Biologic 3D-printed implantation gel and application thereof to soft tissue defect repair

A 3D printing and composition technology, applied in tissue regeneration, drug delivery, medical science, etc., can solve problems such as deficiency, achieve the effects of avoiding the formation of effusion, promoting wound healing, and reducing the risk of infection

Active Publication Date: 2019-10-08
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For the repair of defective soft tissue, there is still a lack of effective methods in clinical practice, such as: materials that can fill soft tissue cavities, so that the soft tissue cavities formed after surgery can be filled, thereby promoting the healing of soft tissue at the trauma site

Method used

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  • Biologic 3D-printed implantation gel and application thereof to soft tissue defect repair
  • Biologic 3D-printed implantation gel and application thereof to soft tissue defect repair
  • Biologic 3D-printed implantation gel and application thereof to soft tissue defect repair

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Effect test

Embodiment 1

[0027] 2.5w / v% PEG, 20w / v% decellularized extracellular matrix, 15g / L hyaluronic acid, 2.5w / v% PEG+20w / v% decellularized extracellular matrix, 2.5w / v% PEG+ 15g / L hyaluronic acid, 20w / v% decellularized extracellular matrix + 15g / L hyaluronic acid, 2.5w / v% PEG + 5w / v% decellularized extracellular matrix + 15g / L hyaluronic acid, 2.5w / v% PEG+10w / v% acellular extracellular matrix+15g / L hyaluronic acid, 2.5w / v% PEG+20w / v% acellular extracellular matrix+15g / L hyaluronic acid, and blank control group After 10 groups were treated with gelation, 10 groups of rats (5 in each group) were implanted into the quadriceps femoris frostbite defect site, and the cross-sectional area of ​​the rat skeletal muscle was observed after 1 month as a way to judge the healing of the muscle defect. The basis of pros and cons, and corresponding statistical analysis, see image 3 . Such as image 3 As shown, the rats in the 2.5w / v% PEG+20w / v% decellularized extracellular matrix+15g / L hyaluronic acid gel...

Embodiment 2

[0029] Mix 2.5w / v% PEG, 20w / v% decellularized extracellular matrix and 15g / L hyaluronic acid solution, mix and stir for 24 hours to prepare PEG / decellularized extracellular matrix / hyaluronic acid hydrogel, which Store at 4°C. It is fluid at 4°C, suitable for injection, and becomes gelatinized at 37°C.

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Abstract

The invention relates to a composition. The composition comprises polyethylene glycol, cell-removed extracellular matrices and a hyaluronic acid solution, wherein the concentration of the polyethyleneglycol is 1.5w / v%-3.5%w / v, the concentration of the cell-removed extracellular matrices is 10w / v%-30w / v%, and the concentration of hyaluronic acid is 10g / L-20g / L. The composition disclosed by the invention has good biocompatibility, has a temperature-sensitive characteristic, and is gradually solidified along with rise of temperature; through a 3D printing technique, gel simulating the shape of extracellular matrices is prepared, adhesive attachment growth and regeneration repair of new granulation tissues in a cavity formed after a parenchyma resection operation are facilitated, and wound healing is promoted.

Description

technical field [0001] The present invention relates to a composition, in particular to a composition for implantation, which can be made into a gel for soft tissue repair. Background technique [0002] Malignant tumors are a highly lethal disease. Surgery is an effective way to treat malignant tumors. Tumor surgery often requires extensive resection of tumors and surrounding tissues, which means that huge soft tissue defects will result after surgery. After surgery, the cavity formed by the resection of soft tissue is very easy to form dead space, and fluid accumulation in the cavity increases the risk of complications such as postoperative infection, which is not conducive to wound regeneration and healing. [0003] Chinese invention patent application 201811170902.4 discloses a temperature-sensitive hydrogel for cartilage repair, including agarose aqueous solution, gelatin aqueous solution, sodium hyaluronate aqueous solution and DBM-RGD particles, wherein: the mass-volum...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/50A61L27/54A61L27/18A61L27/36A61L27/20B33Y10/00B33Y70/00
CPCA61L27/18A61L27/20A61L27/3633A61L27/3641A61L27/367A61L27/50A61L27/52A61L27/54A61L2300/252A61L2300/254A61L2300/30A61L2300/414A61L2300/418A61L2400/06A61L2430/30A61L2430/34B33Y10/00B33Y70/00C08L71/02C08L5/08
Inventor 贺超郝永强王磊
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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