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Graphite paper-based molecularly imprinted sensor modified by Fe3O4 and its preparation method and application

A molecular imprinting and graphite paper technology, applied in the fields of iron oxide/iron hydroxide, ferrous oxide, chemical analysis using catalysis, etc., can solve the problems of complicated operation and expensive electrode materials, and achieve simple preparation, High sensitivity and stable performance

Active Publication Date: 2022-03-15
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently reported AE detection methods include high performance liquid chromatography, polarography, thin layer chromatography, capillary electrophoresis, electrochemical methods, etc. However, these methods often have problems such as expensive electrode materials and complicated operations.

Method used

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  • Graphite paper-based molecularly imprinted sensor modified by Fe3O4 and its preparation method and application
  • Graphite paper-based molecularly imprinted sensor modified by Fe3O4 and its preparation method and application
  • Graphite paper-based molecularly imprinted sensor modified by Fe3O4 and its preparation method and application

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Experimental program
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preparation example Construction

[0027] In the above Fe 3 o 4 In the preparation method of / EGP, the specific type of each material can be selected in a wide range, but considering the cost, preferably, the iron source is selected from FeCl 3 ·6H 2 O, FeCl 3 At least one of them; the organic solvent is ethylene glycol; the salt is sodium acetate.

[0028] In the above Fe 3 o 4 In the preparation method of / EGP, the consumption of each material can be selected in a wide range, but in order to further improve the MIP / Fe that makes 3 o 4 / EGP sensitivity and anti-interference, preferably, based on 0.5cm wide and 6cm long EGP, the amount of iron source is 1-1.5mmol, the amount of organic solvent is 10-30mL, and the amount of salt is 10-15mmol .

[0029] In the above Fe 3 o 4 In the preparation method of / EGP, the condition of contact reaction can be selected in a wide range, but in order to further improve the MIP / Fe that makes 3 o 4 / EGP sensitivity and anti-interference, preferably, the contact rea...

preparation example 1

[0039] 1) Pretreatment of graphite paper electrodes

[0040] Use a knife and a scale to cut the A4-sized graphite paper into a rectangular paper strip with a width of 0.5 cm and a length of 6 cm. Dip the cut graphite paper into a beaker filled with ethanol, soak and clean for 15 minutes, take it out to dry, and peel off both sides with adhesive tape when using.

[0041] 2) Preparation of Fe 3 o 4 Modified graphite paper electrodes (Fe 3 o 4 / EGP)

[0042] FeCl 3 ·6H 2 O (1.25mmol) was added to 20mL of ethylene glycol, and the FeCl 3 ·6H 2 O is completely dissolved. Then NaAc (12 mmol) was added thereto, the mixture was vigorously stirred for 30 min, and then transferred to a 40 mL autoclave, and the treated graphite paper substrate electrode was put into the autoclave, and reacted at 200 °C for 8 h. Naturally cool to 25°C, take out the electrode, rinse with distilled water and ethanol three times alternately, then dry the electrode at 60°C for 12h

Embodiment 1

[0044] Fix Fe with tape 3 o 4 The active area of ​​ / EGP is 0.5×0.5cm 2 ; the Fe 3 o 4 / EGP electrode immersed in 5mL mixed solution (containing 40mmol / L pyrrole, 3.3mmol / L aloe-emodin, 0.1mol / L lithium perchlorate; PBS buffer solution with pH 5.0 as the base solution), using cyclic voltammetry Electropolymerization was carried out using the method (the polymerization potential is -0.6 ~ 0.8V, the scanning rate is 0.05V / s, and the number of polymerization circles is 20 circles).

[0045] Next, put the above modified electrode into 5mL 0.5mol / L H 2 SO 4 In the solution, cyclic voltammetry is used for electrochemical elution (potential is -0.4 to 1.6V, scan rate is 0.05V / s, and the number of cycles is 20), that is, MIP / Fe 3 o 4 / EGP.

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Abstract

The invention discloses a graphite paper-based molecularly imprinted sensor modified with ferric oxide and its preparation method and application. The preparation method is as follows: Fe 3 o 4 Modified graphite paper electrode Fe 3 o 4 / EGP is placed in a mixed solution for electropolymerization, followed by electrochemical elution to obtain Fe 3 o 4 Modified graphite paper-based molecularly imprinted sensor MIP / Fe 3 o 4 / EGP; the graphite paper-based molecularly imprinted sensor can quantitatively and sensitively detect AE using ultraviolet spectrophotometry and has good anti-interference performance, so that it can be applied to AE detection, and the preparation method is simple and easy to operate The advantages.

Description

technical field [0001] The invention relates to an imprinted sensor, in particular to a graphite paper-based molecular imprinted sensor modified with ferric oxide and its preparation method and application. Background technique [0002] Tumor is the canceration of cells induced by various factors, and has become one of the major diseases that endanger human health. Aloe-emodin (AE) is an anthraquinone traditional Chinese medicine monomer with a wide range of pharmacological effects. It is widely found in aloe, cassia seed and rhubarb, and has bactericidal and anticancer effects. Therefore, sensitive and effective detection of AE is of great significance to human health. [0003] The reported AE detection methods include high-performance liquid chromatography, polarography, thin-layer chromatography, capillary electrophoresis, and electrochemical methods. However, these methods often have problems such as expensive electrode materials and complicated operations. Contents o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/33G01N31/10C01G49/08
CPCG01N21/33G01N31/10C01G49/08
Inventor 阚显文汪萌
Owner ANHUI NORMAL UNIV