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Copper ion-directed aluminum-based metal-organic framework materials, preparation methods and applications thereof

An organic framework and copper ion technology, applied in the preparation of organic compounds, organic chemistry, analytical materials, etc., can solve the problems of expensive equipment, time-consuming, complicated operation, etc., achieve low detection limit, rich application fields, and simple detection process Effect

Active Publication Date: 2022-02-11
YANGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, the application of MOFs in the field of sensing can improve the current situation of expensive equipment, complicated operation and time-consuming detection of cancer markers.

Method used

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  • Copper ion-directed aluminum-based metal-organic framework materials, preparation methods and applications thereof
  • Copper ion-directed aluminum-based metal-organic framework materials, preparation methods and applications thereof
  • Copper ion-directed aluminum-based metal-organic framework materials, preparation methods and applications thereof

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preparation example Construction

[0039] As an aspect of the technical solution of the present invention, it relates to a method for preparing a copper ion-directed aluminum-based metal-organic framework material, which includes:

[0040] The uniformly mixed reaction system including the ligand, the aluminum ion, the copper ion and the solvent is reacted at 150° C. to 250° C. for 1 to 3 days to obtain the aluminum-based metal-organic framework material guided by the copper ion.

[0041] In one embodiment, the molar ratio of the ligand, aluminum ions and copper ions is 5:(1-5):m, wherein 0<m≦4.

[0042] Further, the molar ratio of the ligand, aluminum ion and copper ion can be 5:4:1, 5:3:2, 5:2.5:2.5, 5:2:3, 5:1:4, etc., but Not limited to this.

[0043] Further, the aluminum ions are derived from aluminum nitrate nonahydrate, but not limited thereto.

[0044] Further, the copper ions are derived from copper nitrate trihydrate, but not limited thereto.

[0045] Further, the ligands include trimellitic acid (...

Embodiment 1

[0081] Preparation method of copper ion-guided aluminum-based metal-organic framework material MIL-96: Al(NO with a molar ratio of 3:2:5 3 ) 3 · 9H 2 O, Cu(NO 3 ) 2 ·3H 2 O, H 3 A mixture of BTC and deionized water and methanol at a volume ratio of 1:1 was placed in a 100 mL Teflon liner and stirred at room temperature until a stable solution was obtained. The mixture was stirred for 1 hour and placed in a stainless steel autoclave , and placed in a preheated oven at 150°C for 3 days. After cooling, the product was collected by centrifugation (12000 rpm, 3 minutes) and washed with deionized water and ethanol. Finally, vacuum dry at 80°C for 6 hours. and named the product M 3:2 (x, y represent Al(NO 3 ) 3 9H 2 O and Cu(NO 3 ) 2 ·3H 2 O molar ratio).

Embodiment 2

[0083] The preparation method of copper ion-guided aluminum-based metal-organic framework material MIL-96: Al(NO 3 ) 3 9H 2 O, Cu(NO 3 ) 2 ·3H 2 O, H 3 A mixture of BTC and deionized water and ethanol at a volume ratio of 4:1 was placed in a 100 mL Teflon liner and stirred at room temperature until a stable solution was obtained. The mixture was stirred for 1 hour and placed in a stainless steel autoclave , and placed in a preheated oven at 200°C for 2 days. After cooling, the product was collected by centrifugation (12000 rpm, 3 minutes) and washed with deionized water and ethanol. Finally, it was vacuum dried at 50°C for 48 hours. and named the product M 2.5:2.5 (x, y represent Al(NO 3 ) 3 9H 2 O and Cu(NO 3 ) 2 ·3H 2 O molar ratio).

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Abstract

The invention discloses a copper ion guiding aluminum-based metal-organic framework material, a preparation method and application thereof. The preparation method comprises: reacting a uniformly mixed reaction system comprising ligands, aluminum ions, copper ions and solvents to obtain a copper ion-directed aluminum-based metal-organic framework material, which has a regular octahedron shape and uniform size. In the present invention, copper ions are used as the directing agent for the controllable synthesis of aluminum-based metal-organic framework materials. The doping of copper ions affects the growth of different crystal planes between the metal and the ligand during the material growth process, thereby realizing the change of the material morphology. And by increasing the amount of copper ions added, the growth of crystal nuclei of the material can be suppressed, the size of the material can be controlled, and the electrical conductivity can be improved. The preparation method of the electrochemical aptamer sensor of the present invention is simple, shows excellent sensitivity in the detection of alpha-fetoprotein, and has good selectivity, repeatability, stability and applicability to actual samples.

Description

technical field [0001] The present invention relates to a controllable synthesis of a metal-organic framework material, in particular to an octahedral aluminum-based metal-organic framework material (MIL-96) synthesized with different proportions of copper ions as a directing agent, and the material is synthesized in a The invention relates to an application in sensitive detection of fetal protein (AFP), which belongs to the technical field of metal organic framework materials. Background technique [0002] In recent decades, metal-organic frameworks (MOFs) have been reported in catalysis, gas storage, separation, drug delivery, Sensing and other fields have great application prospects (D.Shi, R.Zheng, M.-J.Sun, X.Cao, C.-X.Sun, C.-J.Cui, C.-S.Liu , J.Zhao, M.Du, Angew.Chemie Int.Ed.2017, 56, 14637; Z.Hu, B.J.Deibert, J.Li, Chem.Soc.Rev.2014, 43, 5815; X.Xiao, Q .Li,X.Yuan,Y.Xu,M.Zheng,H.Pang,SmallMethods 2018,2,1800240; P.-Q.Liao,J.-Q.Shen,J.-P.Zhang,Coord.Chem . Rev. 20...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/41C07C63/307G01N27/327
CPCC07C51/418G01N27/3277G01N27/327C07C63/307
Inventor 庞欢刘春森谷超男彭钰
Owner YANGZHOU UNIV