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Antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as preparation method and application thereof

A hydrogel excipient, chronic wound technology, applied in medical science, bandages, etc., can solve the problems of inability to keep the wound moist, exogenous infection, limited clinical application, etc., to promote the healing of chronic wounds and good biocompatibility , the effect of good antibacterial properties

Active Publication Date: 2018-11-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most widely used traditional dressings are gauze, cotton pads and bandages. They have the advantages of low cost and simple manufacturing process, but they cannot keep the wound moist, and the granulation tissue is easy to grow into the mesh of the gauze. Disadvantages such as exogenous infection have greatly limited its application; natural synthetic dressings are obtained by processing and extracting natural materials, mainly animal skin dressings, collagen dressings and alginate dressings, although these Collagen-based dressings have certain excellent effects, but because animal skin-based dressings are difficult to solve rejection reactions, have poor revascularization and antibacterial properties, and collagen-based dressings have poor ability to absorb exudate, they are not suitable for exudative and infectious wounds. Such dressings need auxiliary fixation and are not suitable for dry or hard wounds. These shortcomings greatly limit their clinical application

Method used

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  • Antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as preparation method and application thereof
  • Antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as preparation method and application thereof
  • Antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1) Preparation of AHA polymer: Add 2 g of sodium hyaluronate into 100 mL of deionized water, stir vigorously to make it fully dissolve; after the sodium hyaluronate is completely dissolved, add sodium periodate at a molar ratio of 1:1, Stir and react at room temperature for 4 hours in the dark. Then add ethylene glycol with a sodium periodate molar ratio of 2:1 to terminate the reaction, after stirring for 1 hour, the reaction product (AHA) was dialyzed and purified in deionized water for 2 days, and freeze-dried was left for later use;

[0047] 2) Preparation of FHE-5 hydrogel: dissolve polyether F127 with a mass volume ratio of 20% (g / mL) and EPL with a mass volume ratio of 5% (g / mL) in 10 mM, pH 7.4 PBS buffer , shake vigorously in an ice bath to mix well, then add AHA with a mass volume ratio of 5% (g / mL), shake vigorously to mix well, and incubate in a water bath at 37°C for 1 hour to form a double A network-structured hydrogel (FHE-5), an antibacterial self-heali...

Embodiment 2

[0050] 1) Preparation of AHA polymer: Add 2 g of sodium hyaluronate into 100 mL of deionized water, stir vigorously to make it fully dissolve; after the sodium hyaluronate is completely dissolved, add sodium periodate at a molar ratio of 1:1, Stir and react at room temperature for 4 hours in the dark. Then add ethylene glycol with a sodium periodate molar ratio of 2:1 to terminate the reaction, after stirring for 1 hour, the reaction product (AHA) was dialyzed and purified in deionized water for 2 days, and freeze-dried was left for later use;

[0051] 2) Preparation of FHE-10 hydrogel: dissolve polyether F127 with a mass volume ratio of 20% (g / mL) and EPL with a mass volume ratio of 10% (g / mL) in 10 mM, pH 7.4 PBS buffer , shake vigorously in an ice bath to mix well, then add AHA with a mass volume ratio of 5% (g / mL), shake vigorously to mix well, and incubate in a water bath at 37°C for 1 hour to form a double A network-structured hydrogel (FHE-10), an antibacterial self-he...

Embodiment 3

[0054] 1) Preparation of AHA polymer: Add 2 g of sodium hyaluronate into 100 mL of deionized water, stir vigorously to make it fully dissolve; after the sodium hyaluronate is completely dissolved, add sodium periodate at a molar ratio of 1:0.5, Stir and react at room temperature for 4 hours in the dark. Then add ethylene glycol with a sodium periodate molar ratio of 2:1 to terminate the reaction, after stirring for 1 hour, the reaction product (AHA) was dialyzed and purified in deionized water for 2 days, and freeze-dried was left for later use;

[0055] 2) Preparation of FHE-15 hydrogel: dissolve polyether F127 with a mass volume ratio of 20% (g / mL) and EPL with a mass volume ratio of 15% (g / mL) in 10 mM, pH 7.4 PBS buffer , shake vigorously in an ice bath to mix well, then add AHA with a mass volume ratio of 5% (g / mL), shake vigorously to mix well, and incubate in a water bath at 37°C for 1 hour to form a double A network-structured hydrogel (FHE-15), an antibacterial self-...

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Abstract

The invention discloses an antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as a preparation method and application thereof. The method comprisesthe following steps: firstly oxidizing sodium hyaluronate, sodium alginate and pulullan through a strong oxidant to obtain polysaccharide with aldehyde group, then forming a polymer with network withcationic polymers such as epsilon-polylysine, polyethyleneimine and chitosan through Schiff base reaction, then fully mixing the polymer with F127 to form a hydrogel with a dual-network structure, finally loading exosome on the cationic polymers through electrostatic effect, coating the exosome in the hydrogel with the dual-network structure to obtain the antibacterial self-healing hydrogel dressing capable of accelerating healing of the chronic wounds. The preparation method is simple and is free of organic solvent residues; the used chemical synthesis method is environmentally friendly and is convenient to operate and low in raw material cost.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to an antibacterial self-healing hydrogel auxiliary material for promoting chronic wound healing and its preparation method and application. Background technique [0002] Wound is the damage of human tissues or organs caused by external injury factors such as surgery, external force, heat, low temperature, electric current, chemical substances and internal factors such as local blood supply disturbance. The healing process includes coagulation period, inflammation, etc. There are four stages: cell proliferation stage and new tissue remodeling stage. Healing speed is affected by many factors such as wound type, pathological condition and dressing type. With the continuous research of science and technology, wound dressing not only has the functions of protecting wound, stopping bleeding and preventing infection, but also has the function of promoti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/075C08L5/08C08L5/04C08L5/00C08L71/00C08L79/02C08L77/04
CPCA61L26/0014A61L26/0019A61L26/0023A61L26/008C08J3/075C08J2371/00C08J2479/02C08J2477/04C08J2405/08C08J2405/04C08J2405/00C08L5/08C08L5/04C08L5/00C08L77/04C08L39/00
Inventor 雷波王敏
Owner XI AN JIAOTONG UNIV
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