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Amphiphilic biochar compound with anti-bacterial and anti-coagulation properties and preparing method and application thereof

A carbon composite and biophilic technology, applied in anticoagulant treatment, carbon preparation/purification, drug delivery, etc., can solve the problems of short action time and inconvenient use of impregnation method, and achieve inhibition of catheter-related infection , good antibacterial properties, and the effect of inhibiting platelet adhesion

Inactive Publication Date: 2019-11-15
郑州欧姆康生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the coated urinary catheter has the effect of antithrombotic or antibacterial infection, the dipping method still has the disadvantages of short action time and inconvenient use.

Method used

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  • Amphiphilic biochar compound with anti-bacterial and anti-coagulation properties and preparing method and application thereof
  • Amphiphilic biochar compound with anti-bacterial and anti-coagulation properties and preparing method and application thereof
  • Amphiphilic biochar compound with anti-bacterial and anti-coagulation properties and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Preparation of amphiphilic carbon materials (ACPs): Weigh 50.0 g of brewer’s yeast cells, add 200 mL of deionized water to disperse them evenly, let stand at room temperature for 10 min, remove impurities and floating matter on the surface of the liquid, and filter out the upper layer The dispersion was centrifuged at 8000rpm for 3min, then the supernatant was discarded, and acetone was added to the sediment in the lower layer, and then fully stirred with a glass rod until it was uniformly dispersed, then fully stirred with a glass rod until it was uniformly dispersed, and then placed on a shaker Shake for 20 minutes, centrifuge again and add acetone to evenly disperse and repeat the above operation twice to remove the contents of yeast cells; then wash with deionized water three times to remove the residual acetone solvent. Finally, the precipitate was added to the previously prepared 2% glutaraldehyde-phosphate buffer solution and dispersed evenly, and finally pour...

Embodiment 2

[0062] Example 2 Preparation of TPU / ACPs-Ag / ACPs-Hep Antibacterial Silicone Rubber Catheter

[0063] 1. Preparation of antibacterial silicone rubber catheter

[0064] Weigh 25 mg of ACPs-Ag and ACPs-Hep amphiphilic bio-carbon particles, add them to 5 g of silicone rubber liquid at a mass fraction of 1:100, and mix well. Afterwards, a novel antibacterial catheter is made according to the preparation process of a conventional catheter.

[0065] 2. To verify the antibacterial and anticoagulant properties of ACPs-Ag / ACPs-Hep antibacterial silicone rubber catheter. Antibacterial results such as Figure 14 , ACPs-Ag / ACPs-Hep antibacterial silicone rubber catheter has good antibacterial effect on Staphylococcus aureus, Escherichia coli, Candida albicans and drug-resistant Staphylococcus aureus; the anticoagulant results are as follows Figure 15 , ACPs-Ag / ACPs-Hep antibacterial silicone rubber catheter has strong anti-platelet adhesion.

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PUM

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Abstract

The invention discloses an amphiphilic biochar compound membrane with anti-bacterial and anti-coagulation properties and a preparing method and application thereof. An amphiphilic biochar material formodifying heparin and an amphiphilic biochar material for loading nano-silver are prepared by means of a covalent coupling method and an electrostatic adsorption method respectively and uniformly doped in hydrophobic resin to prepare the compound membrane with the anti-bacterial and anti-coagulation properties. The compound membrane has the broad-spectrum anti-bacterial property and anti-platelet-adhesion property. Therefore, the compound membrane has a strong inhibition effect on both gram-positive bacteria and gram-negative bacteria, and a strong inhibition effect on platelet adhesion, andhas a wide application prospect in the field of infection relevant to medical catheters. The invention discloses the preparing method of the compound membrane.

Description

technical field [0001] The invention relates to an antibacterial and anticoagulant amphiphilic biological carbon complex. Background technique [0002] Bacterial infection and thrombosis are the main causes of medical catheter-related diseases. The adhesion of bacteria and platelets in the catheter can easily form biofilm and thrombus, which greatly increases the incidence of catheter-related diseases. In order to solve the above problems, the traditional method is generally to coat the urinary catheter with antibacterial agent or anticoagulant by dipping method, and use the antibacterial effect of antibacterial agent or anticoagulant effect of anticoagulant to realize the function of antibacterial or antithrombotic . Although the coated urinary catheter has the effect of antithrombotic or antibacterial infection, the dipping method still has shortcomings such as short action time and inconvenient use. How to achieve effective anti-bacterial infection / thrombosis through a ...

Claims

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Application Information

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IPC IPC(8): A61L29/02A61L29/04A61L29/16A61L29/06A61L29/14A61L31/02A61L31/04A61L31/16A61L31/14A61L31/06A61L33/02A61L33/10A61L33/00A61L33/06C01B32/05
CPCA61L29/02A61L29/041A61L29/043A61L29/06A61L29/14A61L29/16A61L31/022A61L31/024A61L31/042A61L31/048A61L31/06A61L31/14A61L31/16A61L33/0005A61L33/0011A61L33/022A61L33/025A61L33/064A61L33/068A61L33/08A61L2300/104A61L2300/236A61L2300/404A61L2300/41A61L2300/42A61L2400/12C01B32/05C08L5/10C08L5/08C08L23/06C08L75/04
Inventor 刘超群刘帅魏志红吴强徐淑霞
Owner 郑州欧姆康生物材料有限公司
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