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Preparation method for facilitation bone titanium tantalum composite

A composite material and bone-promoting technology, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve problems such as operation failure, increased medical costs, and insufficient mechanical properties, and achieves non-cytotoxicity, does not affect cell proliferation, and has excellent The effect of biocompatibility

Inactive Publication Date: 2019-10-08
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the lack of mechanical properties of titanium-tantalum composite materials obtained through casting and rolling in the existing technology, on the other hand, they are biologically inert materials. After implanted in the body, the bonding method with the human body's own bones is mostly mechanical bonds. It fails to bond with human cells and tissues, has poor compressive and tensile strength, and has a low degree of integration with the human body. increase medical costs
[0004] Patent (CN104342583A) mixes titanium powder and tantalum powder, presses and molds it to obtain a billet, and then prepares a titanium-tantalum composite material by vacuum sintering. Its mechanical properties have been improved, and it also has a certain biophase capacitative and then inducing osteogenic differentiation of preosteoblasts remains insufficient

Method used

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  • Preparation method for facilitation bone titanium tantalum composite
  • Preparation method for facilitation bone titanium tantalum composite
  • Preparation method for facilitation bone titanium tantalum composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 7:3; ball mill: ball material ratio is 4:1. 1mm < ball diameter < 5mm. The amount of powder loaded at one time = 100g. Sealed ball milling, vacuuming, vacuum degree <10Pa, filled with argon as protective gas, rotating speed 150r / min, ball milling time 18h. Then place the titanium-tantalum alloy powder in a discharge plasma sintering furnace for sintering. The sintering is completed to obtain a titanium-tantalum composite material. The sintering procedure is as follows: the heating rate is 70°C / min, the sintering temperature is 1000°C, and the sintering time is 5min; the sintering pressure 60MPa, air-cooled. The titanium-tantalum composite material was polished with 400 mesh, 600 mesh, 800 mesh, and 1200 mesh sandpaper until the surface was smooth without scratches, and then ultrasonically cleaned with ethanol, acetone, and deionized...

Embodiment 2

[0058] Prepare titanium-tantalum alloy powder, in which titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum: 2:1; sealed ball mill, vacuum, vacuum degree < 10Pa, filled with argon as protective gas, speed 150r / min , Ball milling time 15h. . Then the titanium-tantalum alloy powder is placed in a discharge plasma sintering furnace for sintering, and the sintering is completed to obtain a titanium-tantalum composite material. The sintering procedure is as follows: the heating rate is 70°C / min, the sintering temperature is 1300°C, and the sintering time is 15min; the sintering pressure 60MPa, air-cooled. The titanium-tantalum composite material was polished with 400 mesh, 600 mesh, 800 mesh, and 1200 mesh sandpaper until the surface was smooth without scratches, and then ultrasonically cleaned with ethanol, acetone, and deionized water in sequence, and dried.

[0059] In order to evaluate the toxicity of the titanium-tantalum composite material to c...

Embodiment 3

[0064] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 7:3; ball mill: ball material ratio is 4:1. 1mm < ball diameter < 5mm. The amount of powder loaded at one time = 100g. Sealed ball milling, vacuuming, vacuum degree <10Pa, filled with argon as protective gas, rotating speed 150r / min, ball milling time 18h. Then place the titanium-tantalum alloy powder in a discharge plasma sintering furnace for sintering. The sintering is completed to obtain a titanium-tantalum composite material. The sintering procedure is as follows: the heating rate is 70°C / min, the sintering temperature is 1000°C, and the sintering time is 5min; the sintering pressure 60MPa, air-cooled. The titanium-tantalum composite material was polished with 400 mesh, 600 mesh, 800 mesh, and 1200 mesh sandpaper until the surface was smooth without scratches, and then ultrasonically cleaned with ethanol, acetone, and deionized...

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Abstract

The invention discloses a preparation method for a facilitation bone titanium tantalum composite. According to the technical scheme, titanium powder and tantalum powder are subjected to ball milling and mixing, then discharge plasma sintering is conducted, polishing is conducted, and the facilitation bone titanium tantalum composite is obtained, has biocompatibility, does not have cytotoxicity, does not influence cell proliferation, and has good induction effect on osteogenic differentiation of preosteoblasts; and meanwhile alkali-heat-treatment is conducted on the titanium tantalum composite,rubidium is mixed into the surface of the titanium tantalum composite, bioactivity of the titanium tantalum composite can be further promoted, and the preosteoblasts are further facilitated and induced to differentiate to osteoblasts. If before alkali-heat-treatment, sand blasting treatment and acid treatment are conducted first, facilitation bone ability of the obtained facilitation bone titanium tantalum composite is more excellent.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a bone-promoting titanium-tantalum composite material. Background technique [0002] Knee osteoarthritis, hip fractures, and spinal degenerative diseases are all orthopedic diseases with a high incidence rate, and with the aging of the population, the incidence rate of the disease is increasing and younger. Titanium-tantalum composite materials are widely used in the field of clinical orthopedics because of their good mechanical properties, excellent biocompatibility and low cost. For example, joint replacement, spinal internal fixation and other common fracture treatment methods require the use of titanium-tantalum composite materials. material as a bone replacement material. [0003] However, due to the lack of mechanical properties of titanium-tantalum composite materials obtained through casting and rolling in the existing technology, o...

Claims

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Application Information

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IPC IPC(8): C22C1/04C22C14/00C22C27/02A61L27/06A61L27/50A61L27/56
CPCA61L27/06A61L27/50A61L27/56A61L2430/02C22C1/045C22C1/0458C22C14/00C22C27/02
Inventor 刘咏陈曼可谭彦妮黄千里
Owner CENT SOUTH UNIV
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