Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical double-shell porous structure hollow nanospheres and preparation method thereof

A hollow nano-porous structure technology, applied in the field of biomedical magnetic materials, can solve unseen problems, achieve uniform size, change relaxation rate and relaxation time, and light weight

Active Publication Date: 2021-06-18
CENT SOUTH UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No relevant research and reports have been seen so far

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical double-shell porous structure hollow nanospheres and preparation method thereof
  • Medical double-shell porous structure hollow nanospheres and preparation method thereof
  • Medical double-shell porous structure hollow nanospheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Preparation of phenolic resin microspheres. Measure 200ml of deionized water, 10ml of absolute ethanol and 1ml of ammonia water into a dry 500ml three-neck flask and mix, add 1g of resorcinol, slowly add 2ml of formaldehyde solution, and stir in an oil bath at 30°C for 10h. After the reaction, the mixed solution was transferred to a high-pressure reactor, and placed in a vacuum drying oven at 80° C. for hydrothermal reaction for 22 hours for aging. Then the solid and liquid were separated, and the solid was vacuum-dried at 80° C. for 24 hours to obtain phenolic resin (PF) microspheres with a size of about 200 nm.

[0050] (2) Preparation of rare earth ion Ce 3+ Doped Zn(Fe,Ce) 2 o 4 Ferrite precursor solution. According to Zn(Fe,Ce) 2 o 4 Molar ratio, respectively weigh appropriate amount of nitrate, including Zn(NO 3 ) 2 , Fe(NO 3 ) 3 and Ce(NO 3 ) 3 , Put the weighed several nitrates into the beaker, and add an appropriate amount of deionized water at ...

Embodiment 2

[0059] (1) Preparation of phenolic resin microspheres. Measure 300ml of deionized water, 40ml of absolute ethanol and 10ml of ammonia water into a dry 500ml three-necked flask and mix, add 10g of resorcinol, then slowly add 6ml of formaldehyde solution to the mixed solution, and stir in an oil bath at 40°C for 12h. After the reaction, the mixed solution was transferred to a high-pressure reactor, and placed in a vacuum drying oven at 100° C. for hydrothermal reaction for 26 hours for aging. Then the solid and liquid were separated, and the solid was vacuum-dried at 80° C. for 24 hours to obtain phenolic resin (PF) microspheres with a size of about 800 nm.

[0060] (2) Preparation of rare earth ion Ce 3+ Doped Zn(Fe,Ce) 2 o 4 Ferrite precursor solution. According to Zn(Fe,Ce) 2 o 4 Molar ratio, respectively weigh appropriate amount of nitrate, including Zn(NO 3 ) 2 , Fe(NO 3 ) 3 and Ce(NO 3 ) 3 , Put the weighed several nitrates into the beaker, and add an appropria...

Embodiment 3

[0069](1) Preparation of phenolic resin microspheres. Measure 270ml of deionized water, 25ml of absolute ethanol and 5ml of ammonia water into a dry 500mL three-neck flask and mix, add 6g of resorcinol, slowly add 3ml of formaldehyde solution, and stir in an oil bath at 30°C for 12h. After the reaction, the mixed solution was transferred to a high-pressure reactor, and placed in a vacuum oven at 100° C. for hydrothermal reaction for 24 hours for aging. Separation of solid and liquid, take the solid and vacuum dry at 70°C to obtain phenolic resin (PF) microspheres with a size of about 500nm.

[0070] (2) Preparation of rare earth ion Ce 3+ Doped Zn(Fe,Ce) 2 o 4 Ferrite precursor solution. According to Zn(Fe,Ce) 2 o 4 Molar ratio, respectively weigh appropriate amount of nitrate, including Zn(NO 3 ) 2 , Fe(NO 3 ) 3 and Ce(NO 3 ) 3 , Put the weighed several nitrates into the beaker, and add an appropriate amount of deionized water at the same time, fully dissolve in a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A medical hollow nanosphere with a double-shell porous structure and a preparation method thereof, the hollow nanosphere has a double-shell structure, and the inner shell is porous nano-Zn (Fe, Ce) 2 o 4 ferrite, shell made of porous CeO 2 Wrapped on the surface of the inner shell. Its preparation method is based on Zn(Fe,Ce) 2 o 4 Determine the molar ratio of each component to prepare Zn(Fe,Ce) 2 o 4 Ferrite precursor solution, adding it to alcohol and deionized water dispersed with phenolic resin microspheres, adjusting the pH of the system to 9-10 for at least 3 hours, separating the solid from the liquid, washing the solid, vacuum drying, and air Heating to 400~600℃ and keeping it warm to obtain medical Zn(Fe,Ce) 2 o 4 / CeO 2 Hollow nanospheres with porous structure. The porous hollow prepared by the present invention has short relaxation time and good transverse relaxation efficiency, good fluorescence effect, excellent superparamagnetism, large specific surface area, and its cavity and pores can accommodate loaded drugs, High drug loading for efficient drug loading and release.

Description

technical field [0001] The invention discloses a hollow nanosphere with a double-shell porous structure for medical use and a preparation method; in particular, it relates to a medical superparamagnetic Zn(Fe,Ce) 2 o 4 / CeO 2 A hollow nanosphere with a double-shell porous structure and a preparation method thereof. The invention belongs to the technical field of biomedical magnetic materials. Background technique [0002] At present, the incidence of cancer is increasing year by year. The key clinical problems that need to be solved in the treatment of cancer include: accurate in vivo fluorescence imaging of tumors, magnetic resonance imaging (MRI) visualized precise resection, and precise targeted drug delivery chemotherapy for laryngeal squamous cell carcinoma cells. . The current organic fluorescent dyes used in fluorescence imaging have disadvantages such as short fluorescence lifetime of dye molecules, lack of tumor tissue specificity, and poor photochemical stabili...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/02A61K31/704A61P35/00A61K49/00A61K49/18
CPCA61K9/5115A61K31/704A61K49/0002A61K49/0093A61K49/1818A61P35/00
Inventor 李丽娅邓茹心高智葛毅成
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com