Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof

A bovine viral diarrhea and antibody technology is applied in the direction of antiviral agents, antibodies, and medical preparations with non-active ingredients, etc. It can solve the problems of low utilization rate of drugs, structural denaturation of antibodies, and discounted effects, so as to facilitate the supply of drinking water. medicine, accelerated recovery, and safe use

Active Publication Date: 2020-01-10
信阳市动物疫病预防控制中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since cattle are ruminants, a large number of microorganisms exist in the rumen environment, and the complex environment easily leads to structural denaturation of antibodies. In addition, rumen fluid contains a large amount of proteases, peptidases, etc., which have a certain degradation effect on

Method used

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  • Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof
  • Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof

Examples

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Example Embodiment

[0023] Example 1-11

[0024] In order to make the description concise, the weight composition of the antibody preparations for preventing and treating bovine viral diarrhea described in Examples 1-11 is given in the form of a table below, as shown in Table 1.

[0025] Table 1 The weight composition of each 100g of the antibody preparation of the present invention in Examples 1-11

[0026]

[0027]

[0028] The preparation method of the antibody preparation for preventing and treating bovine viral diarrhea described in embodiment 1-11 includes the following steps:

[0029] (a) After mixing β-sitosterol and tannin evenly, add them to polyethylene glycol 800, stir until dissolved, to obtain system 1;

[0030] (b) Mix the bovine viral diarrhea antibody with lecithin and stir evenly to obtain system 2;

[0031] (c) Mix system 1, system 2 and Tween-20, stir evenly to obtain system 3;

[0032] (d) Heat the system 3 to 35~45℃, add it to the emulsifier for emulsification, add the balance of deioni...

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Abstract

The invention discloses an antibody preparation for preventing and treating bovine viral diarrhea. Every 100 g of the preparation is prepared from the following components by weight: 0.01-10.0 g of bovine viral diarrhea antibodies, 15.0-25.0 g of lecithin, 5.0-30.0 g of polyethylene glycol 800, 0.01-2.0 g of beta-sitosterol, 1.0-5.0 g of corilagin, 10.0-20.0 g of tween-20 and the balance of deionized water. Meanwhile, the invention further discloses a preparation method, process operability is high, and production conversion is facilitated. The antibody preparation can prevent the antibodies from being degraded in the rumen after being orally taken, can be fused with intestinal mucosal cells after entering intestinal tracts, releases the antibody, neutralizes viruses on the surface of mucosas and has the characteristic of high bioavailability, and the clinical curative effect is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to an antibody preparation for preventing and treating bovine viral diarrhea and a preparation method thereof. Background technique [0002] Bovine viral diarrhea is caused by bovine viral diarrhea virus infection. The pathogen belongs to the genus Pestivirus in the Flaviviridae family. Cattle of all ages can be infected, and young cattle are most susceptible. The pathological features of the infected cattle showed erosion, inflammation and shedding of intestinal mucosa, watery feces, foul smell, a lot of mucus and air bubbles. Sick cows have elevated body temperature, abdominal pain, decreased feed intake, and indigestion of feed, which seriously affect growth and development, and some cows may even die, and pregnant cows may suffer from miscarriage. Once the cattle farm is infected with this disease, if there is no effective control plan, it will eventual...

Claims

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Application Information

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IPC IPC(8): A61K39/42A61K9/10A61K47/10A61K47/24A61K47/26A61P1/12A61P31/14A61K31/575A61K31/7028
CPCA61K39/42A61K31/575A61K31/7028A61K9/10A61K47/24A61K47/10A61K47/26A61P1/12A61P31/14A61K2039/505A61K2300/00Y02A50/30
Inventor 马超锋杨高杰侯站民余洪涛叶丛华周爱军周应海
Owner 信阳市动物疫病预防控制中心
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