Application of gentamicin to preparation of drugs for treatment of cholestasis

A technology for cholestasis and gentamicin, which is applied in the field of medicine and can solve the problems that gentamicin has not been reported.

Inactive Publication Date: 2019-12-27
THE FIRST HOSPITAL OF LANZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of gentamicin to preparation of drugs for treatment of cholestasis
  • Application of gentamicin to preparation of drugs for treatment of cholestasis
  • Application of gentamicin to preparation of drugs for treatment of cholestasis

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Embodiment 1

[0022] 1. Materials and methods

[0023] (1) Experimental equipment

[0024] Liquid-mass spectrometry (Agilent), optical microscope (GBS, Germany), analytical balance (Beijing Sartorius), electronic balance (Ohaus International Trade (Shanghai) Co., Ltd.), tissue cell disruptor (Baipu Nuo ( Beijing) Science and Trade Co., Ltd.), high-speed centrifuge (Sigma-Aldrich Company), automatic biochemical analyzer (Roche, Switzerland), vortex mixer (Shanghai Medical University Instrument Factory).

[0025] (2) Experimental reagents

[0026] Ethinyl estradiol (purity 98%) (Beijing Bailingwei Technology Co., Ltd.), BAs standard used in the experiment includes cholic acid (Cholic acid, CA), chenodeoxycholic acid (Chenodeoxycholic acid, CDCA), deoxycholic acid (Deoxycholic acid , DCA), lithocholic acid (Lithocholic acid, LCA), hyodesoxycholic acid (Hyodesoxycholic acid, HDCA), ursodeoxycholic acid (Ursodeoxycholic acid, UDCA), muricholic acid (β-muricholic acid, β-MCA) Its glycine-bindi...

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Abstract

The invention belongs to the field of medicines, and relates to application of gentamicin to preparation of drugs for treatment of cholestasis. The oral gentamicin can significantly decrease the concentration of cholate in blood, decrease the concentration of toxic cholate in liver and ileum tissues and inhibit hepatic pathological changes.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of gentamicin in the preparation of medicines for treating cholestasis. Background technique [0002] Cholestasis is a liver disease caused by bile secretion or excretion disorders caused by various reasons, so that bile cannot flow into the intestinal tract normally and instead flows back into the blood circulation. The clinical manifestations caused by cholestasis include elevated levels of bile salts, alkaline phosphatase and glutamyl transpeptidase, and impaired liver function. Although its pathogenesis has been deeply analyzed at the molecular level, so far, there is no specific treatment for cholestatic liver disease. According to reports in the literature, reducing the level of bile salts is the key to treatment, which can reduce liver damage and relieve clinical symptoms (Chen Xiaoqing , Yingchun, Etiology and Treatment of Intrahepatic Cholestatic Live...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61P1/16
CPCA61K31/7036A61P1/16
Inventor 武新安王欢马彦荣辛明彦
Owner THE FIRST HOSPITAL OF LANZHOU UNIV
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