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Porous titanium alloy surface bioglass/polycaprolactone/collagen coating and preparation method thereof

A technology of bioglass and polycaprolactone, which is applied in coating, tissue regeneration, medical science, etc., can solve the problems of lack of osteoinductivity of titanium alloy and reduce host rejection, so as to improve biocompatibility and tissue repair Ability, good for growth, high spraying efficiency

Inactive Publication Date: 2019-10-01
GUANGZHOU TRAUER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Titanium alloys lack good osteoinductivity, and its surface inert oxide layer limits its integration with surrounding bone tissue while reducing host rejection

Method used

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  • Porous titanium alloy surface bioglass/polycaprolactone/collagen coating and preparation method thereof
  • Porous titanium alloy surface bioglass/polycaprolactone/collagen coating and preparation method thereof

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Embodiment 1

[0028] As an embodiment of the preparation method of the porous titanium alloy surface bioglass / polycaprolactone / collagen coating described in the present invention, the porous titanium alloy surface bioglass / polycaprolactone / collagen coating described in this embodiment The preparation method of the layer comprises the following steps:

[0029] (1) Bioglass is mixed with hexafluoroisopropanol, ultrasonic 1h, the chemical composition SiO of described bioglass 2 :P 2 o 5 : CaO molar ratio is 61:4:35;

[0030] (2) Collagen and polycaprolactone are added in the hexafluoroisopropanol after ultrasonic in the step (1), and magnetic force is stirred 6h under the room temperature, obtain bioglass / polycaprolactone / collagen mixed solution, described bioglass / In the polycaprolactone / collagen mixed solution, the mass fraction of polycaprolactone is 10%, the mass fraction of collagen is 2%, and the mass fraction of bioglass is 16%;

[0031] (3) Use acetone, ethanol, and pure water to ...

Embodiment 2

[0034] As an embodiment of the preparation method of the porous titanium alloy surface bioglass / polycaprolactone / collagen coating described in the present invention, the porous titanium alloy surface bioglass / polycaprolactone / collagen coating described in this embodiment The preparation method of the layer comprises the following steps:

[0035] (1) Mix bioglass with hexafluoroisopropanol, ultrasonic 3h, the chemical composition SiO of described bioglass 2 :P 2 o 5 : CaO molar ratio is 55:5:40;

[0036] (2) Collagen and polycaprolactone are added in the hexafluoroisopropanol after ultrasonic in the step (1), under room temperature magnetic stirring 5h, obtain bioglass / polycaprolactone / collagen mixed solution, described bioglass / In the polycaprolactone / collagen mixed solution, the mass fraction of polycaprolactone is 5%, the mass fraction of collagen is 1%, and the mass fraction of bioglass is 15%;

[0037] (3) Use acetone, ethanol, and pure water to ultrasonically clean t...

Embodiment 3

[0040] As an embodiment of the preparation method of the porous titanium alloy surface bioglass / polycaprolactone / collagen coating described in the present invention, the porous titanium alloy surface bioglass / polycaprolactone / collagen coating described in this embodiment The preparation method of the layer comprises the following steps:

[0041] (1) Mix bioglass with hexafluoroisopropanol, ultrasonic 2h, the chemical composition SiO of described bioglass 2 :P 2 o 5 : CaO molar ratio is 65:2:33;

[0042] (2) Collagen and polycaprolactone are added in the hexafluoroisopropanol after ultrasonic in the step (1), under room temperature magnetic stirring 44h, obtain bioglass / polycaprolactone / collagen mixed solution, described bioglass / In the polycaprolactone / collagen mixed solution, the mass fraction of polycaprolactone is 15%, the mass fraction of collagen is 4%, and the mass fraction of bioglass is 20%;

[0043] (3) Use acetone, ethanol, and pure water to ultrasonically clean...

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Abstract

The invention discloses a porous titanium alloy surface bioglass / polycaprolactone / collagen coating and a preparation method thereof. By combining with an electrostatic spraying technology, a bioglass / polycaprolactone / collagen coating is constructed on a porous titanium alloy surface at the same time, the process is simple and convenient, the spraying efficiency is high, the bioglass / polycaprolactone / collagen coating is tightly combined with a titanium alloy substrate and does not easily shed off, and the coating can coexist with the micro-arc oxidation structure on the porous titanium alloy surface; furthermore, the bioglass / polycaprolactone / collagen coating improves the biocompatibility and tissue repair capability of a titanium alloy material, provides more stable chemical bonding and higher bioactivity for a titanium alloy implant, and is more beneficial to the ingrowth of new bone tissue.

Description

technical field [0001] The invention relates to the technical field of biomedical coatings, in particular to a bioglass / polycaprolactone / collagen coating on the surface of a porous titanium alloy and a preparation method thereof. Background technique [0002] Titanium alloys lack good osteoinductivity, and the inert oxide layer on its surface limits its integration with surrounding bone tissue while reducing host rejection. When titanium alloy materials are implanted in the body, common biological reactions mainly occur on the surface of the implant, so the surface biofunctionalization of titanium alloys has attracted extensive attention from researchers. [0003] The surface biofunctionalization of titanium alloys can not only maintain the mechanical properties of titanium alloys, but also significantly improve the osseointegration performance of implants and improve the success rate of implant surgery. Collagen composite technology on the surface of titanium alloy is anot...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/34A61L27/06A61L27/56
CPCA61L27/06A61L27/306A61L27/34A61L27/56A61L2430/02C08L89/00C08L67/04
Inventor 董亮亮陈淡嫦李奕恒罗思施
Owner GUANGZHOU TRAUER BIOTECH
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