Preparation method of high-strength injectable polyphase calcium phosphate based bone cement

A technology of phase calcium phosphate and bone cement, applied in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of no osteoinductive activity, monomer toxicity, poor biological activity, etc., to promote osteoinductive ability, accelerate bone The effect of regeneration, repair and improvement of biological activity
CN110498664AActive Publication Date: 2019-11-26YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2019-11-26

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Abstract

The invention belongs to the field of bone restoration medical material, and discloses a preparation method of a high-strength injectable polyphase calcium phosphate based bone cement. The high-strength injectable polyphase calcium phosphate based bone cement is prepared through uniform blending and solidification of a bone cement power with a solidification liquid containing meglumine, wherein the bone cement powder is prepared through uniform mixing of alpha-tricalcium phosphate powder, calcium sulfate hemihydrate powder, biologically active glass, and polyglutamic acid at a certain ratio. The obtained bone cement material possesses excellent injectable performance, and collapse resistance; after 7 days of solidification at 37 DEG C, the mechanical compression strength reaches 113.68+ / 7.11Mpa; in decomposition process, Ca<2+> and PO4<3-> are released, and Si ions capable of promoting bone induction are released at the same time, so that the high-strength injectable polyphase calciumphosphate based bone cement is suitable to be taken as a centrum filter in PVP / PKP minimally invasive surgery. The preparation method is simple in technology; product comprehensive performance is excellent; and large scale production application can be realized.
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Description

technical field

[0001] The invention relates to the technical field of bone repair medical materials, in particular to a preparation method of high-strength injectable multiphase calcium phosphate-based bone cement. Background technique

[0002] With the gradual improvement and improvement of living conditions and quality of life, human life expectancy is generally extended, and the proportion of aging population is increasing. At the same time, the incidence of many diseases is also increased. The vertebral body caused by osteoporosis Fractures or bone defects are the most common diseases of the elderly population. Although human bones have certain self-repair and regeneration functions, it is not feasible to heal bone defects solely relying on bone self-repair functions. Therefore, there is a need for implantation of bone repair materials to heal and repair bone defects. Among them, the most commonly used bone repair material is polymethylmethacrylate (PMMA), because of i...

Claims

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