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Application of ligusticum chuanxiong hort essential oil

A technology of Chuanxiong essential oil and Ligusticum chuanxiong, which is applied in the field of biomedicine to achieve the effects of improving metabolic stability, improving cognitive function, and increasing biological activity

Inactive Publication Date: 2019-11-15
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Application of ligusticum chuanxiong hort essential oil
  • Application of ligusticum chuanxiong hort essential oil
  • Application of ligusticum chuanxiong hort essential oil

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preparation example Construction

[0038] The preparation method of Chuanxiong essential oil of the present invention comprises steam distillation extraction and carbon dioxide supercritical extraction.

[0039] Rhizoma Chuanxiong essential oil of the present invention is detected by gas chromatography-mass spectrometry instrument, and its component ratio by mass percentage is: trans-ligustilide (trans-ligustilide) (>25%), β-cineole ( β-eudesmene) (>5%), senkyunolide (>6%), butylphthalide (>4%).

Embodiment 1

[0041] Take 100Kg of dried rhizomes of Ligusticum chuanxiong Hort., pile them up for 2 days, crush them to 50 mesh coarse particles, soak the coarse particles in 8 times the mass of hydrochloric acid aqueous solution with a pH value of 5.0, and extract overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain the essential oil of Ligusticum chuanxiong.

Embodiment 2

[0043] Take 50Kg of dried rhizomes of Ligusticum chuanxiong Hort., pile them up for 2 days, crush them to 50 mesh coarse particles, soak the coarse particles in 8 times the mass of hydrochloric acid aqueous solution with a pH value of 5.0, and extract overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixed solution into a carbon dioxide supercritical extraction instrument. The extraction temperature is 46°C, the pressure is 15.70MPa, the time is 85min, and the flow rate of carbon dioxide is 30kg / h; the essential oil is collected and refined in a molecular distillation instrument. The feed temperature was 43°C, the sample injection speed was 510mL / h, the first stage evaporation temperature was 112°C, and the second stage evaporation temperature was 63°C, and the second stage distillation part was collected to obtain Chuanxiong essential oil. ...

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Abstract

The invention discloses application of ligusticum chuanxiong hort essential oil, including application of ligusticum chuanxiong hort essential oil in preparation of drugs for treating or preventing brain dysfunctions and disorder diseases, and application of ligusticum chuanxiong hort essential oil in preparation of healthy products for improving brain dysfunctions and treating disorder diseases.According to the application, the novel application of the ligusticum chuanxiong hort essential oil in drugs or large healthy products showing activity in brain dysfunctions and disorder diseases of experimental animals is found for the first time, and it is found for the first time that the ligusticum chuanxiong hort essential oil or a composition containing the ligusticum chuanxiong hort essential oil or any ligusticum chuanxiong hort essential oil composition can alleviate or treat the symptoms of the brain dysfunctions and disorder diseases such as alzheimer's disease, depression and anxiety in in-vivo models of the animals. Compared with current drugs for treating brain dysfunctions and disorders, the ligusticum chuanxiong hort essential oil or any composition thereof has the mechanism of making polymolecular synergistic effects on multiple targets, for example, cholinesterase inhibiting and neurotransmitter regulating, has good pharmacokinetic parameters and easily permeates through the blood-brain barrier, so that the ligusticum chuanxiong hort essential oil has the advantages of improving toxicological safety and having stable metabolism, longer half-life and / or smaller side effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of chuanxiong essential oil in the preparation of medicines and health products for treating and preventing brain function and its disorders. Background technique [0002] Ligusticum chuanxiong Hort., an Umbelliferae plant, is currently mainly cultivated in Pengzhou, Dujiangyan and other places in Sichuan Province. The dried rhizome of Chuanxiong is a traditional Chinese medicinal material, which has been included in successive dynasties of herbal medicines. Ligusticum Chuanxiong has the effects of invigorating blood and promoting qi, dispelling wind and relieving pain. It is often used to treat chest obstruction and heart pain, tingling pain in the chest and hypochondrium, swelling pain in tumbling, irregular menstruation, amenorrhea dysmenorrhea, abdominal pain in the abdomen, headache, rheumatic arthralgia and other diseases. Chuanxiong mainly contains volatile o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61P25/22A61P25/24A61P25/20A61P25/08A61P25/18A61P21/02A61P9/10A61P25/14A61P25/00A61P25/28A61P25/16A61P21/00A61K8/92A61Q19/00C11B9/02A61K125/00
CPCA61K36/236A61P25/22A61P25/24A61P25/20A61P25/08A61P25/18A61P21/02A61P9/10A61P25/14A61P25/00A61P25/28A61P25/16A61P21/00A61K8/922A61Q19/00C11B9/02C11B9/022C11B9/025C11B9/027A61K2236/333A61K2236/19A61K2236/331A61K2236/37
Inventor 许敏陈淑霞韩佳欣李海舟杨崇仁
Owner KUNMING UNIV OF SCI & TECH
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