Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof

Abstract

The invention discloses an antibody preparation for preventing and treating bovine viral diarrhea. Every 100 g of the preparation is prepared from the following components by weight: 0.01-10.0 g of bovine viral diarrhea antibodies, 15.0-25.0 g of lecithin, 5.0-30.0 g of polyethylene glycol 800, 0.01-2.0 g of beta-sitosterol, 1.0-5.0 g of corilagin, 10.0-20.0 g of tween-20 and the balance of deionized water. Meanwhile, the invention further discloses a preparation method, process operability is high, and production conversion is facilitated. The antibody preparation can prevent the antibodies from being degraded in the rumen after being orally taken, can be fused with intestinal mucosal cells after entering intestinal tracts, releases the antibody, neutralizes viruses on the surface of mucosas and has the characteristic of high bioavailability, and the clinical curative effect is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to an antibody preparation for preventing and treating bovine viral diarrhea and a preparation method thereof. Background technique [0002] Bovine viral diarrhea is caused by bovine viral diarrhea virus infection. The pathogen belongs to the genus Pestivirus in the Flaviviridae family. Cattle of all ages can be infected, and young cattle are most susceptible. The pathological features of the infected cattle showed erosion, inflammation and shedding of intestinal mucosa, watery feces, foul smell, a lot of mucus and air bubbles. Sick cows have elevated body temperature, abdominal pain, decreased feed intake, and indigestion of feed, which seriously affect growth and development, and some cows may even die, and pregnant cows may suffer from miscarriage. Once the cattle farm is infected with this disease, if there is no effective control plan, it will eventual...

AI Technical Summary

Problems solved by technology

Since cattle are ruminants, a large number of microorganisms exist in the rumen environment, and the complex environment easily leads to structural denaturation of antibodies. In addition, rumen fluid contains a large amount of proteases, peptidases, etc., which have a certain degradation effect on antibodies. The antibody preparation is not protected by the carrier, and when it enters the intestinal tract through the rumen after oral administration, most of the antibodies are destroyed, making the actual utilization rate of the drug very low, and ultimately leading to a greatly reduced effect

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