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A kind of preparation method of bletilla striata dressing with embedded structure

A technology of embedding structure and bletilla striata, which can be applied in medical formulations, bandages, drug delivery, etc., can solve problems such as difficult to apply wounds, unfavorable dressings, and difficult access, and achieve efficient hemostasis, antibacterial and healing effects, and solve Adhesion is difficult to disengage, and the chimera effect is reliable

Active Publication Date: 2021-08-17
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not easy to take when used, the surface layer is easy to dissolve, and it is not easy to stick to the wound, which reduces its hemostatic effect and wound healing speed
[0004] The existing Bletilla striata dressing will dissolve and stick because of the blood on the gloves worn by doctors during surgical operations, which is not conducive to the application of the dressing on the wound

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] A kind of preparation method of bletilla striata dressing with embedded structure, described preparation method is carried out according to the following steps:

[0030] a Preparation of Bletilla striata polysaccharide casting solution

[0031] The bletilla striata polysaccharide solution is prepared by dissolving the bletilla striata polysaccharide in water to prepare a bletilla striata polysaccharide solution with a mass fraction of 3-10%, and placed in a vacuum state with a vacuum degree of 0.1-0.5 MPa to remove air bubbles to obtain a bletilla striata polysaccharide casting solution for future use.

[0032] b Preparation of aqueous sodium hydroxide solution

[0033] Dissolving sodium hydroxide in water to prepare an aqueous sodium hydroxide solution with a mass fraction of 1-4%, stirring evenly, and cooling to room temperature.

[0034] c Preparation of embedded layer casting solution

[0035]Take part of the Bletilla striata polysaccharide casting solution prepar...

Embodiment 1

[0045] a Preparation of Bletilla striata polysaccharide casting solution

[0046] Dissolving Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 3%, and placing it in a vacuum with a degree of vacuum of 0.1 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide casting solution for future use.

[0047] b Preparation of aqueous sodium hydroxide solution

[0048] Sodium hydroxide was dissolved in water to prepare an aqueous sodium hydroxide solution with a mass fraction of 1%, stirred evenly, and cooled to room temperature.

[0049] c Preparation of embedded layer casting solution

[0050] Take part of the Bletilla striata polysaccharide casting solution prepared in step a, and add the sodium hydroxide solution prepared in step b dropwise at a speed of 0.3ml / min to the Bletilla striata polysaccharide casting solution stirred at a speed of 200r / min, and after stirring for 2 hours, Place in an envi...

Embodiment 2

[0057] a Preparation of Bletilla striata polysaccharide casting solution

[0058] Dissolving the Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 10%, and placing it in a vacuum state with a vacuum degree of 0.5 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide casting solution for future use.

[0059] b Preparation of aqueous sodium hydroxide solution

[0060] Sodium hydroxide was dissolved in water to prepare an aqueous sodium hydroxide solution with a mass fraction of 4%, stirred evenly, and cooled to room temperature.

[0061] c Preparation of embedded layer casting solution

[0062] Take part of the Bletilla striata polysaccharide casting solution prepared in step a, and add the sodium hydroxide solution prepared in step b dropwise at a speed of 1.0ml / min to the Bletilla striata polysaccharide casting solution stirred at a speed of 500r / min, and after stirring for 5h, Place in an e...

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PUM

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Abstract

The invention relates to a preparation method of bletilla striata dressing with embedded structure, belonging to the technical field of biomedicine. Preparation method Dissolve Bletilla striata polysaccharide in water to prepare casting solution, take part of Bletilla striata polysaccharide casting solution, treat with sodium hydroxide to obtain embedded layer casting solution, freeze Bletilla striata polysaccharide casting solution to form Bletilla striata polysaccharide-type film, and add Bletilla striata polysaccharide Groove is made on the surface of the film, and the casting solution of the embedded layer is poured on the surface of the groove of the polysaccharide-type film of Bletilla striata, and the embedded structural Bletilla striata dressing-type film is obtained through low temperature, and the embedded structural Bletilla striata dressing is obtained after freeze-drying. The invention utilizes notching method and freezing method to prepare the bletilla striata dressing with embedded structure, which overcomes the problems that the bletilla striata dressing is easy to dissolve and stick to gloves when it is taken, and it is difficult to detach from the wound when it is applied. The bletilla striata dressing obtained in the invention can be degraded and absorbed in the body, has good compatibility with organisms, and has no side effect on wounds.

Description

technical field [0001] The invention relates to a preparation method of bletilla striata dressing with embedded structure, belonging to the technical field of biomedicine. Background technique [0002] In the clinical use of surgery, the rapid hemostasis of the wound has an important impact on the postoperative recovery of patients. The existing Bletilla striata dressing is mainly made into a porous structure to improve its water absorption, and then enhance its hemostatic performance, so that the medicinal effect of Bletilla striata polysaccharide, a component of the Bletilla striata dressing, can be fully exerted. Bletilla striata polysaccharide provides a moist environment for the wound after swelling, accelerates wound healing, and can inhibit the formation of scars. [0003] The Chinese patent publication number is CN106075551A, the publication date is November 09, 2016, and the title of the invention is a preparation method of an interpenetrating network type Bletilla...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/64A61L15/44A61L15/46
CPCA61L15/28A61L15/42A61L15/425A61L15/44A61L15/46A61L15/64A61L2300/232A61L2300/404A61L2300/412A61L2400/04C08L5/00
Inventor 杨红军王晗汪林锋马思甜张骞陈欣庄燕徐卫林
Owner WUHAN TEXTILE UNIV