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Radix astragali flower and application of extractive of radix astragali flower in preparing medicine or health care products for preventing pulmonary fibrosis

A technology for pulmonary fibrosis and health care products, applied in the field of natural products that can prevent and treat pulmonary fibrosis and its preparation, can solve the problems of wasting resources of Astragalus membranaceus, achieve good prevention and treatment of pulmonary fibrosis, alleviate pathological changes, and reduce lung weight The effect of the coefficient

Inactive Publication Date: 2019-11-08
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to preliminary estimates, about 35,000 tons of by-products of Astragalus membranaceus can be produced every year because there is no effective way to use them, which brings about a huge waste of Astragalus membranaceus plant resources
At present, there is no technology to prepare active extracts from Astragalus flowers, and there are no reports of using Astragalus flowers as main components in medicines or health foods for the prevention and treatment of pulmonary fibrosis.

Method used

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  • Radix astragali flower and application of extractive of radix astragali flower in preparing medicine or health care products for preventing pulmonary fibrosis
  • Radix astragali flower and application of extractive of radix astragali flower in preparing medicine or health care products for preventing pulmonary fibrosis
  • Radix astragali flower and application of extractive of radix astragali flower in preparing medicine or health care products for preventing pulmonary fibrosis

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Experimental program
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Effect test

Embodiment 1

[0020] Example 1 Experimental Research on the Prevention and Treatment of Pulmonary Fibrosis Based on Model Animals

[0021] 1. Materials and Reagents

[0022] 1. Drugs and reagents

[0023] Bleomycin hydrochloride for injection (BLM, Hisun Pfizer Pharmaceutical Co., Ltd.). Hydroxyproline (HYP) detection kit (alkaline hydrolysis method), malondialdehyde MDA (TBA method), total antioxidant capacity T-AOC (FRAP method), mouse transforming growth factor β 1 (TGF-β 1 ) enzyme-linked immunoassay kit and mouse tumor necrosis factor-α (TNF-α) enzyme-linked immunoassay kit were provided by Nanjing Jiancheng Bioengineering Company. Prednisone acetate tablets were purchased from Zhejiang Xianju Pharmaceutical Co., Ltd.

[0024] Astragalus flowers are produced in Hunyuan County, Shanxi Province. According to Professor Duan Jinzhen of our school, they are derived from the flowers of the perennial herbaceous plant of the leguminous family Astragalus membranaceus.

[0025] 2. Instrumen...

Embodiment 2

[0058] Example 2 Experimental Research on Prevention and Treatment of Pulmonary Fibrosis Based on Cell Model

[0059] 1. Instruments and materials

[0060] 1. Instrument

[0061] CO 2 Incubator (SERIES II WATER JAVKET type, American Thermo Company); autoclave (TOMYSX-500 type, Nanjing Jitian Biotechnology Co., Ltd.); water bath (BWS-10 type, Kunshan Yiheng Instrument Co., Ltd.); Enspire Microplate reader (perkinelmer, USA); UV spectrophotometer (DU-650, Beckman); stabilized power supply (Bio-Rad); shaker (Thermo-Shaker); vertical electrophoresis apparatus (Bio-Rad); (Bio-Rad); gel imaging system (GelDOC2000, Bio-Rad), Panasonic ice machine.

[0062] 2. Materials

[0063] Quercetin, caffeic acid, kaempferol, isoquercitrin, protocatechuic acid and hyperin monomer reference substances were purchased from Nanjing Liangwei Biotechnology Co., Ltd., and the purity of the above chemicals detected by HPLC was greater than 98%. The preparation methods of the extracts AE, EE, DT, L...

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Abstract

The invention discloses a radix astragali flower and application of an extractive of the radix astragali flower in preparing medicine or health care products for preventing pulmonary fibrosis. The extractive of the radix astragali flower can effectively reduce lung weight coefficients of c57BL / 6 mice pulmonary fibrosis models caused by bleomycin, obviously reduce the MDA, HYP contents in lung tissue and TGF-beta1 and TNF-alpha in serum, increase the T-AOC content in the serum at the same time, and relieve the pathological change of model animal lung tissue; and cell experiments show that the extractive of the radix astragali flower can well protect HELF cells which are damaged by hydrogen peroxide. Experiments in vivo and vitro show that the extractive of the radix astragali flower can beused for treating the pulmonary fibrosis. Compared with existing medicine, the extractive takes a natural and traditional medicinal plant as a raw material, more safety is achieved, and adverse reaction does not exist,

Description

technical field [0001] The invention relates to a natural product, in particular to a natural product capable of preventing and treating pulmonary fibrosis, a preparation method and application thereof. Background technique [0002] Pulmonary fibrosis (PF) is a chronic lung disease characterized by alveolar interstitial inflammatory cell infiltration, fibroblast proliferation, and alveolar interstitial fibrous connective tissue deposition. . In recent years, the incidence of pulmonary fibrosis has been increasing. The average survival period of idiopathic pulmonary fibrosis after diagnosis is 2 to 4 years, and the 5-year survival rate is 30% to 50%. The prevalence rate in Europe and Japan is ( 3-8) / 100,000 population, the case fatality rate is 6.43 / 100,000 for males and 5.84 / 100,000 for females, both showing an upward trend. Currently, glucocorticoids and immunosuppressants are the first choice of chemical drugs for the treatment of pulmonary fibrosis, but they are only ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K31/715C08B37/00A61P11/00A61K133/00
CPCA61K31/715A61K36/481A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P11/00C08B37/0003
Inventor 郭盛段金廒朱悦李园钱大玮
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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