Shen bei intestine strengthening capsule beta-cyclodextrin inclusion method

A technology of beta-cyclodextrin and ginseng-gut, applied in the directions of capsule delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of drug irritation, toxic side effects, etc., to prevent volatilization, reduce irritation and toxic side effects, improve The effect of bioavailability

Inactive Publication Date: 2019-11-12
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at adding components such as petroleum ether and absolute ethanol to the existing clathrate preparation method, which are easy to mix with volatile oils. Although the utilization rate of the overall clathrate raw materials is improved, other components exist in the guest molecules in the final clathrate substance, there are certain problems of drug stimulation and risk of side effects, and a method for inclusion of beta-cyclodextrin in Shenbei Guchang Capsules is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The inclusion method of beta-cyclodextrin in Shenbei Guchang Capsules comprises the following production steps:

[0023] S1, clathrate raw material ingredients, select an appropriate amount of volatile oil and β-cyclodextrin;

[0024] S2, grinding, mixing the volatile oil and β-cyclodextrin, and putting them into a colloid mill for grinding to obtain a ground product;

[0025] S3, drying in the air, putting the ground material on a tray and drying it naturally at room temperature to obtain a dry product;

[0026] S4, pulverizing, pulverizing the dry matter through a pulverizer to obtain clathrates.

[0027] In use, without adding other organic components, directly put the volatile oil and β-cyclodextrin into the colloid mill for grinding, so that it can form the structure of the main molecule and the guest molecule of the clathrate. The main molecule has a larger The hole structure is enough to hold the guest molecule inside, forming a molecular capsule. After the vo...

Embodiment 2

[0029] The inclusion method of beta-cyclodextrin in Shenbei Guchang Capsules comprises the following production steps:

[0030] S1, clathrate raw material ingredients, select appropriate amount of volatile oil and β-cyclodextrin, 1 part of volatile oil, 9 parts of β-cyclodextrin, volatile oil is extracted from nutmeg (steamed), woody and herb;

[0031] S2, grinding, firstly mix the volatile oil and β-cyclodextrin evenly, then turn on the circulating water of the colloid mill, close the outlet, turn on the power, and then put the mixed volatile oil and β-cyclodextrin mixture into it for grinding , to obtain a grinding object, and the grinding time is 40min;

[0032] S3, dry in the air, spread the grinding material on the loading tray with a thickness of 1 cm, and dry it naturally at room temperature for 20 minutes to obtain a dry product;

[0033] S4, pulverizing, pulverizing the dry matter by a pulverizer, and the mesh size is 80 mesh, to obtain clathrate.

[0034] In use, w...

Embodiment 3

[0043] The inclusion method of beta-cyclodextrin in Shenbei Guchang Capsules comprises the following production steps:

[0044] S1, clathrate raw material ingredients, select appropriate amount of volatile oil and β-cyclodextrin, 1 part of volatile oil, 9 parts of β-cyclodextrin, volatile oil is extracted from nutmeg (steamed), woody and herb;

[0045] S2, grinding, firstly mix the volatile oil and β-cyclodextrin evenly, then turn on the circulating water of the colloid mill, close the outlet, turn on the power, and then put the mixed volatile oil and β-cyclodextrin mixture into it for grinding , to obtain a grinding object, and the grinding time is 20min;

[0046] S3, drying in the air, laying the grinding material on the loading tray with a thickness of 3 cm, drying naturally at room temperature, and the natural drying time is 40 minutes, to obtain a dry product;

[0047] S4, pulverizing, pulverizing the dry matter by a pulverizer with a mesh number of 100 mesh to obtain cl...

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PUM

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Abstract

The invention relates to the technical field of effective ingredients of medicine, in particular to a method for extracting volatile oil in a shen bei intestine strengthening capsule. The method includes the following steps that first, an appropriate amount of myristica fragrans (simmering), rhizoma atractylodis, and costusroot are selected, then the myristica fragrans (simmering) treatment is conducted, the myristica fragrans (simmering) is knocked or broken to prepare fragmentary myristica fragrans (simmering), the fragmentary myristica fragrans (simmering) is mixed with the rhizoma atractylodis and the costusroot, placed into an extraction tank for cold soak, and then extracted by heating steam, and then steam generated by S4 is introduced into an oil-water separator to condense and prepare a distillate, oil-water separation is conducted on the distillate to prepare the volatile oil, and based on the method, the problems that too much volatile oil is lost and the final verificationresult is affected due to the fact that oil chambers and oil-containing cells of some raw materials are destroyed caused by extraction after crushing of the raw materials to be extracted by an existing extraction method are solved.

Description

technical field [0001] The invention relates to the technical field of active ingredients of medicines, in particular to a method for inclusion of beta-cyclodextrin in Shenbei Guchang Capsules. Background technique [0002] Shenbei Guchang Capsule is a common Chinese patent medicine, which contains Chinese gall, nutmeg (steamed), myrobalan meat (simmered), ebony, woody, atractylodes, Poria cocos, antler cream, red ginseng. The effect of invigorating the spleen and warming the kidney. It is used for chronic diarrhea caused by spleen and kidney yang deficiency, abdominal pain, limb fatigue, mental fatigue, lazy speech, cold body and limbs, lack of food, sore waist and knees; irritable bowel syndrome (diarrhea type) see the above symptoms. [0003] In order to increase the solubility and stability of the drug, the effective volatile oil of the drug and cyclodextrin are often used to carry out inclusion complexes to obtain clathrates. The Chinese patent with the publication num...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K47/69A61K9/48A61P1/00A61P1/12A61P1/14A61P13/12A61K35/64A61K35/32
CPCA61K9/48A61K35/32A61K35/64A61K36/076A61K36/185A61K36/258A61K36/284A61K36/285A61K36/736A61K47/6951A61P1/00A61P1/12A61P1/14A61P13/12A61K2300/00
Inventor 吕文俊何念张晟
Owner GUIZHOU LIANSHENG PHARMA
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