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A nadh drug-loaded microsphere

A technology of drug-loaded microspheres and weight ratio, which is used in drug combinations, pharmaceutical formulations, allergic diseases, etc., can solve the problems of expensive excipients, acid-intolerant half-life, low absorption and utilization rate, etc., and improve hypoxia tolerance. power, low production cost and high safety

Active Publication Date: 2021-09-21
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are NADH oral preparations on the market, but the preparation process of these oral preparations is very complicated, and the excipients used are not only expensive but also low in safety. After oral administration, most of them are degraded in the stomach, resulting in low absorption rate and short dosing intervals

Method used

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  • A nadh drug-loaded microsphere
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  • A nadh drug-loaded microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] The preparation method is as follows: Take 100g of NADH, 500g of palm oil, 150g of lard, 150g of beeswax, and 100g of proanthocyanidins, mix the above materials, stir and heat to 75°C to melt, the heating time is 20min, and the stirring speed is 200r / min (the heating temperature is too high, Too long time is not conducive to the stability of NADH); then the melted material enters the spray drying tower through a peristaltic pump, selects a 1.00mm nozzle, and controls the flow rate of the peristaltic pump to be 800mL / h (feeding speed has a great influence on the appearance and particle size of the particles). Uniformity and fluidity have important influences), the temperature of the nozzle is 110°C (the temperature of the nozzle must be slightly higher than the temperature of the material, otherwise the material is easy to solidify at the nozzle and cause blockage), the atomization pressure is 500Kpa (the atomization pressure is mainly Affect the particle size...

Embodiment 2

[0029]

[0030] The preparation method is as follows: Take 100g of NADH, 600g of soybean oil, 200g of cod liver oil, 50g of beeswax, and 50g of tea polyphenols, mix the above materials, stir and heat to 85°C to melt, the heating time is 15min, and the stirring speed is 100r / min; then the melted The material enters the spray drying tower through the peristaltic pump. The 1.00mm nozzle is selected, the flow rate of the peristaltic pump is controlled to 600mL / h, the temperature of the nozzle is 120°C, and the atomization pressure is 800Kpa, so that the melted material is atomized, and at the same time from the spray drying The bottom of the tower is fed with liquid nitrogen, and the atomized droplets are quickly cooled and solidified by the liquid nitrogen to form drug-loaded microspheres.

Embodiment 3

[0032]

[0033] The preparation method is as follows: Take 100g of NADH, 300g of olive oil, 200g of lard, 300g of laurel wax, and 100g of vitamin C, mix the above materials, stir and heat to 60°C to melt, the heating time is 60min, and the stirring speed is 150r / min; The final material enters the spray drying tower through a peristaltic pump. A 1.00mm nozzle is selected, and the flow rate of the peristaltic pump is controlled to 1000mL / h. The bottom of the drying tower is fed with liquid nitrogen, and the atomized droplets are quickly cooled and solidified by the liquid nitrogen to form drug-loaded microspheres.

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Abstract

The invention discloses an NADH drug-loaded microsphere, which is composed of the following ingredients in the weight ratio: NADH 1-20%; oil 50-80%; wax 5-30%; antioxidant 5-30%. The invention solves the technical problem that NADH is unstable in chemical properties and prone to degradation during the preparation process. NADH is melted in oil and wax with relatively stable physical and chemical properties, and antioxidants are added, and then formed by atomization cooling. , it not only effectively prevents the degradation of NADH, but also improves the particle size uniformity, dispersion and fluidity of the drug-loaded microspheres, and also has the advantages of simple and easy process and low production cost.

Description

technical field [0001] The invention relates to NADH drug-loaded microspheres, belonging to the field of health food. Background technique [0002] NADH (Nicotinamide adenine dinucleotide) is located at the first place in the respiratory chain and is the most important and energy-rich electron carrier for human metabolism. It plays an irreplaceable role in the production of cellular energy and cellular regulation, and plays a central role in cellular energy production. The NADH molecule is a control marker in the energy production chain in the mitochondria, a coenzyme of various hydrogen transferases (dehydrogenases, oxidoreductases), and plays an important role in brain, heart, blood vessel and muscle cells. [0003] NADH is sensitive to light, oxygen, and acidic conditions, so it is very unstable. Until a few years ago, it was not possible to use NADH by infusion. At present, there are NADH oral preparations on the market, but the preparation process of these oral prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/7084A61K47/44A61P25/20A61P25/28A61P37/04A61P39/00A61P39/06
CPCA61K9/1617A61K31/7084A61P25/20A61P25/28A61P37/04A61P39/00A61P39/06
Inventor 王运方秋杰胡珊叶小舟叶建锋
Owner HUAZHONG AGRI UNIV
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