Preparation method of biologically active chronic wound auxiliary material and application thereof

A technology of biological activity and surface excipients, applied in medical science, bandages, etc., can solve the problems of multifunctional hydrogel dressings that have not been reported yet, and achieve chemical synthesis methods that are environmentally friendly, biocompatible, cheap and easy to obtain, and biocompatible good sex effect
CN110339392AInactive Publication Date: 2019-10-18XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2019-10-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a biologically active chronic wound auxiliary material and an application thereof. The method firstly prepares an epsilon-polylysine or polyethyleneimine functionalized polyether F127 polymer, and then oxidizes sodium alginate or pullulan by sodium periodate to obtain polysaccharide having an aldehyde group, a hydrogel having a three-dimensional network structure is formed by reacting a Schiff base between the cationic functionalized F127 polymer and the aldehyde-based polysaccharide, the exosomes are loaded into the hydrogel by electrostatic interaction with the cationic polymer, and the bioactive antibacterial and photodamage-resistant chronic wound auxiliary material can be prepared. The bioactive antibacterial and photodamage-resistant chronic wound auxiliary material prepared by the method has excellent mechanical properties such as temperature sensitivity, injectability and self healing, good antibacterial, anti-light damage and promotion of wound healing. Therefore, the hydrogel has the good application prospect in antibacterial, anti-light damage and promoting chronic wound healing.
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Description

technical field

[0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a preparation method and application of a bioactive chronic wound auxiliary material. Background technique

[0002] The high incidence of diabetes has become a serious problem that threatens the health and quality of life of patients. Hyperglycemia-induced microvascular dysfunction, one of the main causes of diabetic complications, often leads to wound ischemia and delayed healing in patients. Wound healing generally needs to go through four phases, namely, coagulation phase, inflammation phase, cell proliferation phase, and new tissue remodeling phase, and also requires nutrients and oxygen provided by blood vessels. Therefore, enhancing angiogenesis and revascularization in diabetic wounds is crucial to accelerate chronic wound healing. Traditional clinical treatments for diabetic wounds are glycemic control, surgical debridement, grafting,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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