Production method and application of attapulgite-dimercaptosuccinic acid-modified ferroferric oxide nanometer compound particles

A technology of dimercaptosuccinic acid and ferroferric oxide, applied in the field of attapulgite, can solve problems such as unfavorable sustainable development, difficulty in recycling, unfriendly environment, etc., and achieve shortened preparation time, improved production efficiency, and good paramagnetism Effect

Pending Publication Date: 2019-12-27
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem to be solved: The technical problem to be solved in this application is that the preparation process of attapulgite in the existing medical field is complex, and toxic and harmful components are likely to remain in the preparation process, difficult to recycle, unfriendly to the environment, and unfavorable for sustainable development. Provided is a preparation method of attapulgite-dimercaptosuccinic acid modified iron ferric oxide nanocomposite particles. The whole process of the preparation method uses relatively safe reagents, the preparation process is safe and non-toxic, and the operability is strong. The obtained drug carrier attapulgite-dimercaptosuccinic acid modified Fe3O4 nanocomposite particles has low toxicity and side effects, and can carry drugs to the lesion smoothly under the action of an external magnetic field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing attapulgite-dimercaptosuccinic acid modified ferric oxide nanocomposite particles, comprising the following steps:

[0032] Step 1, purification of attapulgite: take an appropriate amount of attapulgite original soil, add purified water equivalent to 5 times the weight of attapulgite original soil and α-cyclodextrin equivalent to 0.2 times the weight of attapulgite original soil, and ultrasonically disperse for 2 hours , the ultrasonic dispersion temperature is 60°C, and the ultrasonic frequency is 20kHz;

[0033] After the ultrasonic wave is finished, take the upper layer liquid, after spray drying, put the dry powder into the vacuum electric furnace, the temperature of the vacuum electric furnace is 300°C; take it out after high-temperature calcination for 10 hours, and after cooling down to room temperature, finely grind, package, and reserve to obtain the purified attapulgite earth;

[0034] The fine grinding is ball milling;

[0035] The ba...

Embodiment 2

[0052] A method for preparing attapulgite-dimercaptosuccinic acid modified ferric oxide nanocomposite particles, comprising the following steps:

[0053] Step 1, purification of attapulgite: take an appropriate amount of attapulgite original soil, add purified water equivalent to 20 times the weight of attapulgite original soil and α-cyclodextrin equivalent to 0.5 times the weight of attapulgite original soil, and ultrasonically disperse for 2.5 h, the ultrasonic dispersion temperature is 70°C, and the ultrasonic frequency is 40kHz;

[0054] After the ultrasonic wave is completed, take the upper layer liquid, after spray drying, put the dry powder into the vacuum electric furnace, the temperature of the vacuum electric furnace is 350°C; take it out after high-temperature calcination for 16 hours, and after cooling down to room temperature, finely grind, package, and reserve to obtain the purified attapulgite earth;

[0055] The fine grinding is ball milling;

[0056] The bal...

Embodiment 3

[0073] The difference between this example and Example 1 is that the specific steps of temperature program are 0~10min, keep ultrasonic at 45°C; 10~30min, heat up the ultrasonic instrument to 70°C; , the ultrasonic instrument is heated to 90°C; 110~140min, maintain 90°C for ultrasonic.

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Abstract

The invention discloses a production method and application of attapulgite-dimercaptosuccinic acid-modified ferroferric oxide nanometer compound particles. The production method comprises the following steps: (1) purifying attapulgite; (2) producing oil-soluble ferroferric oxide nanometer particles; (3) obtaining the oil-soluble ferroferric oxide nanometer particles; (4) producing ferroferric oxide nanometer particles modified by dimercaptosuccinic acid; and (5) producing the attapulgite-dimercaptosuccinic acid-modified ferroferric oxide nanometer compound particles. According to the providedproduction method and application of the attapulgite-dimercaptosuccinic acid-modified ferroferric oxide nanometer compound particles, safe agents are used in the whole production process, the production process is safe and non-toxic, the operability is high, and the produced medicine carrier attapulgite-dimercaptosuccinic acid-modified ferroferric oxide nanometer compound particles have small toxic and side effects, and can reach a focus smoothly under the action of an external magnetic field while carrying a medicine.

Description

technical field [0001] The invention relates to a preparation method and application of attapulgite-dimercaptosuccinic acid modified ferric oxide nanocomposite particles, belonging to the technical field of attapulgite. Background technique [0002] Attapulgite (ATP), also known as palygorskite (Palygorskite, Pal), is an inorganic non-metallic clay mineral with a layered chain structure containing magnesium-rich aluminum silicate, and its theoretical chemical formula is MgAl 5 Si 8 o 20 (OH) 2 (OH 2 ) 4 4H 2 O. The unit cell in its crystal structure is composed of two layers of silicon-oxygen tetrahedron sandwiching a layer of magnesium (aluminum)-oxygen (hydroxyl) octahedron, which belongs to the 2:1 type layered chain silicate. [0003] Because attapulgite has a large specific surface area and many nano-scale pores, its adsorption performance and thermal stability are excellent, and it is widely used in petroleum, chemical industry, construction, papermaking, sewa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/54A61K47/52B82Y5/00B82Y30/00
CPCA61K47/6923A61K47/52A61K47/542B82Y30/00B82Y5/00
Inventor 胡涛刘彦芳姜孝武茆平蔡鹏郭探云山游庆宏
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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