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Amphipathic random copolymer with disulfide bond and preparation method and application of amphipathic random copolymer

A random copolymer, amphiphilic technology, applied in the field of polymer materials, to achieve the effect of excellent chelating function

Inactive Publication Date: 2019-12-20
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art, provide a kind of amphiphilic random copolymer containing disulfide bond, preparation method and application thereof, solve the problem of amphiphilicity of nanocrystalline materials in the above-mentioned background technology

Method used

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  • Amphipathic random copolymer with disulfide bond and preparation method and application of amphipathic random copolymer
  • Amphipathic random copolymer with disulfide bond and preparation method and application of amphipathic random copolymer
  • Amphipathic random copolymer with disulfide bond and preparation method and application of amphipathic random copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Preparation of functional monomer MALA

[0037] Add lipoic acid (4g, 19mmol) and hydroxyethyl methacrylate (2.5g, 19mmol) into a 100mL single-necked bottle, measure 60mL of dichloromethane, and stir to dissolve in an ice bath. Then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (7.4g, 36.8mmoL), 4-dimethylaminopyridine (2.4g, 8.2mmoL), and react at room temperature 18h. After the reaction, the above mixed solution was transferred to a 250mL separatory funnel, and extracted according to the following steps: a. 1mol / L hydrochloric acid washing / extracting sample (200mL, divided into 6 times); b. saturated NaHCO 3 Wash / extract sample with solution (150mL, divided into 3 times); c. Wash with saturated NaCl solution / extract sample (150mL, divided into 3 times) until the solution is clear. Then, the solvent was removed by rotary evaporation, and dried in vacuum for about 2 hours to obtain a light yellow transparent liquid.

[0038] (2) Preparation of hy...

Embodiment 2～4

[0045] The process conditions are the same as in Example 1, but in step 3) in the step of preparing the amphiphilic polymer, the ratio of MAPEG containing adjacent hydrophilic segments and hydrophobic monomer MAHA is changed.

[0046] Table 1

[0047]

[0048]

Embodiment 5

[0050] (1) Using the classic liquid phase reduction method, slowly add chloroauric acid solution in the sodium citrate solution to obtain gold nanoparticles with uniform particle size;

[0051] (2) The amphiphilic random copolymer P (MAPEG-co-MALA-co-MAHA) described in Example 1 was dissolved in tetrahydrofuran, and irradiated with ultraviolet light for 0.5-3 hours. At room temperature, an aqueous solution of gold nanoparticles was added and stirred overnight. Open the door, and after THF is completely volatilized, refrigerate and centrifuge to obtain Au@P(MAPEG-co-MALA-co-MAHA) nanoparticles. The ratio of P(MAPEG-co-MALA-co-MAHA) to THF is 1~3g:1L.

[0052] Such as image 3 , the absorption peak position of the gold nanoparticles prepared in this example is at 525nm, the absorption peak position of the amphiphilic random copolymer is at 250nm, and the polymer@Au nanoparticles have absorption peaks at 250nm and 525nm, proving that, The successful synthesis of the Au@P(MAPEG...

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Abstract

The invention discloses an amphipathic random copolymer with a disulfide bond and a preparation method and application of the amphipathic random copolymer. The preparation method comprises the following steps: firstly, synthesizing monomers with a disulfide bond and an aldehyde group respectively, performing a double-bond addition reaction of the monomers, and performing RAFT (reversible additionfragmentation chain) polymerization so as to synthesize the amphipathic random copolymer. Because of existence of the disulfide bond, the amphipathic random copolymer disclosed by the invention has good chelation with a nano crystal, and in addition, because of hydrophilic / hydrophobic monomers, the amphipathic random copolymer has amphipathicity, thus has good biocompatibility and has potential application in biological medical application.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to an amphiphilic copolymer containing a disulfide bond, a preparation method and an application thereof. Background technique [0002] In recent years, nanocrystalline materials have shown great application potential in many biological aspects such as imaging, sensing, and diagnosis, among which water-soluble nanocrystals are one of the most widely studied nanocrystalline materials. At present, the two-step synthesis method of first synthesizing high-quality oil-soluble nanocrystals and then phase-transferring to the aqueous phase is the most effective method for preparing water-soluble nanocrystals. For the process of phase transfer, the method of ligand exchange is often used to realize the strong complexation force between elements such as Zn, Cd, etc. on the specific surface of nanocrystals and mercapto groups, and replace organic ligands with mercapto reagents to m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/06C08F220/38C08F220/30B82Y40/00B82Y30/00
CPCB82Y30/00B82Y40/00C08F283/065C08F2438/03
Inventor 曾碧榕王潇戴李宗朱继红吴海洋沈洪周瑞瑞陈国荣罗伟昂
Owner XIAMEN UNIV
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