A kind of transparent thermosensitive reversibly degradable polyester hydrogel with fast gel ability and preparation method thereof

Abstract

The invention relates to transparent, temperature-sensitive, reversible and biodegradable polyester hydrogel with fast gelling capability and a preparation method thereof. The polyester hydrogel is composed of biodegradable polyester and a medium, wherein the biodegradable polyester adopts multi-element triblock copolymer with special structure characteristics; the hydrogel is obtained through a polymerization process. Compared with similar temperature-sensitive hydrogel, the hydrogel provided by the invention is high in gelling speed and acute in temperature sensitivity, and can form gel in 1.5-15 minutes, which reduces the loss of the polyester hydrogel before and after applying the hydrogel, and facilitates uniform package of water insoluble functional substances. The hydrogel provided by the invention changes little in transparency before and after gelling, unlike common hydrogel which turns to a white turbid system after gelling; the absorbancy to light at 600 nm wavelength is 0.02-0.5 under the condition of 5 mm optical path length; the transparency is high; therefore, the polyester hydrogel is suitable for observing the packaging conditions of functional substances and observing and monitoring the releasing process of the functional substances.

Description

technical field [0001] The invention relates to a hydrogel and a preparation method thereof, which belong to the field of production and application of functional polymer materials, in particular to a transparent temperature-sensitive reversible degradable polyester hydrogel with rapid gel ability and a preparation method thereof. Background technique [0002] Hydrogel is a hydrophilic polymer network, which can absorb a large amount of water, but will not dissolve in water due to the physical cross-linking and chemical cross-linking between polymer chains, and can only swell and maintain a certain shape. Hydrogels have good biocompatibility and water permeability, and hydrogel materials with different microstructures and properties can be obtained through artificial synthesis. Due to the high water content, softness, rubber-like viscoelasticity, good biocompatibility and many other physical and chemical properties of hydrogel materials, they are widely used in medicine, phy...

AI Technical Summary

Problems solved by technology

The degradable polyester temperature-sensitive smart hydrogels that have emerged generally gel during a longer and slower heating process. After gelation, the system becomes white and turbid, and the gel cannot return to a sol when the temperature is lowered, which is a typical irreversible opacity. Gel, not suitable for repeated transformation applications, not suitable for fast setting applications, easy to cause phase separation of hydrophobic functional substances, not conducive to the loading of hydrophobic functional substances, not suitable for observation and research on the release of functional substances, The gel temperature often occurs in low temperature situations below body temperature, so it is not suitable for applications under high temperature gel conditions, and is not suitable for expanding to other fields such as functional material manufacturing.