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Antiinflammatory nasil agent and application thereof to preparation of medicines for relieving inflammation of nasal cavity

A technology for nasal cavity and Chinese medicinal materials, which is applied in the field of anti-inflammatory nasal olfactory and preparation of drugs for relieving nasal cavity inflammation, and can solve the problems of extra stimulation of nasal mucosa, administration, inconvenience and the like.

Inactive Publication Date: 2019-11-19
钱红梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, oral and nasal drops are essentially gastrointestinal absorption or nasal mucosal absorption of the overall active ingredients of traditional Chinese medicine, requiring liquid or powder to contact the nasal mucosa, which leads to additional irritation to the nasal mucosa or inconvenient administration

Method used

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  • Antiinflammatory nasil agent and application thereof to preparation of medicines for relieving inflammation of nasal cavity
  • Antiinflammatory nasil agent and application thereof to preparation of medicines for relieving inflammation of nasal cavity
  • Antiinflammatory nasil agent and application thereof to preparation of medicines for relieving inflammation of nasal cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 The anti-inflammatory effect of nose smell agent

[0038] Prepare the following volatile oils:

[0039] Volatile oil 1: Chuanxiong 100g, Asarum 60g, Angelica dahurica 100g, Xanthium 100g, Magnolias 100g, Chrysanthemum 200g.

[0040] Volatile oil 2: 60g Atractylodes macrocephala, 60g Fangfeng, 100g Chuanxiong, 60g Asarum, 100g Angelica dahurica, 100g cocklebur, 100g magnolia, 200g chrysanthemum.

[0041] Volatile oil 3: Astragalus 720g

[0042] Volatile oil 4: Astragalus 60g, Chuanxiong 100g, Asarum 60g, Angelica dahurica 100g, Xanthium 100g, Magnolias 100g, Chrysanthemum 200g.

[0043] Volatile oil 5: Astragalus 60g, Atractylodes macrocephala 60g, Fangfeng 60g, Chuanxiong 100g, Asarum 60g, Angelica dahurica 100g, Xanthium 100g, Magnolia 100g, Chrysanthemum 200g.

[0044] The above formula weighs the Chinese medicinal materials by weight, crushes the Chinese medicinal materials and passes through a No. 4 sieve, and mixes the obtained powder evenly; adds 10 t...

Embodiment 2

[0052] Example 2 The improvement effect of nasal olfactory agent on gas stimulation-induced rhinitis

[0053] Prepare the following volatile oils:

[0054] Astragalus 240g, Chuanxiong 400g, Asarum 240g, Angelica dahurica 400g, Xanthium 400g, Magnolia 400g, Chrysanthemum 800g. Weigh the Chinese medicinal materials by weight, crush the Chinese medicinal materials and pass through a No. 4 sieve, and mix the obtained powder evenly; add 10 times the weight of water to the obtained Chinese medicinal material powder, steam distillation and extraction at 80°C for 5 hours, and collect and extract the volatile oil.

[0055] Twelve SPF rats, male, weighing 200-220 g, were randomly divided into 2 groups, 6 rats / group.

[0056] 12 rats were placed in a closed box with ventilation holes on the top, the length, width and height were 40 cm respectively. Sodium sulfite and sulfuric acid were used to generate sulfur dioxide, and the concentration of sulfur dioxide in the closed box exceeded 2%...

Embodiment 3 7

[0065] Example 3 Qiwei nasal smell agent powder

[0066] Qiwei nasal smell agent powder is made of Qiwei Chinese medicinal materials as raw materials.

[0067] Formula 1 (720g): Astragalus 60g, Chuanxiong 100g, Asarum 60g, Angelica dahurica 100g, Xanthium 100g, Magnolia 100g, Chrysanthemum 200g.

[0068] Formula 2 (720g): Astragalus 70g, Chuanxiong 90g, Asarum 60g, Angelica dahurica 90g, Xanthium 120g, Magnolia 90g, Chrysanthemum 200g.

[0069] The two formulations were prepared separately and distributed in bottles with different labels to avoid confusion.

[0070] Preparation of each recipe:

[0071] Weigh the Chinese medicinal materials by weight, crush the Chinese medicinal materials through a 100-mesh sieve respectively; mix the obtained Chinese medicinal material powders evenly, divide them into bottles, 144 g per bottle, and seal them for storage.

[0072] When using, use 1 bottle every 1-3 days, open the cap, attach gauze to the mouth of the bottle, put it near the ...

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Abstract

The invention belongs to the field of natural medicines, and particularly relates to an antiinflammatory nasil agent and an application thereof to preparation of medicines for relieving inflammation of a nasal cavity. The antiinflammatory nasil agent is prepared by using astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao / astragalus membranaceus (Fisch.) Bge. roots, ligusticum chuanxiong roots, asarum heterotropoides Fr. Schmidt var. mandshur-icum (Maxim.) Kitag. / asarum sieboldii Miq. var. seoulense Nakai / asarum sieboldii Miq. herbs, angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook.f. / angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan roots, xanthium sibiricum Patr. fruits, magnolia biondii Pamp. / magnolia denudata Desr. / magnolia sprengeri Pamp. buds, and chrysanthemum morifolium Ramat. inflorescences as raw materials, and atractylodes macrocephala koidz. rhizomes and saposhnikovia divaricata (Turcz.) Schischk roots can be added. During preparation of the antiinflammatory nasil agent, a traditional Chinese medicine material powder mixture is placed in a bottled container or a traditional Chinese medicine material volatile oil extract is placed in a bottled container. While in use of the antiinflammatory nasil agent, a bottle cap is opened, and volatile ingredients are released and inhaled and heard into the nasal cavity so asto relieve inflammatory reactions of respiratory tracts of the nasal cavity, the trachea, the bronchus, the lungs and the like. According to the antiinflammatory nasil agent, medicinal materials volatile oil is used as an active site, the antiinflammatory nasil agent has relieving effects on inflammation and inflammation of chronic rhinitis induced by chemical stimuluses, is convenient to processand use, and is suitable for large-scale production and application by common people, and comprehensive utilization of traditional Chinese medicine materials is facilitated.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to an anti-inflammatory nasal olfactory agent and the preparation of a medicine for alleviating nasal cavity inflammation. Background technique [0002] Inflammation is a common condition in the human body. When the human body is subjected to external stimuli, such as surgery, chemical stimulation and other changes, inflammatory reactions will occur, including gastritis, hepatitis, conjunctivitis, rhinitis, tracheitis, bronchitis, pneumonia and so on. Such inflammatory responses are generally controlled with systemic or local anti-inflammatory drugs. Commonly used anti-inflammatory drugs include glucocorticoids, non-steroidal anti-inflammatory drugs and so on. There are also a large number of anti-inflammatory components in traditional Chinese medicine, and some traditional Chinese medicine extracts or single natural compounds have been found to have anti-inflammatory ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61P11/02A61P29/00
CPCA61K9/0014A61K9/0043A61K9/007A61K36/232A61K36/236A61K36/268A61K36/28A61K36/287A61K36/481A61K36/575A61K2236/331A61P11/02A61P29/00A61K2300/00
Inventor 俞鑫吕律钱定安张蕴菁
Owner 钱红梅
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