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Preparation method of high-strength injectable polyphase calcium phosphate based bone cement

A technology of phase calcium phosphate and bone cement, applied in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of no osteoinductive activity, monomer toxicity, poor biological activity, etc., to promote osteoinductive ability, accelerate bone The effect of regeneration, repair and improvement of biological activity

Active Publication Date: 2019-11-26
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the most commonly used bone repair material is polymethylmethacrylate (PMMA), because of its good biocompatibility, high mechanical properties and strong operability, it can be used in balloon expansion of vertebral bodies. Balloon kyphoplasty (BKP) and vertebroplasty (Vertebroplasty, VP) are widely used, however, poor biological activity, large heat release after monomer polymerization can lead to thermal necrosis of tissue in the surgical area and unpolymerized The disadvantages of monomers such as toxicity limit the further application of PMMA in clinical
Compared with PMMA, calcium phosphate cement (CPC) does not have a large amount of exothermic phenomenon after the reaction of PMMA, and it has good biocompatibility, bioactivity and osteoconduction activity, so it has become a popular bone cement. Restorative materials, however CPC, like PMMA, does not have osteoinductive activity
In addition, the mechanical properties of CPC are poor, which limits the application of CPC in load-bearing parts.

Method used

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  • Preparation method of high-strength injectable polyphase calcium phosphate based bone cement
  • Preparation method of high-strength injectable polyphase calcium phosphate based bone cement
  • Preparation method of high-strength injectable polyphase calcium phosphate based bone cement

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A preparation method of a high-strength injectable heterogeneous calcium phosphate-based bone cement, comprising the steps of:

[0025] 1) Mix α-tricalcium phosphate powder, calcium sulfate hemihydrate powder and bioactive glass powder as raw materials; calcium sulfate hemihydrate is obtained by heating calcium sulfate dihydrate at 100-150°C for 12-24 hours;

[0026] The preparation method of bioactive glass is as follows: first, take 1.8g of calcium nitrate tetrahydrate and join in 5 ml of ethyl orthosilicate, then, add 16 ml of deionized water and absolute ethanol with a molar ratio of 1:1 The mixed solution of, finally, adds 6g glacial acetic acid wherein again. The sol was reacted by stirring, and the prepared sol was dried in an oven at 60° C. for 12-24 hours to obtain a xerogel. The dry gel is placed in a muffle furnace, heated to 550-750° C. at a heating rate of 5-10° C. / min, kept for 2 hours, and cooled naturally to obtain the bioactive glass.

[0027] Among t...

Embodiment 2

[0033] A preparation method of a high-strength injectable heterogeneous calcium phosphate-based bone cement, comprising the steps of:

[0034] 1) Premix α-tricalcium phosphate powder, calcium sulfate hemihydrate powder and bioactive glass powder as raw materials; in the raw materials, the mass fractions of α-tricalcium phosphate, calcium sulfate hemihydrate and bioactive glass are 76wt %, 19wt% and 5wt%;

[0035] 2) Put the pre-mixed raw materials together with agate medium balls and absolute ethanol into a ball mill for ball milling; make the raw materials fully mixed evenly, and make the particle size of the raw materials uniform through ball milling; during ball milling, the raw materials, agate medium balls and no The water-ethanol mass ratio is 1: 30: 12, ball milling for 8-12 hours at a speed of 400-900 rpm.

[0036] 3) Take out the ball-milled wet material containing absolute ethanol, place it in an oven at 60-100°C and dry it for 5-10 hours to obtain bone cement powde...

Embodiment 3

[0040] A preparation method of a high-strength injectable heterogeneous calcium phosphate-based bone cement, comprising the steps of:

[0041] 1) Premix α-tricalcium phosphate powder, calcium sulfate hemihydrate powder and bioactive glass powder as raw materials; in the raw materials, the mass fractions of α-tricalcium phosphate, calcium sulfate hemihydrate and bioactive glass are 76wt %, 19wt% and 5wt%;

[0042] 2) Put the mixed raw materials together with agate medium balls and absolute ethanol into a ball mill for ball milling; mix the raw materials evenly, and make the particle size of the raw materials uniform through ball milling; during ball milling, the raw materials, agate medium balls and anhydrous Ethanol was ball milled for 8-12 hours at a mass ratio of 1: 30: 12 at a speed of 400-600 rpm.

[0043] 3) Take out the ball-milled wet material containing absolute ethanol, place it in an oven at 60-100°C and dry it for 5-10 hours to obtain bone cement powder;

[0044] ...

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Abstract

The invention belongs to the field of bone restoration medical material, and discloses a preparation method of a high-strength injectable polyphase calcium phosphate based bone cement. The high-strength injectable polyphase calcium phosphate based bone cement is prepared through uniform blending and solidification of a bone cement power with a solidification liquid containing meglumine, wherein the bone cement powder is prepared through uniform mixing of alpha-tricalcium phosphate powder, calcium sulfate hemihydrate powder, biologically active glass, and polyglutamic acid at a certain ratio. The obtained bone cement material possesses excellent injectable performance, and collapse resistance; after 7 days of solidification at 37 DEG C, the mechanical compression strength reaches 113.68+ / 7.11Mpa; in decomposition process, Ca<2+> and PO4<3-> are released, and Si ions capable of promoting bone induction are released at the same time, so that the high-strength injectable polyphase calciumphosphate based bone cement is suitable to be taken as a centrum filter in PVP / PKP minimally invasive surgery. The preparation method is simple in technology; product comprehensive performance is excellent; and large scale production application can be realized.

Description

technical field [0001] The invention relates to the technical field of bone repair medical materials, in particular to a preparation method of high-strength injectable multiphase calcium phosphate-based bone cement. Background technique [0002] With the gradual improvement and improvement of living conditions and quality of life, human life expectancy is generally extended, and the proportion of aging population is increasing. At the same time, the incidence of many diseases is also increased. The vertebral body caused by osteoporosis Fractures or bone defects are the most common diseases of the elderly population. Although human bones have certain self-repair and regeneration functions, it is not feasible to heal bone defects solely relying on bone self-repair functions. Therefore, there is a need for implantation of bone repair materials to heal and repair bone defects. Among them, the most commonly used bone repair material is polymethylmethacrylate (PMMA), because of i...

Claims

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Application Information

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IPC IPC(8): C04B28/34A61L27/12A61L27/10A61L27/18A61L27/50A61L27/58
CPCA61L27/10A61L27/12A61L27/18A61L27/50A61L27/58A61L2400/06A61L2430/02C04B28/344C04B2111/00836C04B2201/52C08L77/04C04B22/143C04B14/22C04B24/28C04B24/122
Inventor 高春霞濮志文朱沛志
Owner YANGZHOU UNIV
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