonate, potassium bicarbonate or calcium bicarbonate.
[0031] Step 2, preparing a foaming agent, measuring the volume by the Archimedes drainage method, respectively measuring 30...
Embodiment 1
[0039]Step 1, put polyethylene glycol 6000 in a beaker at 60°C for heating and melting in a water bath, add crushed sodium bicarbonate powder that has passed through a 60-mesh sieve, and mix the melted polyethylene glycol 6000 with sodium bicarbonate Mixing, using the Archimedes drainage method to measure the volume, polyethylene glycol 6000 and sodium bicarbonate at a volume ratio of 2:1, stirring evenly, and pulverizing after cooling through a 45-mesh sieve to obtain polyethylene glycol coated with sodium bicarbonate. Alcohol 6000 layer thickness is 50 μm.
[0040] Step 2, prepare foaming agent, adopt the Archimedes drainage method to measure the volume by volume percentage, measure the sodium bicarbonate 30% that obtains coating in step 1, citric acid 70% respectively, the volume percentage of above each component The sum is 100%, mix well to obtain foaming agent;
[0041] Step 3, prepare the solid phase powder of the expandable inorganic bone cement precursor, measure the...
Embodiment 2
[0045] Step 1, put polyethylene glycol 6000 in a beaker at 80°C for heating and melting in a water bath, add crushed potassium bicarbonate powder that has passed through a 80-mesh sieve, and mix the melted polyethylene glycol 6000 with potassium bicarbonate Mixing, using the Archimedes drainage method to measure the volume, polyethylene glycol 6000 and potassium bicarbonate at a volume ratio of 3:2, stirring evenly, and pulverizing through a 60-mesh sieve after cooling to obtain polyethylene glycol coated with potassium bicarbonate Alcohol 6000 layer thickness is 100 μm.
[0046] Step 2, prepare foaming agent, by volume percentage, adopt Archimedes drainage method to measure volume, measure step 1 respectively to obtain coated potassium bicarbonate 40%, tartaric acid 60%, the sum of above each component volume percentage 100%, mix evenly to obtain foaming agent;
[0047] Step 3, prepare the solid phase powder of the expandable inorganic bone cement precursor, measure the volu...
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